Title

Bone morphogenetic protein signaling in nephron progenitor cells.

Document Type

Article

Publication Date

4-2014

Institution/Department

MMCRI, Molecular Medicine

Journal Title

Pediatric nephrology (Berlin, Germany)

MeSH Headings

Animals, Bone Morphogenetic Proteins, Humans, Nephrons, Organogenesis, Signal Transduction, Stem Cells

ISSN

1432-198X

Abstract

Bone morphogenetic protein (BMP) signaling plays an essential role in many aspects of kidney development, and is a major determinant of outcome in kidney injury. BMP treatment is also an essential component of protocols for differentiation of nephron progenitors from pluripotent stem cells. This review discusses the role of BMP signaling to nephron progenitor cells in each of these contexts.

First Page

531

Last Page

536

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