Increased spontaneous physical activity in female MEST-deficient mice protects against diet-induced obesity.

Authors

• Rea Victoria P Anunciado-Koza, MaineHealth
• M Elena Martinez, MaineHealth
• Victoria DeMambro, MaineHealth
• Arturo Hernandez, MaineHealth
• Robert A Koza, MaineHealth

Document Type

Article

Publication Date

10-2025

Institution/Department

Center for Molecular Medicine

Journal Title

Front Endocrinol (Lausanne)

MeSH Headings

Animals, Female, Mice, Obesity, Male, Diet, Western, Mice, Inbred C57BL, Mice, Knockout, Physical Conditioning, Animal, Iodide Peroxidase, Body Composition, Body Weight

Abstract

INTRODUCTION: Mesoderm-specific transcript (

METHODS: Eight-week-old female and male wild-type and

RESULTS:

CONCLUSION: Mechanistically, our results suggest that MEST directly or indirectly regulates thyroid hormone-responsive genes in the hypothalamus, thereby modulating the neurobiological control of nonexercise activity thermogenesis in Western diet-fed female mice.

ISSN

1664-2392

First Page

1680158

Last Page

1680158

Recommended Citation

Anunciado-Koza, Rea Victoria P; Martinez, M Elena; DeMambro, Victoria; Hernandez, Arturo; and Koza, Robert A, "Increased spontaneous physical activity in female MEST-deficient mice protects against diet-induced obesity." (2025). MaineHealth Maine Medical Center. 4421.
https://knowledgeconnection.mainehealth.org/mmc/4421