The Center for Molecular Medicine (CMM) was established in 1997 as a Center within Maine Medical Center Research Institute with the vision of performing cutting edge biomedical research to discover the molecular mechanisms of human disease, and to harness new knowledge in developmental biology and stem cells for regenerative medicine approaches. The investigators at CMM are committed to translating basic science discoveries to innovative approaches to diagnose and treat human disease.

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Submissions from 2015

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A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development., S Castillo-Lluva, L Hontecillas-Prieto, A Blanco-Gómez, M Del Mar Sáez-Freire, B García-Cenador, J García-Criado, M Pérez-Andrés, A Orfao, M Cañamero, J H Mao, T Gridley, A Castellanos-Martín, and J Pérez-Losada

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3,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects?, Arturo Hernandez

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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium., Katja Horvay, Thierry Jardé, Franca Casagranda, Victoria M Perreau, Katharina Haigh, Christian M Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J Haigh, Nick Barker, Jose M Polo, Gary R Hime, and Helen E Abud

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AHNAK2 participates in the stress-induced nonclassical FGF1 secretion pathway., Aleksandr Kirov, Doreen Kacer, Barbara A Conley, Calvin P H Vary, and Igor Prudovsky

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Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski

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Emerging EPO and EPO receptor regulators and signal transducers., David Kuhrt and Don M Wojchowski

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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron., Nils O Lindström, Melanie L Lawrence, Sally F Burn, Jeanette A Johansson, Elvira R M Bakker, Rachel A Ridgway, C-Hong Chang, Michele J Karolak, Leif Oxburgh, Denis J Headon, Owen J Sansom, Ron Smits, Jamie A Davies, and Peter Hohenstein

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p53 Enables metabolic fitness and self-renewal of nephron progenitor cells., Yuwen Li, Jiao Liu, Wencheng Li, Aaron Brown, Melody Baddoo, Marilyn Li, Thomas Carroll, Leif Oxburgh, Yumei Feng, and Zubaida Saifudeen

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SMAD1 and SMAD5 expression is coordinately regulated by FLI1 and GATA2 during endothelial development., Jonathon Marks-Bluth, Anchit Khanna, Vashe Chandrakanthan, Julie Thoms, Thomas Bee, Christina Eich, Young Chan Kang, Kathy Knezevic, Qiao Qiao, Simon Fitch, Leif Oxburgh, Katrin Ottersbach, Elaine Dzierzak, Marella F T R de Bruijn, and John E Pimanda

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Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells., Sree Deepthi Muthukrishnan, Xuehui Yang, Robert Friesel, and Leif Oxburgh

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Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis., David T Paik, Meena Rai, Sergey Ryzhov, Lehanna N Sanders, Omonigho Aisagbonhi, Mitchell J Funke, Igor Feoktistov, and Antonis K Hatzopoulos

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Parent stem cells can serve as niches for their daughter cells., Ana Pardo-Saganta, Purushothama Rao Tata, Brandon M Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley, and Jayaraj Rajagopal

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DLL4/Notch1 and BMP9 interdependent signaling induces human endothelial cell quiescence via P27KIP1 and thrombospondin-1., Bahman Rostama, Jacqueline E Turner, Guy T Seavey, Christine R Norton, Thomas Gridley, Calvin P H Vary, and Lucy Liaw

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Cthrc1 controls adipose tissue formation, body composition, and physical activity., J Patrizia Stohn, Qiaozeng Wang, Matthew E Siviski, Kevin Kennedy, Yong-Ri Jin, Doreen Kacer, Victoria DeMambro, Lucy Liaw, Calvin P Vary, Clifford J Rosen, Igor Prudovsky, and Volkhard Lindner

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SLUG is a direct transcriptional repressor of PTEN tumor suppressor., Berna Uygur, Katrina Abramo, Evgenia Leikina, Calvin Vary, Lucy Liaw, and Wen-Shu Wu

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Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors., Ana Villarejo, Patricia Molina-Ortiz, Yenny Montenegro, Gema Moreno-Bueno, Saleta Morales, Vanesa Santos, Tom Gridley, Mirna A Pérez-Moreno, Héctor Peinado, Francisco Portillo, Carmela Calés, and Amparo Cano

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Fibroblast growth factor signaling in the vasculature., Xuehui Yang, Lucy Liaw, Igor Prudovsky, Peter C Brooks, Calvin Vary, Leif Oxburgh, and Robert Friesel

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BMP9 crosstalk with the hippo pathway regulates endothelial cell matricellular and chemokine responses., Kira Young, Eric Tweedie, Barbara Conley, Jacquelyn Ames, MaryLynn FitzSimons, Peter Brooks, Lucy Liaw, and Calvin P H Vary

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Expression of adenosine receptors in monocytes from patients with bronchial asthma., Ksenia Yuryeva, Irina Saltykova, Ludmila Ogorodova, Natalya Kirillova, Evgeny Kulikov, Elena Korotkaya, Yulia Iakovleva, Igor Feoktistov, Alexey Sazonov, and Sergey Ryzhov

Submissions from 2014

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Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia., Christine W Duarte, Kimberly Murray, F Lee Lucas, Kathleen Fairfield, Heather Miller, Peter Brooks, and Calvin P H Vary

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Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors., Christine W Duarte, J Patrizia Stohn, Qiaozeng Wang, Ivette F Emery, Andrew Prueser, and Volkhard Lindner

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Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia., Amanda J Favreau, Calvin P H Vary, Peter C Brooks, and Pradeep Sathyanarayana

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FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney., Jennifer L Fetting, Justin A Guay, Michele J Karolak, Renato V Iozzo, Derek C Adams, David E Maridas, Aaron C Brown, and Leif Oxburgh

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Overview of genetic tools and techniques to study Notch signaling in mice., Thomas Gridley and Andrew K Groves

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Lightening up a notch: notch regulation of energy metabolism., Thomas Gridley and Shingo Kajimura

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Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis., Xiang Hua Han, Yong-Ri Jin, Leonard Tan, Tatiana Kosciuk, Jin-Seon Lee, and Jeong Kyo Yoon

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Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity., Qing He, Xuehui Yang, Yan Gong, Dmitry Kovalenko, Ernesto Canalis, Clifford J Rosen, and Robert E Friesel

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Effect of sustained postnatal systemic inflammation on hippocampal volume and function in mice., Shadi N Malaeb, Jonathan M Davis, Ilka M Pinz, Jennifer L Newman, Olaf Dammann, and Maribel Rios

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Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions., M Elena Martinez, Marika Charalambous, Aabida Saferali, Steven Fiering, Anna K Naumova, Donald St Germain, Anne C Ferguson-Smith, and Arturo Hernandez

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Bone morphogenetic protein signaling in nephron progenitor cells., Leif Oxburgh, Aaron C. Brown, Sree Deepthi Muthukrishnan, and Jennifer L. Fetting

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Common features of microRNA target prediction tools., Sarah M Peterson, Jeffrey A Thompson, Melanie L Ufkin, Pradeep Sathyanarayana, Lucy Liaw, and Clare Bates Congdon

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Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation., Ashleigh Poole, Nicholas Knowland, Emily Cooper, Rebecca Cole, Hongchuan Wang, Lucas Booth, Doreen Kacer, Francesca Tarantini, Robert Friesel, and Igor Prudovsky

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Notch signal integration in the vasculature during remodeling., Bahman Rostama, Sarah M Peterson, Calvin P H Vary, and Lucy Liaw

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miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia., Melanie L Ufkin, Sarah Peterson, Xuehui Yang, Heather Driscoll, Christine Duarte, and Pradeep Sathyanarayana

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Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction., Ting Wang, Linden A Green, Samir K Gupta, Chul Kim, Liang Wang, Sharilyn Almodovar, Sonia C Flores, Igor A Prudovsky, Paul Jolicoeur, Ziyue Liu, and Matthias Clauss

Submissions from 2013

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The snail family gene snai3 is not essential for embryogenesis in mice., Cara K Bradley, Christine R Norton, Ying Chen, Xianghua Han, Carmen J Booth, Jeong Kyo Yoon, Luke T Krebs, and Thomas Gridley

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Role for compartmentalization in nephron progenitor differentiation., Aaron C Brown, Sree Deepthi Muthukrishnan, Justin A Guay, Derek C Adams, Dillon A Schafer, Jennifer L Fetting, and Leif Oxburgh

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Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis., Ying Chen and Thomas Gridley

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The SNAI1 and SNAI2 proteins occupy their own and each other's promoter during chondrogenesis., Ying Chen and Thomas Gridley

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Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src., Yan Gong, Xuehui Yang, Qing He, Lindsey Gower, Igor Prudovsky, Calvin P H Vary, Peter C Brooks, and Robert E Friesel

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Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis., Yuefeng Tang, Hao Bai, Sumithra Urs, Zack Wang, and Lucy Liaw

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Spry1 and Spry4 differentially regulate human aortic smooth muscle cell phenotype via Akt/FoxO/myocardin signaling., Xuehui Yang, Yan Gong, Yuefeng Tang, Hongfang Li, Qing He, Lindsey Gower, Lucy Liaw, and Robert E Friesel

Submissions from 2012

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Insulin-like growth factor binding protein-4 differentially inhibits growth factor-induced angiogenesis., Liangru W Contois, Desiree P Nugent, Jennifer M Caron, Alexandra Cretu, Eric Tweedie, Abebe Akalu, Leonard Liebes, Robert Friesel, Clifford Rosen, Calvin Vary, and Peter C Brooks

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The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice., Luke T Krebs, Cara K Bradley, Christine R Norton, Jingxia Xu, Kathleen F Oram, Christa Starling, Michael L Deftos, Michael J Bevan, and Thomas Gridley

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Cthrc1, a novel circulating hormone regulating metabolism., J Patrizia Stohn, Nicole G Perreault, Qiaozeng Wang, Lucy Liaw, and Volkhard Lindner

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Histone deacetylase activity selectively regulates notch-mediated smooth muscle differentiation in human vascular cells., Yuefeng Tang, Joshua M Boucher, and Lucy Liaw

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Mortality in rural locations after severe injuries from motor vehicle crashes., Lori L Travis, David E Clark, Amy E Haskins, and Joseph A Kilch

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Cellular signaling and biological functions of R-spondins., Jeong Kyo Yoon and Jin-Seon Lee

Submissions from 2011

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Isolation and culture of cells from the nephrogenic zone of the embryonic mouse kidney., Aaron C Brown, Ulrika Blank, Derek C Adams, Michele J Karolak, Jennifer L Fetting, Beth L Hill, and Leif Oxburgh

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BMP signaling in the nephron progenitor niche., Leif Oxburgh, Aaron C Brown, Jennifer Fetting, and Beth Hill

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Endoglin regulates cancer-stromal cell interactions in prostate tumors., Diana Romero, Christine O'Neill, Aleksandra Terzic, Liangru Contois, Kira Young, Barbara A Conley, Raymond C Bergan, Peter C Brooks, and Calvin P H Vary

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Mechanisms of TGF-β-induced differentiation in human vascular smooth muscle cells., Yuefeng Tang, Xuehui Yang, Robert E Friesel, Calvin P H Vary, and Lucy Liaw

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SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis., Berna Uygur and Wen-Shu Wu

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RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction., Deepak Venkatesh, Natalie Fredette, Bahman Rostama, Yuefeng Tang, Calvin P H Vary, Lucy Liaw, and Sumithra Urs

Submissions from 2010

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Follistatin-like 1 regulates renal IL-1β expression in cisplatin nephrotoxicity., Derek C Adams, Michele J Karolak, Barry W Larman, Lucy Liaw, James D Nolin, and Leif Oxburgh

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Two novel human NUMB isoforms provide a potential link between development and cancer., Aldona Karaczyn, Mahmud Bani-Yaghoub, Roger Tremblay, Chris Kubu, Rebecca Cowling, Tamara L Adams, Igor Prudovsky, Douglas Spicer, Robert Friesel, Calvin Vary, and Joseph M Verdi

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A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway., Nicholas Matluk, Jennifer A Rochira, Aldona Karaczyn, Tamara Adams, and Joseph M Verdi

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Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration., Diana Romero, Aleksandra Terzic, Barbara A Conley, Clarissa S Craft, Borko Jovanovic, Raymond C Bergan, and Calvin P H Vary

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The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells., Yuefeng Tang, Anne Harrington, Xuehui Yang, Robert E Friesel, and Lucy Liaw

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Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation., Yuefeng Tang, Sumithra Urs, Joshua Boucher, Tyler Bernaiche, Deepak Venkatesh, Douglas B Spicer, Calvin P H Vary, and Lucy Liaw