Lipids in the Bone Marrow: An Evolving Perspective.
Document Type
Article
Publication Date
2-4-2020
Institution/Department
Center for Molecular Medicine, Maine Medical Center Research Institute
Journal Title
Cell Metab
MeSH Headings
Bone Marrow, Lipids
Abstract
Because of heavy energy demands to maintain bone homeostasis, the skeletal system is closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose, amino acids, and fatty acids are the chief fuel sources for bone resident cells during its remodeling. Lipids, which can be mobilized from intracellular depots in the bone marrow, can be a potent source of fatty acids. Thus, while it has been suggested that adipocytes in the bone marrow act as "filler" and are detrimental to skeletal homeostasis, we propose that marrow lipids are, in fact, essential for proper bone functioning. As such, we examine the prevailing evidence regarding the storage, use, and export of lipids within the skeletal niche, including from both in vitro and in vivo model systems. We also highlight the numerous challenges that remain to fully appreciate the relationship of lipid turnover to skeletal homeostasis.
ISSN
1932-7420
First Page
219
Last Page
231
Recommended Citation
Rendina-Ruedy, Elizabeth and Rosen, Clifford J, "Lipids in the Bone Marrow: An Evolving Perspective." (2020). Maine Medical Center. 1763.
https://knowledgeconnection.mainehealth.org/mmc/1763
