Real-time H2 O2 measurements in bone marrow mesenchymal stem cells (MSCs) show increased antioxidant capacity in cells from osteoporotic women.
Journal of cellular biochemistry
Aged, Antioxidants, Bone Marrow Cells, Cells, Cultured, Female, Humans, Hydrogen Peroxide, Mesenchymal Stromal Cells, Middle Aged, Osteoporosis, Postmenopausal, Oxidoreductases, Signal Transduction
Oxidative stress (OS) derived from an increase in intracellular reactive oxygen species (ROS) is a major determinant of aging and lifespan. It has also been associated with several age-related disorders, like postmenopausal osteoporosis of Mesenchymal stem cells (MSCs). MSCs are the common precursors for osteoblasts and adipocytes; appropriate commitment and differentiation of MSCs into a specific phenotype is modulated, among other factors, by ROS balance. MSCs have shown more resistance to ROS than differentiated cells, and their redox status depends on complex and abundant anti-oxidant mechanisms. The purpose of this work was to analyze in real time, H
Román, Flavia; Urra, Carla; Porras, Omar; Pino, Ana María; Rosen, Clifford J.; and Rodríguez, Juan Pablo, "Real-time H2 O2 measurements in bone marrow mesenchymal stem cells (MSCs) show increased antioxidant capacity in cells from osteoporotic women." (2017). Maine Medical Center. 197.