Irisin directly stimulates osteoclastogenesis and bone resorption

Authors

Eben G Estell, Maine Medical Center
Phuong T Le, Maine Medical Center
Yosta Vegting, Maine Medical Center
Hyeonwoo Kim
Christiane Wrann
Mary L Bouxsein
Kenichi Nagano
Roland Baron
Bruce M Spiegelman
Clifford J Rosen, Maine Medical CenterFollow

Document Type

Article

Publication Date

8-11-2020

Institution/Department

Maine Medical Center Research Institute

Journal Title

Elife

MeSH Headings

Osteoclasts, Osteogenesis, Bone Resorption, Central Nervous System Stimulants

Abstract

The myokine irisin facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In the current study we investigated whether irisin also directly regulates osteoclasts.

ISSN

2050-084X

Recommended Citation

Estell, Eben G; Le, Phuong T; Vegting, Yosta; Kim, Hyeonwoo; Wrann, Christiane; Bouxsein, Mary L; Nagano, Kenichi; Baron, Roland; Spiegelman, Bruce M; and Rosen, Clifford J, "Irisin directly stimulates osteoclastogenesis and bone resorption" (2020). MaineHealth Maine Medical Center. 1890.
https://knowledgeconnection.mainehealth.org/mmc/1890