Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells.

Authors

Matthew D Lynes, Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA.,Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.Follow
Diana L Carlone, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Kristy L Townsend, Department of Neurological Surgery, The Ohio State University, Columbus, OH, USA
David T Breault, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA. Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Yu-Hua Tseng, Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA,Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

Document Type

Article

Publication Date

3-3-2022

Journal Title

Stem cells (Dayton, Ohio)

MeSH Headings

Adipogenesis, Adipose Tissue, Animals, Cell Differentiation, Mice, Stem Cells, Telomerase

Abstract

In adult tissues such as adipose tissue, post-mitotic cells like adipocytes can be replaced by differentiation of a population of tissue-resident stem cells. Expression of mouse telomerase reverse transcriptase (mTert) is a hallmark of stem cell populations, and previous efforts to identify tissue-resident adult stem cells by measuring mTert expression have increased our understanding of stem cell biology significantly. Here, we used a doxycycline-inducible mouse model to perform longitudinal, live-animal lineage-tracing of mTert-expressing cells for more than 1 year. We identified a rare (

ISSN

1549-4918

First Page

102

Last Page

111

Recommended Citation

Lynes MD, Carlone DL, Townsend KL, Breault DT, Tseng YH. Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem Cells. 2022;40(1):102-111. doi:10.1093/stmcls/sxab005