The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage.

Document Type

Article

Publication Date

9-3-2019

Institution/Department

Center for Molecular Medicine; Maine Medical Center Research Institute

Journal Title

Proceedings of the National Academy of Sciences of the United States of America

MeSH Headings

Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Animals, Apoptosis, Bone and Bones, DNA Damage, Dietary Fats, HSP70 Heat-Shock Proteins, Hydrogen Peroxide, Mice, Mice, Knockout, NF-kappa B, Osteoblasts, Signal Transduction, Stress, Physiological, Ultraviolet Rays

Abstract

The fat mass and obesity-associated gene (

ISSN

1091-6490

First Page

17980

Last Page

17989

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