Using controlled substance receipt patterns to predict prescription overdose death.
BACKGROUND: This study evaluates complete state data from controlled substance prescribing trends in the prescription monitoring program (PMP) database and their association with the risk of prescription drug overdose death.
SUMMARY: Maine PMP records of individuals who died of prescription overdose deaths between 2006 and 2010 were selected (n = 690). For each subject, an age, gender, and residence matched cohort of PMP users in a 50: 1 ratio was identified (n = 34,500). Key Messages: Prescription opioids contributed to 480 of 690 prescription deaths, many co-ingestions were noted, and OR for overdose death increased with milligram of morphine equivalent (MME)/day >100. The majority who were prescribed MME >100 per day received a prescription within 90 days of overdose matching the toxicology cause of death.
CONCLUSIONS: Medication profiles available through state PMP can identify dosing of prescriptions associated with drug overdose death.
Holt, Christina T.; McCall, Kenneth L.; Cattabriga, Gary; Tu, Chunhao; Smalley, Elenna K.; and Nichols, Stephanie D., "Using controlled substance receipt patterns to predict prescription overdose death." (2018). Maine Medical Center. 262.