Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice.
Document Type
Article
Publication Date
4-1-2025
Institution/Department
Center for Molecular Medicine
Journal Title
American journal of physiology. Endocrinology and metabolism
MeSH Headings
Animals, Male, Mice, Obesity, Gastrectomy, Glucagon-Like Peptides, Energy Metabolism, Bone Density, Heart, Mice, Inbred C57BL, Weight Loss, Bone and Bones, Mice, Obese, Glucagon-Like Peptide 1, Semaglutide
Abstract
Obesity is a global health challenge associated with significant metabolic and cardiovascular risks. Bariatric surgery and glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective interventions for weight loss and metabolic improvement, yet their comparative effects on systemic metabolism-particularly energy metabolism, bone health, and heart function-remain unclear. In this study, obese male mice underwent vertical sleeve gastrectomy (VSG), 6 wk of GLP-1RA (semaglutide) treatment, or sham procedure with saline injection as controls. Dynamic changes in body weight, food intake, fat mass, lean mass, and bone mineral density were monitored. Energy metabolism was assessed using indirect calorimetry. Bone parameters and heart function were evaluated by microcomputed tomography or echocardiography, respectively. Compared with obese controls, VSG and semaglutide treatment comparably reduced body weight and improved glucose metabolism. However, VSG decreased energy expenditure, whereas both treatments similarly promoted lipid utilization. Semaglutide treatment increased ambulatory activity during nighttime. VSG led to significant bone loss, although 6 wk of semaglutide treatment had no significant effects on the skeleton. Cardiovascular outcomes also differed: VSG increased stroke volume without altering heart mass, whereas semaglutide reduced heart mass and transiently elevated heart rate. These findings underscore the importance of carefully weighing the benefits and potential risks of different weight loss treatments when addressing obesity and its systemic complications.
ISSN
1522-1555
First Page
555
Last Page
555
Recommended Citation
Picoli, Caroline de Carvalho; Tsibulnikov, Sergey; Ho, Mavy; DeMambro, Victoria; Feng, Tiange; Eltahir, May; Le, Phuong T; Chlebek, Carolyn; Rosen, Clifford J; Ryzhov, Sergey; and Li, Ziru, "Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice." (2025). MaineHealth Maine Medical Center. 4439.
https://knowledgeconnection.mainehealth.org/mmc/4439
