Implications of GLP-1 receptor agonists for the fertility of women with polyendocrine metabolic ovarian syndrome

Authors

• Pawel Kordowitzki
• Anju E. Joham
• Clifford J. Rosen, Tufts University School of Medicine, Boston, MA, USA; Maine Medical Center Institute for Research, Scarborough, ME, USA.

Document Type

Article

Publication Date

9-8-2026

Institution/Department

Center for Molecular Medicine

Journal Title

Cell metabolism

Abstract

Women with polyendocrine metabolic ovarian syndrome (PMOS) represent a particularly challenging patient population, characterized by the convergence of reproductive dysfunction, obesity, insulin resistance, and chronic inflammation. The emergence of glucagon-like peptide-1 receptor agonists (GLP-1RAs) offers a transformative therapeutic opportunity, addressing the complex endocrine and reproductive disturbances that underpin this disorder.

Recommended Citation

Kordowitzki, Pawel; Joham, Anju E.; and Rosen, Clifford J., "Implications of GLP-1 receptor agonists for the fertility of women with polyendocrine metabolic ovarian syndrome" (2026). MaineHealth Maine Medical Center. 4677.
https://knowledgeconnection.mainehealth.org/mmc/4677