Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells.
Stem cells (Dayton, Ohio)
Adipogenesis, Adipose Tissue, Animals, Cell Differentiation, Mice, Stem Cells, Telomerase
In adult tissues such as adipose tissue, post-mitotic cells like adipocytes can be replaced by differentiation of a population of tissue-resident stem cells. Expression of mouse telomerase reverse transcriptase (mTert) is a hallmark of stem cell populations, and previous efforts to identify tissue-resident adult stem cells by measuring mTert expression have increased our understanding of stem cell biology significantly. Here, we used a doxycycline-inducible mouse model to perform longitudinal, live-animal lineage-tracing of mTert-expressing cells for more than 1 year. We identified a rare (
Lynes MD, Carlone DL, Townsend KL, Breault DT, Tseng YH. Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem Cells. 2022;40(1):102-111. doi:10.1093/stmcls/sxab005