Acute management of spontaneous intracerebral hemorrhage (ICH) in the emergency department

Document Type

Article

Publication Date

1-30-2026

Institution/Department

Center for Interdisciplinary Population and Health Research

Journal Title

International journal of emergency medicine

Abstract

BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is a catastrophic form of stroke affecting more than 3.3 million individuals worldwide each year and accounting for approximately 10-20% of all strokes globally. Although less common than acute ischemic stroke, ICH carries a disproportionate burden of morbidity and mortality, with 30-day case fatality rates approaching 40-50%. Therapeutic advances for ICH have progressed more slowly than for ischemic stroke, and management remains largely supportive. Patients frequently present to the emergency department (ED) in critical condition, making early recognition and rapid, guideline-concordant intervention essential to improving outcomes. REVIEW: This narrative review summarizes the most recent American Heart Association/American Stroke Association (AHA/ASA) guidelines for the acute management of spontaneous ICH, with emphasis on practical ED application. Hypertension remains the most important modifiable risk factor, particularly in younger patients, while cerebral amyloid angiopathy predominates in older adults. Additional risk factors include anticoagulant and antiplatelet therapy, alcohol and illicit drug use, smoking, advanced age, and genetic predisposition. Primary brain injury results from hematoma mass effect and elevated intracranial pressure, followed by secondary injury driven by edema, inflammation, and oxidative stress. Because hematoma expansion commonly occurs within the first hours after symptom onset and strongly predicts mortality, early ED management prioritizes rapid neuroimaging, controlled blood pressure reduction, timely anticoagulation reversal, seizure management, metabolic and temperature control, and prompt neurosurgical consultation when indicated. Emerging evidence supports bundled, time-sensitive care pathways to reduce delays and optimize outcomes. CONCLUSION: Optimal ICH outcomes depend on rapid, structured, guideline-concordant ED care focused on limiting hematoma expansion and secondary injury. Standardized workflows and bundled interventions represent effective strategies for improving survival and functional outcomes while avoiding premature prognostication in the acute phase.

ISSN

1865-1372

First Page

35

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