Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy.

Authors

Timothy P Fitzgibbons
Yvonne J K Edwards
Peter Shaw
Aline Iskandar, Maine Medical Center
Mohamed Ahmed
Josiah Bote
Tejen Shah
Sumita Sinha
Robert E Gerszten
John F Keaney
Michael R Zile
Gerard P Aurigemma

Document Type

Article

Publication Date

1-1-2017

Institution/Department

Cardiology

Journal Title

Frontiers in cardiovascular medicine.

Abstract

Stress cardiomyopathy (SCM) is a unique cardiac disorder that more often occurs in women. SCM presents in a similar fashion as acute myocardial infarction (AMI), with chest pain, ECG changes, and congestive heart failure. The primary distinguishing feature is the absence of thrombotic coronary occlusion in SCM. How this reduction in cardiac function occurs in the absence of coronary occlusion remains unknown. Therefore, we tested the hypothesis that a targeted proteomic comparison of patients with acute SCM and AMI might identify relevant mechanistic differences. Blood was drawn in normal controls (

ISSN

2297-055X

First Page

49

Last Page

49

Recommended Citation

Fitzgibbons, Timothy P; Edwards, Yvonne J K; Shaw, Peter; Iskandar, Aline; Ahmed, Mohamed; Bote, Josiah; Shah, Tejen; Sinha, Sumita; Gerszten, Robert E; Keaney, John F; Zile, Michael R; and Aurigemma, Gerard P, "Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy." (2017). MaineHealth Maine Medical Center. 526.
https://knowledgeconnection.mainehealth.org/mmc/526