Potential Mechanisms of Gut-Derived Extracellular Vesicle Participation in Glucose and Lipid Homeostasis

Authors

Tiange Feng, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
Weizhen Zhang, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
Ziru Li, MaineHealth Institute for Research, MaineHealth, Scarborough, ME 04074, USA.Follow

Document Type

Article

Publication Date

10-28-2022

Institution/Department

MaineHealth Institute for Research

Journal Title

Genes

MeSH Headings

Glucose (metabolism); Homeostasis; Gastrointestinal Microbiome; Extracellular Vesicles (genetics, metabolism); Lipids

Abstract

The intestine participates in the regulation of glucose and lipid metabolism in multiple facets. It is the major site of nutrient digestion and absorption, provides the interface as well as docking locus for gut microbiota, and harbors hormone-producing cells scattered throughout the gut epithelium. Intestinal extracellular vesicles are known to influence the local immune response, whereas their roles in glucose and lipid homeostasis have barely been explored. Hence, this current review summarizes the latest knowledge of cargo substances detected in intestinal extracellular vesicles, and connects these molecules with the fine-tuning regulation of glucose and lipid metabolism in liver, muscle, pancreas, and adipose tissue.

Recommended Citation

Feng T, Zhang W, Li Z. Potential Mechanisms of Gut-Derived Extracellular Vesicle Participation in Glucose and Lipid Homeostasis. Genes (Basel). 2022;13(11):1964. Published 2022 Oct 28. doi:10.3390/genes13111964