Omics characteristics and epigenetic modifications of adipose-derived stem cells.
Document Type
Article
Publication Date
11-2025
Institution/Department
Center for Molecular Medicine
Journal Title
The Journal of biological chemistry
MeSH Headings
Humans, Epigenesis, Genetic, Adipose Tissue, Animals, Stem Cells, Cell Differentiation, Proteomics, Adipocytes
Abstract
Adipose-derived stem cells (ADSCs) possess multipotency to differentiate into various lineages, including adipocytes, osteoblasts, neurons, and smooth muscle cells, thereby demonstrating significant potential in tissue regeneration. Recent advances in omics technologies have enhanced our understanding of ADSC molecular profiles by transcriptomic, proteomic and lipidomic analysis. Additionally, epigenetic modifications, which mediate heritable changes in gene expression without altering the DNA sequence, play a pivotal role during the multiple lineage differentiation of ADSC. This review presents a summary of recent findings on ADSC omics and epigenetics, offering an updated perspective on their distinct attributes.
ISSN
1083-351X
First Page
110758
Last Page
110758
Recommended Citation
Feng, Tiange; Rosen, Clifford J.; and Li, Ziru, "Omics characteristics and epigenetic modifications of adipose-derived stem cells." (2025). MaineHealth Maine Medical Center. 4419.
https://knowledgeconnection.mainehealth.org/mmc/4419
