A Case of Cefepime-Induced Immune Thrombocytopenia

Document Type

Article

Publication Date

4-1-2022

Journal Title

Journal of clinical pharmacy and therapeutics

MeSH Headings

Adult; Blood Platelets; Cefepime (adverse effects); Humans; Male; Purpura, Thrombocytopenic, Idiopathic (chemically induced, diagnosis); Thrombocytopenia (chemically induced)

Abstract

WHAT IS KNOWN AND OBJECTIVE: Drug-induced immune thrombocytopenia (DITP) is a rare adverse event. It is often diagnosed using clinical risk criteria, but this can create diagnostic uncertainty. CASE DESCRIPTION: A 35-year-old man with disseminated Serratia marcescens infection developed severe thrombocytopenia. A drug-dependent platelet-reactive antibody test demonstrated cefepime-dependent platelet-reactive antibodies which confirmed the diagnosis of DITP. WHAT IS NEW AND CONCLUSION: We describe the first case of cefepime-induced DITP confirmed by a drug-dependent platelet-reactive antibody test. To our knowledge, this is the first proven example of DITP in a fourth-generation cephalosporin.

First Page

556

Last Page

558

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