Hyponatremia increases mortality in pediatric patients listed for liver transplantation.

Document Type

Article

Publication Date

2-1-2010

Institution/Department

Pediatrics

Journal Title

Pediatric transplantation

MeSH Headings

Child, Child, Preschool, Female, Follow-Up Studies, Humans, Hyponatremia, Infant, Liver Failure, Liver Transplantation, Male, Preoperative Period, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, United States, Waiting Lists

Abstract

To evaluate hyponatremia as an independent predictor of mortality in pediatric patients with end-stage liver disease listed for transplantation. We performed a single-center retrospective study of children listed for liver transplantation. We defined hyponatremia as a serum sodium concentration/L that persisted for at least seven days. The primary outcome was death on the waiting list. Ninety-four patients were eligible for the study. The prevalence of hyponatremia was 26%. Kaplan-Meier survival analysis demonstrated that patients with hyponatremia had decreased pretransplant survival compared with patients who maintained a serum sodium >130 mEq/L (p < 0.001). Univariable association analyses demonstrated death on the waiting list was also associated with higher median PELD scores at listing (p = 0.01), non-white race (p = 0.02), and age

ISSN

1399-3046

First Page

115

Last Page

120

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