Lipids in the Bone Marrow: An Evolving Perspective.

Document Type

Article

Publication Date

2-4-2020

Institution/Department

Center for Molecular Medicine; Maine Medical Center Research Institute

Journal Title

Cell Metab

MeSH Headings

Bone Marrow, Lipids

Abstract

Because of heavy energy demands to maintain bone homeostasis, the skeletal system is closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose, amino acids, and fatty acids are the chief fuel sources for bone resident cells during its remodeling. Lipids, which can be mobilized from intracellular depots in the bone marrow, can be a potent source of fatty acids. Thus, while it has been suggested that adipocytes in the bone marrow act as "filler" and are detrimental to skeletal homeostasis, we propose that marrow lipids are, in fact, essential for proper bone functioning. As such, we examine the prevailing evidence regarding the storage, use, and export of lipids within the skeletal niche, including from both in vitro and in vivo model systems. We also highlight the numerous challenges that remain to fully appreciate the relationship of lipid turnover to skeletal homeostasis.

ISSN

1932-7420

First Page

219

Last Page

231

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