Nonclassically secreted regulators of angiogenesis.

Document Type

Article

Publication Date

2-28-2013

Institution/Department

MMCRI

Journal Title

Angiology : open access

MeSH Headings

Peptides

Abstract

Many secreted polypeptide regulators of angiogenesis are devoid of signal peptides. These proteins are released through nonclassical pathways independent of endoplasmic reticulum and Golgi. In most cases, the nonclassical protein export is induced by stress. It usually serves to stimulate repair or inflammation in damaged tissues. We review the secreted signal peptide-less regulators of angiogenesis and discuss the mechanisms and biological significance of their unconventional export.

ISSN

2329-9495

First Page

1000101

Last Page

1000101

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