Repurposing valproate, enteral clonidine, and phenobarbital for comfort in adult ICU patients: a literature review with practical considerations.

Document Type

Article

Publication Date

10-1-2017

Institution/Department

Pharmacy; Critical Care

Journal Title

Pharmacotherapy

MeSH Headings

Administration, Oral, Administration, Sublingual, Adult, Clonidine, Critical Illness, Drug Repositioning, Humans, Hypnotics and Sedatives, Intensive Care Units, Patient Comfort, Phenobarbital, Valproic Acid

Abstract

Provision of adequate sedation is a fundamental part of caring for critically ill patients. Propofol, dexmedetomidine, and benzodiazepines are the most commonly administered sedative medications for adult patients in the intensive care unit (ICU). These agents are limited by adverse effects, need for a monitored environment for safe administration, and lack of universal effectiveness. Increased interest has recently been expressed about repurposing older pharmacologic agents for patient comfort in the ICU. Valproate, enteral clonidine, and phenobarbital are three agents with increasing evidence supporting their use. Potential benefits associated with their utilization are cost minimization and safe administration after transition out of the ICU. This literature review describes the historical context, pharmacologic characteristics, supportive data, and practical considerations associated with the administration of these agents for comfort in critically ill adult patients.

ISSN

1875-9114

First Page

1309

Last Page

1321

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