Thyroid Hormone Metabolism: A Historical Perspective

Authors

Valerie Anne Galton, Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Arturo Hernandez, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA.Follow

Document Type

Article

Publication Date

1-2023

Institution/Department

Center for Molecular Medicine; MaineHealth Institute for Research

Journal Title

Thyroid : official journal of the American Thyroid Association

MeSH Headings

Humans; Triiodothyronine (metabolism); Thyroxine (metabolism); Thyroid Hormones (metabolism); Thyroid Gland (metabolism); Iodine (metabolism)

Abstract

In this article, starting with the recognition that iodine is essential for normal thyroid function and is a component of thyroid hormone (TH) molecules, we discuss the many seminal observations and discoveries that have led to identification of various pathways of TH metabolism and their potential roles in TH economy and action. We then recount evidence that TH metabolism participates in maintaining the appropriate content of active hormone in a TH-responsive tissue or cell. Thus, metabolism of the TH is not merely a means by which it is degraded and eliminated from the body, but an essential component of an intricate system by which the thyroid exerts its multiple regulatory effects on almost all organs and tissues. The article ends with a summary of the current concepts and some outstanding questions that are awaiting answers.

First Page

24

Last Page

31

Recommended Citation

Galton VA, Hernandez A. Thyroid Hormone Metabolism: A Historical Perspective. Thyroid. 2023;33(1):24-31. doi:10.1089/thy.2022.0161