“CORE conducts innovative research focused on health services, quality and safety, and patient-centered outcomes. Our investigator-initiated research is complemented by our service and educational missions, which extend to Maine Medical Center, MaineHealth, and Tufts University School of Medicine.”

~ Paul K. J. Han, MD, MA, MPH, Director
Center for Outcomes Research & Evaluation (CORE)

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Submissions from 2018

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Variations in hospice utilization and length of stay for Medicare patients with melanoma, Rebecca N. Hutchinson, F Lee Lucas, Mary Becker, Heidi R. Wierman, and Kathleen M. Fairfield

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Systematic review of the volume-outcome relationship for radical prostatectomy., Jeffrey J Leow, Eugene K Leong, Emily C Serrell, Steven L Chang, Russell L Gruen, Keng Siang Png, Lisa T Beaule, Quoc-Dien Trinh, Mani M Menon, and Jesse D Sammon

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Re: Woonyoung Choi, Andrea Ochoa, David J. McConkey, et al. Genetic alterations in the molecular subtypes of bladder cancer: illustration in the cancer genome atlas dataset. European Urology 2017;72:354-65., Joshua A Linscott, Angela B Smith, and Jesse D Sammon

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Variation in the use of active surveillance for low-risk prostate cancer., Björn Löppenberg, David F Friedlander, Anna Krasnova, Andrew Tam, Jeffrey J Leow, Paul L Nguyen, Hawa Barry, Stuart R Lipsitz, Mani Menon, Firas Abdollah, Jesse D. Sammon, Maxine Sun, Toni K Choueiri, Adam S Kibel, and Quoc-Dien Trinh

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Behavioral outcomes of specialized psychiatric hospitalization in the autism inpatient collection (AIC): a multisite comparison., Kahsi A Pedersen, Susan L Santangelo, Robin L Gabriels, Giulia Righi, Michael Erard, and Matthew Siegel

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The association between mortality and distance to treatment facility in patients with muscle invasive bladder cancer., Stephen Ryan, Emily C Serrell, Patrick Karabon, Gregory Mills, Moritz Hansen, Matthew Hayn, Mani Menon, Quoc-Dien Trinh, Firas Abdollah, and Jesse D Sammon

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Prostate cancer screening in early Medicaid expansion states., Jesse D Sammon, Emily C Serrell, Patrick Karabon, Jeffrey J Leow, Firas Abdollah, Joel S Weissman, Paul K J Han, Moritz Hansen, Mani Menon, and Quoc-Dien Trinh

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Review of the comparative effectiveness of radical prostatectomy, radiation therapy, or expectant management of localized prostate cancer in registry data., Emily C Serrell, Daniel Pitts, Matthew Hayn, Lisa Beaule, Moritz H Hansen, and Jesse D Sammon

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Examination of the patient-focused impact of cancer telegenetics among a rural population: comparison with traditional in-person services., Nan M Solomons, Amanda E Lamb, Frances L Lucas, Eileen F McDonald, and Susan Miesfeldt

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State-by-state variation in prostate-specific antigen screening trends following the 2011 United States Preventive Services Task Force panel update., Malte W Vetterlein, Deepansh Dalela, Jesse D Sammon, Patrick Karabon, Akshay Sood, Tarun Jindal, Christian P Meyer, Björn Löppenberg, Maxine Sun, Quoc-Dien Trinh, Mani Menon, and Firas Abdollah

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Reply., Malte W Vetterlein, Jesse D Sammon, and Firas Abdollah

Submissions from 2017

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Communicating uncertainty in benefits and harms: a review of patient decision support interventions., Nick Bansback, Madelaine Bell, Luke Spooner, Alysa Pompeo, Paul K J Han, and Mark Harrison

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PUGS: A novel scale to assess perceptions of uncertainties in genome sequencing., B B Biesecker, S W Woolford, W M P Klein, K B Brothers, K L Umstead, K L Lewis, L G Biesecker, and P K J Han

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The use of prostate specific antigen screening in purchased versus direct care settings: data from the TRICARE® military database., Alexander P Cole, Wei Jiang, Stuart R Lipsitz, Peter A Learn, Maxine Sun, Toni K Choueiri, Paul L Nguyen, Adam S Kibel, Mani Menon, Jesse D Sammon, Tracey Koehlmoos, Adil Haider, and Quoc-Dien Trinh

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Public perceptions of expert disagreement: Bias and incompetence or a complex and random world?, Nathan F Dieckmann, Branden B Johnson, Robin Gregory, Marcus Mayorga, Paul K J Han, and Paul Slovic

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Cancer incidence in patients with hereditary hemorrhagic telangiectasia., Christine W. Duarte, Adam W. Black, F Lee Lucas, and Calvin P H Vary

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A three-talk model for shared decision making: multistage consultation process., Glyn Elwyn, Marie Anne Durand, Julia Song, Johanna Aarts, Paul J Barr, Zackary Berger, Nan Cochran, Dominick Frosch, Dariusz Galasiński, Pål Gulbrandsen, Paul K J Han, Martin Härter, Paul Kinnersley, Amy Lloyd, Manish Mishra, Lilisbeth Perestelo-Perez, Isabelle Scholl, Kounosuke Tomori, Lyndal Trevena, Holly O Witteman, and Trudy Van der Weijden

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Disclosing the uncertainty associated with prognostic estimates in breast cancer., Ellen G Engelhardt, Arwen H Pieterse, Paul K J Han, Nanny van Duijn-Bakker, Frans Cluitmans, Ed Maartense, Monique M E M Bos, Nir I Weijl, Cornelis J A Punt, Patricia Quarles van Ufford-Mannesse, Harm Sleeboom, Johanneke E A Portielje, Koos J M van der Hoeven, F J Sherida Woei-A-Jin, Judith R Kroep, Hanneke C J M de Haes, Ellen M A Smets, and Anne M Stiggelbout

Relationships Between Lung Cancer Mortality and Smoking, Education and Poverty in a Rural State., Kathleen M. Fairfield, Adam Black, Kimberly Murray, Erika Ziller, Leo B. Waterston, F L. Lucas, and Paul Han

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Valproate for agitation in critically ill patients: a retrospective study., David J. Gagnon, Gabriel V Fontaine, Kathryn E. Smith, Richard R. Riker, Russell R Miller, Patricia A. Lerwick, F L. Lucas, John T. Dziodzio, Kristen C. Sihler, and Gilles L. Fraser

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Harms of cervical cancer screening in the United States and the Netherlands., Dik Habbema, Sheila Weinmann, Marc Arbyn, Aruna Kamineni, Andrew E Williams, Inge M C M de Kok, Folkert van Kemenade, Terry S Field, Joost van Rosmalen, and Martin L Brown

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A taxonomy of medical uncertainties in clinical genome sequencing., Paul K J Han, Kendall L Umstead, Barbara A Bernhardt, Robert C Green, Steven Joffe, Barbara Koenig, Ian Krantz, Leo B Waterston, Leslie G Biesecker, and Barbara B Biesecker

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Using the surprise question to identify those with unmet palliative care needs in emergency and inpatient settings: what do clinicians think?, Samir A Haydar, Lisa Almeder, Lauren Michalakes, Paul K J Han, and Tania D Strout

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How long do I have? Observational study on communication about life expectancy with advanced cancer patients., I Henselmans, E M A Smets, P K J Han, H C J C de Haes, and H W M van Laarhoven

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The evolution of uncertainty in second opinions about prostate cancer treatment., Marij A Hillen, Caitlin M Gutheil, Ellen M A Smets, Moritz Hansen, Terrence M Kungel, Tania D Strout, and Paul K J Han

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Tolerance of uncertainty: conceptual analysis, integrative model, and implications for healthcare., Marij A Hillen, Caitlin M Gutheil, Tania D Strout, Ellen M A Smets, and Paul K J Han

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Racial differences in prostate-specific antigen-based prostate cancer screening: state-by-state and region-by-region analyses., Tarun Jindal, Naveen Kachroo, Jesse Sammon, Deepansh Dalela, Akshay Sood, Malte W Vetterlein, Patrick Karabon, Wooju Jeong, Mani Menon, Quoc-Dien Trinh, and Firas Abdollah

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Variation in locoregional prostate cancer care and treatment trends at commission on cancer designated facilities: a national cancer data base analysis 2004 to 2013., Björn Löppenberg, Akshay Sood, Deepansh Dalela, Patrick Karabon, Jesse D Sammon, Malte W Vetterlein, Joachim Noldus, James O Peabody, Quoc-Dien Trinh, Mani Menon, and Firas Abdollah

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Factors associated with deciding between risk-reducing salpingo-oophorectomy and ovarian cancer screening among high-risk women enrolled in GOG-0199: an NRG Oncology/Gynecologic Oncology Group study., Phuong L Mai, Marion Piedmonte, Paul K Han, Richard P Moser, Joan L Walker, Gustavo Rodriguez, John Boggess, Thomas J Rutherford, Oliver Zivanovic, David E Cohn, J Tate Thigpen, Robert M Wenham, Michael L Friedlander, Chad A Hamilton, Jamie Bakkum-Gamez, Alexander B Olawaiye, Martee L Hensley, Mark H Greene, Helen Q Huang, and Lari Wenzel

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Cardio-oncology: the role of big data., Anant Mandawat, Andrew E Williams, and Sanjeev A Francis

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Screening for behavioral health conditions in primary care settings: a systematic review of the literature., Norah Mulvaney-Day, Tina Marshall, Kathryn Downey Piscopo, Neil Korsen, Sean Lynch, Lucy H Karnell, Garrett E Moran, Allen S Daniels, and Sushmita Shoma Ghose

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A prospective evaluation of the candle wax sign: a visual clue to diagnose aggressive basal cell carcinoma., Brian Patrick O'Donnell and Christine W Duarte

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Healthcare policy and urologic practice., Daniel Pitts and Jesse D Sammon

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First-trimester chorionic bump--association with fetal aneuploidy in a high-risk population., Joseph R Wax, Angelina Cartin, Christian Litton, Michael G Pinette, and F L Lucas

Submissions from 2016

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Unknown risks: parental hesitation about vaccination., Laura L Blaisdell, Caitlin Gutheil, Norbert A M Hootsmans, and Paul K J Han

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Conflicting health information: a critical research need., Delesha M Carpenter, Lorie L Geryk, Annie T Chen, Rebekah H Nagler, Nathan F Dieckmann, and Paul K J Han

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A multistate model predicting mortality, length of stay, and readmission for surgical patients., David E Clark, Kaitlin R Ostrander, and Brad M Cushing

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Medication-related self-management behaviors among arthritis patients: does attentional coping style matter?, Lorie L Geryk, Susan J Blalock, Robert F DeVellis, Joanne M Jordan, Paul K J Han, and Delesha M Carpenter

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Shared decision-making as an existential journey: aiming for restored autonomous capacity., Pål Gulbrandsen, Marla L Clayman, Mary Catherine Beach, Paul K. Han, Emily F Boss, Eirik H Ofstad, and Glyn Elwyn

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Development and evaluation of the "BRISK Scale," a brief observational measure of risk communication competence., Paul K J Han, Katherine Joekes, Greg Mills, Caitlin Gutheil, Kahsi Smith, Nancy E Cochran, and Glyn Elwyn

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Knowledge and values for cancer screening decisions: results from a national survey., Richard M Hoffman, Joann G Elmore, Michael P Pignone, Bethany S Gerstein, Carrie A Levin, and Kathleen M Fairfield

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Difference in effectiveness of medication adherence intervention by health literacy level., Ashli A Owen-Smith, David H Smith, Cynthia S Rand, Jeffrey O Tom, Reesa Laws, Amy Waterbury, Andrew Williams, and William M Vollmer

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Prostate cancer: radiotherapy might improve survival, even in the oldest men., Stephen T. Ryan and Jesse D. Sammon

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Determinants of cancer screening in Asian-Americans., Quoc-Dien Trinh, Hanhan Li, Christian P Meyer, Julian Hanske, Toni K Choueiri, Gally Reznor, Stuart R Lipsitz, Adam S Kibel, Paul K. Han, Paul L Nguyen, Mani Menon, and Jesse D Sammon

Submissions from 2015

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High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes., Joshua C Anderson, Christopher D Willey, Amitkumar Mehta, Karim Welaya, Dongquan Chen, Christine W Duarte, Pooja Ghatalia, Waleed Arafat, Ankit Madan, Sunil Sudarshan, Gurudatta Naik, William E Grizzle, Toni K Choueiri, and Guru Sonpavde

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Validation of the Patient-Reported Outcome Mortality Prediction Tool (PROMPT)., Christine W Duarte, Adam W Black, Kimberly Murray, Amy E Haskins, Lee Lucas, Sarah Hallen, and Paul K J Han

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Decisions about medication use and cancer screening across age groups in the United States., Kathleen M Fairfield, Bethany S Gerstein, Carrie A Levin, Vickie Stringfellow, Heidi R Wierman, and Mary McNaughton-Collins

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Severity of anemia predicts hospital length of stay but not readmission in patients with chronic kidney disease: a retrospective cohort study., Katherine Garlo, Deanna Williams, Lee Lucas, Rocket Wong, Joel Botler, Stuart Abramson, and Mark G Parker

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Physicians' perceptions of the value of prognostic models: the benefits and risks of prognostic confidence., Sarah A M Hallen, Norbert A M Hootsmans, Laura Blaisdell, Caitlin M Gutheil, and Paul K J Han

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Genetic information-seeking behaviors and knowledge among family members and patients with inherited bone marrow failure syndromes., Jada G Hamilton, Sadie P Hutson, Amy E Frohnmayer, Paul K J Han, June A Peters, Ann G Carr, and Blanche P Alter

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Delivering a decision support intervention about PSA screening to patients outside of clinical encounters is ineffective in promoting informed decision-making., Paul K J Han

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Temporal changes in tolerance of uncertainty among medical students: insights from an exploratory study., Paul K J Han, Daniel Schupack, Susannah Daggett, Christina T Holt, and Tania D Strout

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The use of haematopoietic stem cell transplantation in Fanconi anaemia patients: a survey of decision making among families in the US and Canada., Sadie P Hutson, Paul K J Han, Jada G Hamilton, Sean C Rife, Mohamad M Al-Rahawan, Richard P Moser, Seth P Duty, Sheeba Anand, and Blanche P Alter

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Characterizing participants in the ClinSeq genome sequencing cohort as early adopters of a new health technology., Katie L Lewis, Paul K J Han, Gillian W Hooker, William M P Klein, Leslie G Biesecker, and Barbara B Biesecker

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Evaluating adverse rural crash outcomes using the NHTSA State Data System., Christine Peura, Joseph A Kilch, and David E Clark

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Effects of false-positive cancer screenings and cancer worry on risk-reducing surgery among BRCA1/2 carriers., David B Portnoy, Jennifer T Loud, Paul K J Han, Phuong L Mai, and Mark H Greene

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Decision making and cancer., Valerie F Reyna, Wendy L Nelson, Paul K Han, and Michael P Pignone

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Noninvasive prenatal testing: the importance of pretest trisomy risk and posttest predictive values., Joseph R Wax, Renee Chard, Angelina Cartin, Christian Litton, Michael G Pinette, and F Lee Lucas

Submissions from 2014

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How do research participants perceive "uncertainty" in genome sequencing?, Barbara B Biesecker, William Klein, Katie L Lewis, Tyler C Fisher, Martha Frances Wright, Leslie G Biesecker, and Paul K Han

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The effect of hospital care on early survival after penetrating trauma., David E Clark, Peter C Doolittle, Robert J Winchell, and Rebecca A Betensky

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Developing, evaluating and validating a scoring rubric for written case reports., Peggy R Cyr, Kahsi A Smith, India L Broyles, and Christina T Holt

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Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia., Christine W Duarte, Kimberly Murray, F Lee Lucas, Kathleen Fairfield, Heather Miller, Peter Brooks, and Calvin P H Vary

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Intraperitoneal chemotherapy among women in the Medicare population with epithelial ovarian cancer., Kathleen M Fairfield, Kimberly Murray, Jason A LaChance, Heidi R Wierman, Craig C Earle, Edward L Trimble, and Joan L Warren

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Relationship between regional spending on vascular care and amputation rate., Philip P Goodney, Lori L Travis, Benjamin S Brooke, Randall R DeMartino, David C Goodman, Elliott S Fisher, and John D Birkmeyer

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Development and evaluation of a risk communication curriculum for medical students., Paul K J Han, Katherine Joekes, Glyn Elwyn, Kathleen M Mazor, Richard Thomson, Philip Sedgwick, Judith Ibison, and John B Wong

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Individual differences in aversion to ambiguity regarding medical tests and treatments: association with cancer screening cognitions., Paul K J Han, Andrew E Williams, Amy Haskins, Caitlin Gutheil, F Lee Lucas, William M P Klein, and Kathleen M Mazor

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Development of clinical models for predicting erectile function after localized prostate cancer treatment., Amy E Haskins, Paul K J Han, Frances L Lucas, Ian Bristol, and Moritz Hansen

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Lack of shared decision making in cancer screening discussions: results from a national survey., Richard M Hoffman, Joann G Elmore, Kathleen M Fairfield, Bethany S Gerstein, Carrie A Levin, and Michael P Pignone

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Perceived ambiguity, fatalism, and believing cancer is more prevalent than heart disease., William M P Klein, Rebecca A Ferrer, Kaitlin A Graff, Annette R Kaufman, and Paul K J Han

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Perceptions of cancer as a death sentence: prevalence and consequences., Richard P Moser, Jamie Arndt, Paul K Han, Erika A Waters, Marni Amsellem, and Bradford W Hesse

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Effects of a renal rehabilitation exercise program in patients with CKD: a randomized, controlled trial., Ana P Rossi, Debra D Burris, F Leslie Lucas, Gail A Crocker, and James C Wasserman

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Clinical impact of sacroplasty on patient mobility., Jennifer Talmadge, Kahsi Smith, Thomas Dykes, and Derek Mittleider