Real-time H2 O2 measurements in bone marrow mesenchymal stem cells (MSCs) show increased antioxidant capacity in cells from osteoporotic women.

Document Type

Article

Publication Date

3-2017

Institution/Department

MMCRI

Journal Title

Journal of cellular biochemistry

MeSH Headings

Aged, Antioxidants, Bone Marrow Cells, Cells, Cultured, Female, Humans, Hydrogen Peroxide, Mesenchymal Stromal Cells, Middle Aged, Osteoporosis, Postmenopausal, Oxidoreductases, Signal Transduction

Abstract

Oxidative stress (OS) derived from an increase in intracellular reactive oxygen species (ROS) is a major determinant of aging and lifespan. It has also been associated with several age-related disorders, like postmenopausal osteoporosis of Mesenchymal stem cells (MSCs). MSCs are the common precursors for osteoblasts and adipocytes; appropriate commitment and differentiation of MSCs into a specific phenotype is modulated, among other factors, by ROS balance. MSCs have shown more resistance to ROS than differentiated cells, and their redox status depends on complex and abundant anti-oxidant mechanisms. The purpose of this work was to analyze in real time, H

ISSN

1097-4644

First Page

585

Last Page

593

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