Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model.
Document Type
Article
Publication Date
1-1-2016
Institution/Department
Center for Molecular Medicine, Maine Medical Center Research Institute
Journal Title
Methods in molecular biology (Clifton, N.J.)
MeSH Headings
Animals, Cell Line, Tumor, Cell Transformation, Neoplastic, Chick Embryo, Chorioallantoic Membrane, Humans, Neovascularization, Pathologic, X-Ray Microtomography
Abstract
Models of tumor angiogenesis have played a critical role in understanding the mechanisms involved in the recruitment of vasculature to the tumor mass, and have also provided a platform for testing antiangiogenic potential of new therapeutics that combat the development of malignant growth. In this regard, the chorioallantoic membrane (CAM) of the developing chick embryo has proven to be an elegant model for investigation of angiogenic processes. Here, we describe methods for effectively utilizing the preestablished vascular network of the chick CAM to investigate and quantify tumor-associated angiogenesis in a breast tumor model.
ISSN
1940-6029
First Page
255
Last Page
269
Recommended Citation
Ames, Jacquelyn J; Henderson, Terry; Liaw, Lucy; and Brooks, Peter C, "Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model." (2016). Maine Medical Center. 826.
https://knowledgeconnection.mainehealth.org/mmc/826
