Adverse Outcomes of Pregnancy in Women Exposed to Diethylstilbestrol In Utero

Document Type

Article

Publication Date

1-1988

Institution/Department

Obstetrics and Gynecology

Journal Title

The Journal of Reproductive Medicine

MeSH Headings

Demography; Diethylstilbestrol (adverse effects); Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications (etiology); Pregnancy Outcome; Random Allocation; Statistics as Topic

Abstract

We analyzed data collected by interview and medical record review for 200 women exposed to diethylstilbestrol (DES) and 12,240 unexposed women to evaluate the relation between maternal DES exposure and outcomes of pregnancy. Low birth weight, short gestation, bleeding in the first trimester, toxemia, breech presentation and premature rupture of the membranes occurred more often among the exposed women. These relationships remained statistically significant after the use of linear regression and logistic regression analyses to control for multiple confounding factors. Both exposed women and their physicians should be aware of the possible relationship between maternal exposure to DES and late adverse outcomes of pregnancy. Close medical supervision of these women throughout pregnancy and delivery is recommended.

ISSN

0024-7758

First Page

3

Last Page

7

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