Novel biological therapies targeting heart failure: myocardial rejuvenation.

Authors

Amanda J. Favreau-Lessard, Maine Medical Center
Sergey Ryzhov, Maine Medical Center
Douglas B. Sawyer, Maine Medical CenterFollow

Document Type

Article

Publication Date

7-2016

Institution/Department

Molecular Medicine; MMCRI

Journal Title

Heart failure clinics

MeSH Headings

Biological Therapy, Genetic Therapy, Heart Failure, Humans, Rejuvenation, Signal Transduction, Stem Cell Transplantation, Translational Medical Research

Abstract

Recovery of ventricular function occurs in a subset of patients with advanced heart failure treated with medical and/or mechanical therapy. Finding strategies that induce ventricular recovery through induction of repair, regeneration, or "rejuvenation" is a long-sought goal of research programs. Cell-based strategies, use of recombinant growth and survival factors, and gene delivery are under investigation. In this brief article we highlight a few of the biological approaches in development to treat heart failure.

ISSN

1551-7136

First Page

461

Last Page

471

Recommended Citation

Favreau-Lessard, Amanda J.; Ryzhov, Sergey; and Sawyer, Douglas B., "Novel biological therapies targeting heart failure: myocardial rejuvenation." (2016). MaineHealth Maine Medical Center. 297.
https://knowledgeconnection.mainehealth.org/mmc/297