Carotid artery velocity time integral and corrected flow time measured by a wearable Doppler ultrasound detect stroke volume rise from simulated hemorrhage to transfusion

Authors

Jon-Émile S. Kenny, Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2, Canada. jon-emile@heart-lung.org.
Igor Barjaktarevic, Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
David C. Mackenzie, Department of Emergency Medicine, Maine Medical Center, Portland, ME, USA.
Mai Elfarnawany, Flosonics Medical, 325 Front Street, Toronto, ON, M5V 2Y1, Canada.
Zhen Yang, Flosonics Medical, 325 Front Street, Toronto, ON, M5V 2Y1, Canada.
Andrew M. Eibl, Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2, Canada.
Joseph K. Eibl, Health Sciences North Research Institute, 56 Walford Rd, Sudbury, ON, P3E 2H2, Canada.
Chul-Ho Kim, Human Integrative and Environmental Physiology Laboratory, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Bruce D. Johnson, Human Integrative and Environmental Physiology Laboratory, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Document Type

Article

Publication Date

1-10-2022

Journal Title

BMC research notes

MeSH Headings

Blood Flow Velocity; Carotid Arteries (diagnostic imaging); Carotid Artery, Common; Hemorrhage; Humans; Stroke Volume; Ultrasonography, Doppler; Wearable Electronic Devices

Abstract

OBJECTIVE: Doppler ultrasonography of the common carotid artery is used to infer stroke volume change and a wearable Doppler ultrasound has been designed to improve this workflow. Previously, in a human model of hemorrhage and resuscitation comprising approximately 50,000 cardiac cycles, we found a strong, linear correlation between changing stroke volume, and measures from the carotid Doppler signal, however, optimal Doppler thresholds for detecting a 10% stroke volume change were not reported. In this Research Note, we present these thresholds, their sensitivities, specificities and areas under their receiver operator curves (AUROC). RESULTS: Augmentation of carotid artery maximum velocity time integral and corrected flowtime by 18% and 4%, respectively, accurately captured 10% stroke volume rise. The sensitivity and specificity for these thresholds were identical at 89% and 100%. These data are similar to previous investigations in healthy volunteers monitored by the wearable ultrasound.

First Page

7

Recommended Citation

Kenny JS, Barjaktarevic I, Mackenzie DC, et al. Carotid artery velocity time integral and corrected flow time measured by a wearable Doppler ultrasound detect stroke volume rise from simulated hemorrhage to transfusion. BMC Res Notes. 2022;15(1):7. Published 2022 Jan 10. doi:10.1186/s13104-021-05896-y