Clinical characterization of membrane oxygenator exhaust capnometry during venovenous extracorporeal membrane oxygenation

Authors

• John W. Stokes, Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
• Whitney D. Gannon, Department of Pulmonary, Allergy, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
• Elizabeth Simonds, Vanderbilt University School of Medicine, Nashville, TN, USA.
• Ioannis A. Ziogas, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, USA.
• W Kelly Wu, Transplant Center, Cleveland Clinic, Cleveland, OH, USA.
• Yatrik J. Patel, Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
• Sean A. Francois, MaineHealth

Document Type

Article

Publication Date

5-7-2026

Institution/Department

Surgery

Journal Title

Scientific reports

Abstract

Capnometry is a cost-efficient method of monitoring carbon dioxide (CO) in healthcare settings, especially during mechanical ventilation and cardiopulmonary bypass. However, the utility of capnometers for studying CO elimination in a longer-duration, clinical extracorporeal membrane oxygenation (ECMO) has been poorly characterized. This report presents data from 10 venovenous ECMO patients at Vanderbilt University Medical Center between April and June 2021. Exhaust CO was intermittently measured from a membrane oxygenator's gas outlet, and arterial blood samples were simultaneously drawn from the patient. Clinical variables including ECMO and ventilator management, patient demographics, and outcomes were recorded. Exhaust CO and other study variables were recorded at 233 discrete time points from the 10 patients. The median duration of ECMO support was 9 days. Sweep gas flow rate demonstrated a strong, negative correlation with exhaust CO concentration, from both univariate and multivariate regression analyses (adjusted β = - 5.556 for sweep <  4 L/min, p <  0.001). Blood flow, oxygenator duration of use, and arterial CO demonstrated weaker relationships with exhaust CO (adjusted β = 2.341, - 0.258, 0.175, respectively), which agrees with the clinical understanding about CO management during ECMO. This descriptive study provides foundation for future research to precisely define the clinical role of ECMO exhaust capnometry in the management of the sweep gas flow and the overall therapy.

Recommended Citation

Stokes, John W.; Gannon, Whitney D.; Simonds, Elizabeth; Ziogas, Ioannis A.; Wu, W Kelly; Patel, Yatrik J.; and Francois, Sean A., "Clinical characterization of membrane oxygenator exhaust capnometry during venovenous extracorporeal membrane oxygenation" (2026). MaineHealth Maine Medical Center. 4504.
https://knowledgeconnection.mainehealth.org/mmc/4504