Hyponatremia increases mortality in pediatric patients listed for liver transplantation.
Child, Child, Preschool, Female, Follow-Up Studies, Humans, Hyponatremia, Infant, Liver Failure, Liver Transplantation, Male, Preoperative Period, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, United States, Waiting Lists
To evaluate hyponatremia as an independent predictor of mortality in pediatric patients with end-stage liver disease listed for transplantation. We performed a single-center retrospective study of children listed for liver transplantation. We defined hyponatremia as a serum sodium concentration/L that persisted for at least seven days. The primary outcome was death on the waiting list. Ninety-four patients were eligible for the study. The prevalence of hyponatremia was 26%. Kaplan-Meier survival analysis demonstrated that patients with hyponatremia had decreased pretransplant survival compared with patients who maintained a serum sodium >130 mEq/L (p < 0.001). Univariable association analyses demonstrated death on the waiting list was also associated with higher median PELD scores at listing (p = 0.01), non-white race (p = 0.02), and age
Carey, Rebecca G; Bucuvalas, John C; Balistreri, William F; Nick, Todd G; Ryckman, Frederick R; and Yazigi, Nada, "Hyponatremia increases mortality in pediatric patients listed for liver transplantation." (2010). Maine Medical Center. 2157.