"The number of circulating CD26 expressing cells is decreased in critic" by Joanne T. deKay, Teresa L. May et al.
 

The number of circulating CD26 expressing cells is decreased in critical COVID-19 illness

Document Type

Article

Publication Date

3-4-2022

Institution/Department

Pulmonology; MaineHealth Institute for Research; Center for Molecular Medicine

Journal Title

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Abstract

We evaluated the number of CD26 expressing cells in peripheral blood of patients with COVID-19 within 72 h of admission and on day 4 and day 7 after enrollment. The majority of CD26 expressing cells were presented by CD3 CD4 lymphocytes. A low number of CD26 expressing cells were found to be associated with critical-severity COVID-19 disease. Conversely, increasing numbers of CD26 expressing T cells over the first week of standard treatment was associated with good outcomes. Clinically, the number of circulating CD26 cells might be a marker of recovery or the therapeutic efficacy of anti-COVID-19 treatment. New therapies aimed at preserving and increasing the level of CD26 expressing T cells may prove useful in the treatment of COVID-19 disease.

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