Submission Type

Original Research


Introduction: Given the uncertainties with IV iron therapy and potential risk of infection, there may be hesitation to treat hospitalized patients with bacterial infections with this preparation even if clinically indicated. The aim of this study was to examine patterns of prescribing IV iron in hospitalized patients being treated for a bacterial infection and associated clinical outcomes in those with severe infections.

Methods: This retrospective chart review evaluated adult patients who received both IV iron sucrose and antibiotics during the same admission at Maine Medical Center during 2019. Data collected included iron studies and IV iron prescribing practices. Clinical outcomes were collected on patients with severe infections. Data were summarized using descriptive statistics.

Results: A total of 202 patients were evaluated. The median duration of antibiotic therapy was 5 (4-9) days. There was overlap between iron and antibiotic administration in 153 (75.7%) patients with a mean overlap duration of 2.7 (1-7) days. In the 49 instances without overlap, 20 (41%) received IV iron before antibiotics. 20 (10%) patients had a severe infection, the majority (75%) of patients with severe infection had antibiotic and iron overlap and no patients had new MRSA colonization. Two patients with severe infection died during hospitalization and two were readmitted within 30 days of discharge.

Conclusion: This study shows that IV iron is frequently prescribed in patients in the setting of acute bacterial infection in our facility. Patients with severe infection did not appear to have negative outcomes when overlap existed between antibiotics and IV iron.



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