Caffeine intake and the risk of kidney stones.
Document Type
Article
Publication Date
12-2014
Institution/Department
Nephrology
Journal Title
The American journal of clinical nutrition
MeSH Headings
Adult, Aged, Body Mass Index, Caffeine, Calcium, Calcium Oxalate, Female, Follow-Up Studies, Humans, Incidence, Kidney Calculi, Life Style, Linear Models, Male, Middle Aged, Multivariate Analysis, Potassium, Prospective Studies, Risk Factors, Surveys and Questionnaires, Uric Acid
Abstract
BACKGROUND: Although caffeine intake may increase urine calcium excretion, caffeine-containing beverages have been associated with a lower risk of nephrolithiasis.
OBJECTIVE: We sought to determine the association between caffeine intake and the risk of incident kidney stones in 3 large prospective cohorts.
DESIGN: We prospectively analyzed the association between intake of caffeine and incidence of kidney stones in 3 large ongoing cohort studies, the Health Professionals Follow-Up Study (HPFS) and the Nurses' Health Studies (NHS) I and II. Information on the consumption of caffeine and the incidence of kidney stones was collected by validated questionnaires.
RESULTS: The analysis included 217,883 participants; over a median follow-up of >8 y, 4982 incident cases occurred. After multivariate adjustment for age, BMI, fluid intake, and other factors, participants in the highest quintile of caffeine intake had a 26% (95% CI: 12%, 38%) lower risk of developing stones in the HPFS cohort, a 29% lower risk (95% CI: 15%, 41%) in the NHS I cohort, and a 31% lower risk (95% CI: 18%, 42%) in the NHS II cohort (P-trend < 0.001 for all cohorts). The association remained significant in the subgroup of participants with a low or no intake of caffeinated coffee in the HPFS cohort. Among 6033 participants with 24-h urine data, the intake of caffeine was associated with higher urine volume, calcium, and potassium and with lower urine oxalate and supersaturation for calcium oxalate and uric acid.
CONCLUSION: Caffeine intake is independently associated with a lower risk of incident kidney stones.
ISSN
1938-3207
First Page
1596
Last Page
1603
Recommended Citation
Ferraro, Pietro Manuel; Taylor, Eric N; Gambaro, Giovanni; and Curhan, Gary C, "Caffeine intake and the risk of kidney stones." (2014). MaineHealth Maine Medical Center. 70.
https://knowledgeconnection.mainehealth.org/mmc/70