Thoracoscopic lobectomy is associated with acceptable morbidity and mortality in patients with predicted postoperative forced expiratory volume in 1 second or diffusing capacity for carbon monoxide less than 40% of normal.
Document Type
Article
Publication Date
7-1-2014
Institution/Department
Surgery
Journal Title
The Journal of thoracic and cardiovascular surgery
MeSH Headings
Aged, Female, Forced Expiratory Volume, Humans, Lung, Lung Neoplasms, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Pneumonectomy, Propensity Score, Pulmonary Diffusing Capacity, Retrospective Studies, Risk Factors, Thoracic Surgery, Video-Assisted, Time Factors, Treatment Outcome
Abstract
OBJECTIVE: A predicted postoperative (ppo) forced expiratory volume in 1 second (FEV1%) or diffusing capacity of the lung for carbon monoxide (DLCO%) of
METHODS: PpoFEV1% and ppoDLCO% were calculated for patients undergoing open or VATS lobectomy for lung cancer in the Society of Thoracic Surgeons General Thoracic database from 2009 to 2011. Univariate comparisons, multivariate analyses, and 1:1 propensity matching were performed.
RESULTS: A total of 13,376 patients underwent lobectomy (50.9% open, 49.1% VATS). A decreased ppoFEV1% and ppoDLCO% were each independent predictors for both cardiopulmonary complications and mortality in the open group (all P ≤ .008). In the VATS group, ppoFEV1% was an independent predictor of complications (P = .001) but not mortality (P = .77), and ppoDLCO% was an independent predictor of complications (P = .046) and mortality (P = .008). With decreasing ppoFEV1% or ppoDLCO%, complications and mortality increased at a greater rate in the open lobectomy than in a propensity-matched VATS group (n = 4215 each). For patients with ppoFEV1% < 40%, mortality was greater in the open (4.8%) than in the matched VATS group (0.7%, P = .003). Similar results were seen for ppoDLCO% < 40% (5.2% open, 2.0% VATS, P = .003). The rate of complications was significantly greater at ppoFEV1% < 40% in the open (21.9%) than in the matched VATS (12.8%, P = .005) group and similar results were seen with ppoDLCO% < 40% (14.9% open, 10.4% VATS, P = .016).
CONCLUSIONS: VATS lobectomy can be performed with acceptable rates of morbidity and mortality in patients with reduced ppoFEV1% or ppoDLCO%.
ISSN
1097-685X
First Page
19
Last Page
28
Recommended Citation
Burt, Bryan M; Kosinski, Andrzej S; Shrager, Joseph B; Onaitis, Mark W; and Weigel, Tracey, "Thoracoscopic lobectomy is associated with acceptable morbidity and mortality in patients with predicted postoperative forced expiratory volume in 1 second or diffusing capacity for carbon monoxide less than 40% of normal." (2014). MaineHealth Maine Medical Center. 229.
https://knowledgeconnection.mainehealth.org/mmc/229