Survival following Ommaya reservoir placement for neoplastic meningitis.

Document Type

Article

Publication Date

9-1-2015

Institution/Department

Neurology, Surgery, Nursing

Journal Title

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.

MeSH Headings

Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Drug Delivery Systems, Female, Humans, Infusions, Intraventricular, Kaplan-Meier Estimate, Male, Meningeal Carcinomatosis, Middle Aged, Prognosis, Proportional Hazards Models, Prostheses and Implants, Retrospective Studies

Abstract

The objective of this study was to evaluate the outcomes of patients with neoplastic meningitis (NM) following Ommaya reservoir placement in order to determine whether any patient factors are associated with longer survival. NM is a devastating late manifestation of cancer, and given its dismal prognosis, identifying appropriate patients for Ommaya reservoir placement is difficult. The authors performed a retrospective review of 80 patients who underwent Ommaya reservoir placement at three medical centers from September 2001 through September 2012. The primary outcome was death. Differences in survival were assessed with Kaplan-Meier survival analyses. The Cox proportional hazards and logistic regression modeling were performed to identify factors associated with survival. The primary diagnoses were solid organ, hematologic, and primary central nervous system tumors in 53.8%, 41.3%, and 5%, respectively. The median overall survival was 72.5 days (95% confidence interval 36-122) with 30% expiring within 30 days and only 13.8% surviving more than 1 year. There were no differences in median overall survival between sites (p=0.37) despite differences in time from diagnosis of NM to Ommaya reservoir placement (p

ISSN

1532-2653

First Page

1467

Last Page

1472

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