Emergence of inactivating NOTCH1 mutations in an IDH-mutant astrocytoma with clinical resistance to vorasidenib treatment

Authors

• Tomoyuki Nakano, Translational Neuro-Oncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
• Nicholas A. Jessop, Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
• Charlotte I. Wang, Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
• Maria Martinez-Lage, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
• Itay Tirosh, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 761001, Israel.
• Mario L. Suva, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
• Hiroaki Wakimoto, Translational Neuro-Oncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
• Daniel P. Cahill, Translational Neuro-Oncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
• Christine Lu-Emerson, Department of Neurology and Division of Oncology, MaineHealth, Scarborough, ME 04074, USA.Follow

Document Type

Article

Publication Date

10-15-2026

Institution/Department

Neurology; Oncology

Journal Title

Neuro-oncology

Recommended Citation

Nakano, Tomoyuki; Jessop, Nicholas A.; Wang, Charlotte I.; Martinez-Lage, Maria; Tirosh, Itay; Suva, Mario L.; Wakimoto, Hiroaki; Cahill, Daniel P.; and Lu-Emerson, Christine, "Emergence of inactivating NOTCH1 mutations in an IDH-mutant astrocytoma with clinical resistance to vorasidenib treatment" (2026). MaineHealth Maine Medical Center. 4704.
https://knowledgeconnection.mainehealth.org/mmc/4704