First-in-class humanized FSH blocking antibody targets bone and fat.
Document Type
Article
Publication Date
10-30-2020
Institution/Department
Center for Clinical and Translational Research; Maine Medical Center Research Institute
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
MeSH Headings
Antibodies, Blocking, Immunoglobulin Isotypes, Bone and Bones, Follicle Stimulating Hormone
Abstract
Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH agent a potential therapeutic for three global epidemics: obesity, osteoporosis, and hypercholesterolemia. Here, we report the generation, structure, and function of a first-in-class, fully humanized, epitope-specific FSH blocking antibody with a
ISSN
1091-6490
Recommended Citation
Gera, Sakshi; Sant, Damini; Haider, Shozeb; Korkmaz, Funda; Kuo, Tan-Chun; Mathew, Mehr; Perez-Pena, Helena; Xie, Honglin; Chen, Hao; Batista, Rogerio; Ma, Kejun; Cheng, Zhen; Hadelia, Elina; Robinson, Cemre; Macdonald, Anne; Miyashita, Sari; Williams, Anthony; Jebian, Gregory; Miyashita, Hirotaka; Gumerova, Anisa; Ievleva, Kseniia; Smith, Pinar; He, Jiahuan; Ryu, Vitaly; DeMambro, Victoria; Quinn, Matthew A; Meseck, Marcia; Kim, Se-Min; Kumar, T Rajendra; Iqbal, Jameel; New, Maria I; Lizneva, Daria; Rosen, Clifford J; Hsueh, Aaron J; Yuen, Tony; and Zaidi, Mone, "First-in-class humanized FSH blocking antibody targets bone and fat." (2020). MaineHealth Maine Medical Center. 1995.
https://knowledgeconnection.mainehealth.org/mmc/1995