Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy.
Frontiers in cardiovascular medicine.
Stress cardiomyopathy (SCM) is a unique cardiac disorder that more often occurs in women. SCM presents in a similar fashion as acute myocardial infarction (AMI), with chest pain, ECG changes, and congestive heart failure. The primary distinguishing feature is the absence of thrombotic coronary occlusion in SCM. How this reduction in cardiac function occurs in the absence of coronary occlusion remains unknown. Therefore, we tested the hypothesis that a targeted proteomic comparison of patients with acute SCM and AMI might identify relevant mechanistic differences. Blood was drawn in normal controls (
Fitzgibbons, Timothy P; Edwards, Yvonne J K; Shaw, Peter; Iskandar, Aline; Ahmed, Mohamed; Bote, Josiah; Shah, Tejen; Sinha, Sumita; Gerszten, Robert E; Keaney, John F; Zile, Michael R; and Aurigemma, Gerard P, "Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy." (2017). Maine Medical Center. 526.