Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging

Rosaly Correa-de-Araujo, Division of Geriatrics and Clinical Gerontology, National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, United States.
Odessa Addison, Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore, Geriatric Research, Education and Clinical Center (GRECC), Baltimore, MD, United States.
Iva Miljkovic, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.
Bret H. Goodpaster, AdventHealth Translational Research Institute, Orlando, FL, United States.
Bryan C. Bergman, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Richard V. Clark, United States Anti-Doping Agency, Colorado Springs, CO, United States.
Joanne W. Elena, National Cancer Institute, National Institutes of Health, U.S Department of Health and Human Services, Bethesda, MD, United States.
Karyn A. Esser, Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States.
Luigi Ferrucci, Intramural Research Program, National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, United States.
Michael O. Harris-Love, Physical Therapy Program, Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Steve B. Kritchevsky, Sticht Center for Healthy Aging and Alzheimer's Prevention Wake Forest School of Medicine, Winston-Salem, NC, United States.
Amanda Lorbergs, Canadian Frailty Network, Kingston, ON, Canada.
John A. Shepherd, Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States.
Gerald I. Shulman, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States.
Clifford J. Rosen, The Maine Medical Center Research Institute, Scarborough, ME, United States.Follow

Document Type

Article

Publication Date

8-7-2020

Institution/Department

MaineHealth Institute for Research

Journal Title

Frontiers in Physiology

Abstract

Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An interdisciplinary workshop convened by the National Institute on Aging Division of Geriatrics and Clinical Gerontology on September 2018, discussed myosteatosis in the context of skeletal muscle function deficit (SMFD). Its purpose was to gain a better understanding of the roles of myosteatosis in aging muscles and metabolic disease, particularly its potential determinants and clinical consequences, and ways of properly assessing it. Special attention was given to functional status and standardization of measures of body composition (including the value of D-creatine dilution method) and imaging approaches [including ways to better use dual-energy X-ray absorptiometry (DXA) through the shape and appearance modeling] to assess lean mass, sarcopenia, and myosteatosis. The workshop convened innovative new areas of scientific relevance to light such as the effect of circadian rhythms and clock disruption in skeletal muscle structure, function, metabolism, and potential contribution to increased myosteatosis. A muscle-bone interaction perspective compared mechanisms associated with myosteatosis and bone marrow adiposity. Potential preventive and therapeutic approaches highlighted ongoing work on physical activity, myostatin treatment, and calorie restriction. Myosteatosis' impact on cancer survivors raised new possibilities to identify its role and to engage in cross-disciplinary collaboration. A wide range of research opportunities and challenges in planning for the most appropriate study design, interpretation, and translation of findings into clinical practice were discussed and are presented here.

ISSN

1664-042X

First Page

963

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