First-in-class humanized FSH blocking antibody targets bone and fat.

Document Type

Article

Publication Date

10-30-2020

Institution/Department

Center for Clinical and Translational Research; Maine Medical Center Research Institute

Journal Title

Proceedings of the National Academy of Sciences of the United States of America

MeSH Headings

Antibodies, Blocking, Immunoglobulin Isotypes, Bone and Bones, Follicle Stimulating Hormone

Abstract

Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH agent a potential therapeutic for three global epidemics: obesity, osteoporosis, and hypercholesterolemia. Here, we report the generation, structure, and function of a first-in-class, fully humanized, epitope-specific FSH blocking antibody with a

ISSN

1091-6490

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