The Center for Molecular Medicine (CMM) was established in 1997 as a Center within Maine Medical Center Research Institute with the vision of performing cutting edge biomedical research to discover the molecular mechanisms of human disease, and to harness new knowledge in developmental biology and stem cells for regenerative medicine approaches. The investigators at CMM are committed to translating basic science discoveries to innovative approaches to diagnose and treat human disease.

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Submissions from 2024

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Effects of a Global Null Mutation on Murine PVAT and Cardiovascular Function, Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L. Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, Lucy Liaw, and Calvin Vary

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Magnitude of obesity alone does not alter the alveolar lipidome, William G. Tharp, Carolyn R. Morris, Yulica Santos-Ortega, and Calvin Vary

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Light-responsive adipose-hypothalamus axis controls metabolic regulation, Tadataka Tsuji, Vladimir Tolstikov, Yang Zhang, Tian Lian Huang, Henrique Camara, Meghan Halpin, Niven R. Narain, King-Wai Yau, and Matthew D. Lynes

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Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues, Zhaofei Wu, M Elena Martinez, and Arturo Hernandez

Submissions from 2023

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Purification of functional mouse skeletal muscle mitochondria using percoll density gradient centrifugation, Rea Victoria Anunciado-Koza, Anyonya R. Guntur, Calvin P. Vary, Carlos A. Gartner, Madeleine Nowak, and Robert A. Koza

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Navigating Uncertainty in Public Health Decisionmaking: The Role of a Value of Information Framework in Threat Agnostic Biosurveillance, Jalal Awan, Laura J. Faherty, and Henry H. Willis

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Post or Perish? Social Media Strategies for Disseminating Orthopedic Research, Evan G. Buettmann, Carolyn Chlebek, Carly A. Lockard, Sade W. Clayton, Karl J. Lewis, and Kelsey H. Collins

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Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth, Jennifer M. Caron, Xianghua Han, Christine W. Lary, Pradeep Sathyanarayana, Scot C. Remick, and Marc S. Ernstoff

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Effects of PTH on osteoblast bioenergetics in response to glucose, Victoria E. DeMambro, Li Tian, Vivin Karthik, Clifford J. Rosen, and Anyonya R. Guntur

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Role of resistance training in bone macro and micro damages in an estrogen absence animal model, Graziéle F. Deriggi-Pisani, Uliana S. Stotzer, Rita C. Marqueti, Maria F. Rodrigues, Bruna G. Biffe, Karina A. Silva, Victor Fabricio, Clifford J. Rosen, and Heloisa S. Sobreiro de Araujo

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Single-cell transcriptomics of bone marrow stromal cells in Diversity Outbred mice: a model for population-level scRNA-seq studies, Luke J. Dillard, Will T. Rosenow, Gina M. Calabrese, Larry D. Mesner, Basel M. Al-Barghouthi, Abdullah Abood, and Clifford J. Rosen

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Optogenetic activation of UCP1-dependent thermogenesis in brown adipocytes, Chad C. Doucette, Daniel C. Nguyen, Davide Barteselli, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, and Aaron C. Brown

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Irisin Enhances Mitochondrial Function in Osteoclast Progenitors during Differentiation, Eben Estell, Tsunagu Ichikawa, Paige Giffault, Lynda Bonewald, Bruce Spiegelman, and Clifford Rosen

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Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression, Jason V. Evans, Shankar Suman, Mounika Uttam Goruganthu, Elena E. Tchekneva, Shuxiao Guan, Rajeswara Rao Arasada, Anneliese Antonucci, Longzhu Piao, and Sergey Ryzhov

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Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling, Yi Fan, Ping Lyu, Ruiye Bi, Chen Cui, Ruoshi Xu, Clifford J. Rosen, Quan Yuan, and Chenchen Zhou

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Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signalin, Mariah Farrell, Heather Fairfield, Michelle Karam, Anastasia D'Amico, Connor S. Murphy, Carolyne Falank, Romanos Sklavenitis Pistofidi, Amanda Cao, Catherine R. Marinac, Julie A. Dragon, Lauren McGuinness, Carlos G. Gartner, and Reagan Di Iorio

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Thyroid Hormone Metabolism: A Historical Perspective, Valerie Anne Galton and Arturo Hernandez

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Epigenetic developmental programming and intergenerational effects of thyroid hormones, Arturo Hernandez, M Elena Martinez, Carolina Chaves, and Joao Anselmo

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Circulating neutrophil extracellular trap (NET)-forming 'rogue' neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19-, Victoria L. Herrera, Nicholas A. Bosch, Judith J. Lok, Mai Q. Nguyen, Kaitriona A. Lenae, Joanne T. deKay, Sergey V. Ryzhov, and David Seder

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A Novel ENU-Induced Mutation Causes Motor Deficits in Mice without Causing Peripheral Neuropathy, Timothy J. Hines, Janice Bailey, Hedi Liu, Anyonya R. Guntur, Kevin L. Seburn, Samia L. Pratt, Jonathan R. Funke, Lisa M. Tarantino, and Robert W. Burgess

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Thermoneutral housing does not rescue olanzapine-induced trabecular bone loss in C57BL/6J female mice, Audrie L. Langlais, Rebecca V. Mountain, Roni F. Kunst, Deborah Barlow, Karen L. Houseknecht, and Katherine J. Motyl

PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner, Hanghang Liu, Akane Wada, Isabella Le, Phuong T. Le, Andrew W. Lee, and Jun Zhou

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New Insights into Calorie Restriction Induced Bone Loss, Linyi Liu and Clifford J. Rosen

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The Multifaceted Roles of Bone Marrow Adipocytes in Bone and Hematopoietic Homeostasis, Ziru Li and Clifford J. Rosen

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A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 as a Negative Regulator of Glucose Uptake in Brown Adipocytes, Matthew D. Lynes, Qian Huang, Carolina Cora, Sheng-Chiang Su, Peng Yi, and Yu-Hua Tseng

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The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc, Vedavathi Madhu, Miriam Hernandez-Meadows, Paige K. Boneski, Yunping Qiu, Anyonya R. Guntur, and Irwin J. Kurland

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Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system, Maria Elena Martinez, Zhaofei Wu, and Arturo Hernandez

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Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells, Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F. Pansa, Sofía Carbajosa, Aaron C. Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P. Madauss, Gastón Soria, and Vanesa Gottifredi

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Bring the heat: Thermal stress, metabolic plasticity, and considerations for biomedical research, Katherine J. Motyl and Ormond A. MacDougald

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Social isolation through single housing negatively affects trabecular and cortical bone in adult male, but not female, C57BL/6J mice, Rebecca V. Mountain, Audrie L. Langlais, Dorothy Hu, Roland Baron, Christine W. Lary, and Katherine J. Motyl

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Toward Comprehensive Care for Long Covid, Janko Ž. Nikolich and Clifford J. Rosen

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Raising the Bar for Language Equity Health Care Research, Pilar Ortega, Mónica Vela, and Elizabeth A. Jacobs

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Peer Review in a General Medical Research Journal Before and During the COVID-19 Pandemic, Roy H. Perlis, Jacob Kendall-Taylor, Kamber Hart, Ishani Ganguli, Jesse A. Berlin, Steven M. Bradley, Sebastien Haneuse, Sharon K. Inouye, Elizabeth A. Jacobs, Arden Morris, Olugbenga Ogedegbe, Eli Perencevich, Lawrence N. Shulman, N Seth Trueger, Stephan D. Fihn, Frederick P. Rivara, and Annette Flanagin

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Antagonizing the Leptin Receptor in Obesity, Clifford J. Rosen

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Optimizing a therapeutic humanized follicle-stimulating hormone-blocking antibody formulation by protein thermal shift assay, Damini Sant, Satish Rojekar, Sakshi Gera, Anusha R. Pallapati, Judit Gimenez-Roig, Tan-Chun Kuo, and Clifford J. Rosen

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Editorial: Obesity and cancer: update on etiology, molecular biomarkers and biotargets, clinical strategies, and epidemiology, Eva Surmacz, Valentina Guarnotta, and Michaela Ruth Reagan

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Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis, Barbara Toomey, Sarah A. Mitrovic, Maia Lindner-Liaw, Ruth G. Leon Vazquez, Doreen Kacer, Sergey Ryzhov, and Igor Prudovsky

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Age-related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment, Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina DiPietro, Emma Paradie, Benjamin Tero, Anne Harrington, Larisa Ryzhova, Lucy Liaw, Peter C. Reifsnyder, David E. Harrison, and Kristy L. Townsend

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Notch Signaling Regulates Mouse Perivascular Adipose Tissue Function via Mitochondrial Pathways, Chenhao Yang, Xuehui Yang, Anne Harrington, Christian Potts, Abigail Kaija, Larisa Ryzhova, and Lucy Liaw

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Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells, Xuehui Yang, Chenhao Yang, Robert E. Friesel, and Lucy Liaw

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Bone circuitry and interorgan skeletal crosstalk, Mone Zaidi, Se-Min Kim, Mehr Mathew, Funda Korkmaz, Farhath Sultana, Sari Miyashita, Anisa Azatovna Gumerova, Tal Frolinger, Ofer Moldavski, Orly Barak, Anusha Pallapati, Satish Rojekar, John Caminis, Yelena Ginzburg, Vitaly Ryu, Terry F. Davies, Daria Lizneva, Clifford J. Rosen, and Tony Yuen

Submissions from 2022

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The effect of short-term high-caloric feeding and fasting on bone microarchitecture, Miriam A. Bredella, Pouneh K. Fazeli, Jenna Bourassa, Clifford J. Rosen, Mary L. Bouxsein, Anne Klibanski, and Karen K. Miller

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The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease, Carolyn Chlebek and Clifford J. Rosen

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Parathyroid Disorders Special Sections, Roberto Civitelli and Clifford J. Rosen

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The number of circulating CD26 expressing cells is decreased in critical COVID-19 illness, Joanne T. deKay, Teresa L. May, Jonathan Rud, David J. Gagnon, Douglas Sawyer, David B. Seder, Sergey Ryzhov, and Richard R. Riker

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Potential Mechanisms of Gut-Derived Extracellular Vesicle Participation in Glucose and Lipid Homeostasis, Tiange Feng, Weizhen Zhang, and Ziru Li

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FSH-blocking therapeutic for osteoporosis, Sakshi Gera, Tan-Chun Kuo, Anisa Azatovna Gumerova, Funda Korkmaz, Damini Sant, Victoria DeMambro, Karthyayani Sudha, Ashley Padilla, Geoffrey Prevot, Jazz Munitz, and Abraham Teunissen

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A critical bioenergetic switch is regulated by IGF2 during murine cartilage development, Judith M. Hollander, Lingyun Li, Miraj Rawal, Si Kun Wang, Yue Shu, Ming Zhang, Heber C. Nielsen, Clifford J. Rosen, and Li Zeng

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Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial, Kim M. Huffman, Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, Margery A. Connelly, Carl F. Pieper, Melissa Orenduff, Leanna M. Ross, Megan E. Ramaker, James L. Dorling, Clifford J. Rosen, Irina Shalaurova, James D. Otvos, Virginia B. Kraus, and William E. Kraus

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Thyroid hormone elicits intergenerational epigenetic effects on adult social behavior and fetal brain expression of autism susceptibility genes, Maria Elena Martinez, Julia Patrizia Stohn, Elizabeth M. Mutina, Rayne J. Whitten, and Arturo Hernandez

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DIO3 protects from thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities, M Elena Martinez, Ilka Pinz, Marilena Preda, Christine R. Norton, Thomas Gridley, and Arturo Hernandez

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Health care professional perspectives on discharging hospitalized patients with injection drug use-associated infections, Nichole Moore, Michael Kohut, Henry Stoddard, Debra Burris, Frank Chessa, Monica K. Sikka, Daniel Solomon, Colleen M. Kershaw, Ellen Eaton, Kathleen M. Fairfield, and Rebecca N. Hutchinson

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ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP, Janane F. Rahbani, Charlotte Scholtes, Damien M. Lagarde, Mohammed F. Hussain, Anna Roesler, Christien B. Dykstra, Jakub Bunk, Bozena Samborska, Shannon L. O'Brien, Emma Tripp, Alain Pacis, Anthony R. Angueira, Olivia S. Johansen, Jessica Cinkornpumin, Ishtiaque Hossain, Matthew D. Lynes, Yang Zhang, Andrew P. White, William A. Pastor, Maria Chondronikola, Labros Sidossis, Samuel Klein, and Anastasia Kralli

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Diversity in Clinical Trials - Next Steps, Clifford J. Rosen, Nakela L. Cook, and Consuelo H. Wilkins

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Vitamin D and Incident Fractures. Reply, Clifford J. Rosen and Steve Cummings

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Impact of multimodal dermatoscopy training on skin biopsies by primary care providers, Elizabeth V. Seiverling, Kathryn Stevens, Gregory Dorr, Madeline A. Prentiss, Henry Stoddard, Laura Houk, Peg Cyr, and Hadjh Ahrns

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Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development, John P. Sundberg, Hannah Galantino-Homer, Heather Fairfield, Patricia F. Ward-Bailey, Belinda S. Harris, Melissa Berry, C Herbert Pratt, Nicholas E. Gott, Lesley S. Bechtold, Pauline R. Kaplan, Blythe P. Durbin-Johnson, David M. Rocke, and Robert H. Rice

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Quantification of Lipid Area within Thermogenic Mouse Perivascular Adipose Tissue Using Standardized Image Analysis in FIJI, Benjamin W. Tero, Bethany Fortier, Ashley N. Soucy, Ginger Paquette, and Lucy Liaw

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Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration, Robert J. Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R. Guntur, Jennifer Simkin, and Mimi C. Sammarco

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Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure, Kristy L. Townsend, Eleanor Pritchard, Jeannine M. Coburn, Young Mi Kwon, Magdalena Blaszkiewicz, Matthew D. Lynes, David L. Kaplan, and Yu-Hua Tseng

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Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation, Zhaofei Wu, M Elena Martinez, Victoria DeMambro, Marie Francois, and Arturo Hernandez

Submissions from 2021

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FOXD1 regulates cell division in clear cell renal cell carcinoma, Kyle H. Bond, Jennifer L. Fetting, Christine W. Lary, Ivette F. Emery, and Leif Oxburgh

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DEspR neutrophils are associated with critical illness in COVID-19, Joanne T. deKay, Ivette F. Emery, Jonathan Rud, Ashley Eldridge, Christine Lord, David J. Gagnon, and Teresa L. May

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Notch1 and Notch2 collaboratively maintain radial glial cells in mouse neurogenesis, Shun Mase, Atsunori Shitamukai, Quan Wu, Mitsuru Morimoto, Thomas Gridley, and Fumio Matsuzaki

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Protective role of ErbB3 signaling in myeloid cells during adaptation to cardiac pressure overload, Haifeng Yin, Amanda J. Favreau-Lessard, Joanne T. deKay, Yodit R. Herrmann, Michael P. Robich, Robert A. Koza, Igor Prudovsky, Douglas B. Sawyer, and Sergey Ryzhov

Submissions from 2020

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How Dietary Deficiency Studies Have Illuminated the Many Roles of Vitamin A During Development and Postnatal Life, Mary Ann Asson-Batres

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Notch Dosage Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice, Christopher A. Blackwood, Alessandro Bailetti, Sayan Nandi, Thomas Gridley, and Jean M. Hébert

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Stromal SNAI2 is required for ERBB2 breast cancer progression., Adrián Blanco-Gómez, Lourdes Hontecillas-Prieto, Roberto Corchado-Cobos, Natalia García-Sancha, Nélida Salvador, Andrés Castellanos-Martín, María Del Mar Sáez-Freire, Marina Mendiburu-Eliçabe, Diego Alonso-López, Javier De Las Rivas, Mar Lorente, Ana García-Casas, Sofía Del Carmen, María Del Mar Abad-Hernández, Juan Jesús Cruz-Hernández, César Augusto Rodríguez-Sánchez, Juncal Claros-Ampuero, Begoña García-Cenador, Javier García-Criado, Akira Orimo, Thomas Gridley, Jesús Pérez-Losada, and Sonia Castillo-Lluva

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High ErbB3 activating activity in human blood is not due to circulating neuregulin-1 beta, Emmanuel Boateng, Joanne T. deKay, Sarah M. Peterson, Jacob Boles, Nathan Pinnette, Mary W. Sorcher, Michael P. Robich, Douglas B. Sawyer, and Sergey Ryzhov

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Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation., Joshua M Boucher, Larisa Ryzhova, Anne Harrington, Jessica Davis-Knowlton, Jacqueline E Turner, Emily Cooper, David Maridas, Sergey Ryzhov, Clifford J Rosen, Calvin P H Vary, and Lucy Liaw

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Precision and Functional Genomics., Steve D M Brown and Joseph H Nadeau

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Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging, Rosaly Correa-de-Araujo, Odessa Addison, Iva Miljkovic, Bret H. Goodpaster, Bryan C. Bergman, Richard V. Clark, Joanne W. Elena, Karyn A. Esser, Luigi Ferrucci, Michael O. Harris-Love, Steve B. Kritchevsky, Amanda Lorbergs, John A. Shepherd, Gerald I. Shulman, and Clifford J. Rosen

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Common Mechanistic Pathways in Cancer and Heart Failure., Rudolf A de Boer, Jean-Sébastien Hulot, Carlo Gabriele Tocchetti, Joseph Pierre Aboumsallem, Pietro Ameri, Stefan D Anker, Johann Bauersachs, Edoardo Bertero, Andrew A J Coats, Jelena Čelutkienė, Ovidiu Chioncel, Pierre Dodion, Thomas Eschenhagen, Dimitrios Farmakis, Antoni Bayes-Genis, Dirk Jäger, Ewa A Jankowska, Richard N Kitsis, Suma H Konety, James Larkin, Lorenz Lehmann, Daniel J Lenihan, Christoph Maack, Javid Moslehi, Oliver J Müller, Patrycja Nowak-Sliwinska, Massimo Francesco Piepoli, Piotr Ponikowski, Radek Pudil, Peter P Rainer, Frank Ruschitzka, Douglas Sawyer, Petar M Seferovic, Thomas Suter, Thomas Thum, Peter van der Meer, Linda W Van Laake, Stephan von Haehling, Stephane Heymans, Alexander R Lyon, and Johannes Backs

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Tuberculosis and foreign-born populations in the United States: A mixed methods pilot study of media reporting and political identification, Angel N. Desai, Shravanthi M. Seshasayee, Maimuna S. Majumder, Britta Lassmann, Lawrence C. Madoff, Emily L. Cohn, and John S. Brownstein

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Involvement of early embryonic miR-409-3p in the establishment of anxiety levels in female mice, David A. Dickson, Patrizia Stohn, Lorena Saavedra Rodriguez, Arturo Hernandez, Anne Harrington, Lucy Liaw, and Larry A. Feig

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Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification., Heather Fairfield, Samantha Costa, Victoria DeMambro, Celine Schott, Janaina Da Silva Martins, Mathieu Ferron, Calvin Vary, and Michaela R Reagan

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Deletion of α-Synuclein in Prrx1-positive cells causes partial loss of function in the central nervous system (CNS) but does not affect ovariectomy induced bone loss, Carolina A. Figueroa, Pratima Bajgain, J Patrizia Stohn, Arturo Hernandez, Daniel J. Brooks, Karen L. Houseknecht, and Clifford J. Rosen

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Parkinson's disease and osteoporosis: basic and clinical implications, Carolina A. Figueroa and Clifford J. Rosen

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The Intrinsic Activity of Thyroxine is Critical for Survival and Growth and Regulates Gene expression in Neonatal Liver., Valerie Anne Galton, M Elena Martinez, Julie A Dragon, Donald L St Germain, and Arturo Hernandez

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Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis., Charlotte Girondel, Kim Lévesque, Marie-Josée Langlois, Sarah Pasquin, Marc K Saba-El-Leil, Nathalie Rivard, Robert Friesel, Marc J Servant, Jean-François Gauchat, Sylvie Lesage, and Sylvain Meloche

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Cryptic collagen elements as signaling hubs in the regulation of tumor growth and metastasis, XiangHua Han, Jennifer M. Caron, and Peter C. Brooks

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Phospho-proteomic discovery of novel signal transducers including thioredoxin-interacting protein as mediators of erythropoietin-dependent human erythropoiesis., Matthew A Held, Emily Greenfest-Allen, Edward Jachimowicz, Christian J Stoeckert, Matthew P Stokes, Antony W Wood, and Don M Wojchowski

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Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling., Matthew A Held, Emily Greenfest-Allen, Su Su, Christian J Stoeckert, Matthew P Stokes, and Don M Wojchowski

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Thyroid hormone action in the developing testis: intergenerational epigenetics., Arturo Hernandez and Maria Elena Martinez

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Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice, Yong-Ri Jin, Xiang Hua Han, Katsuhiko Nishimori, Dan Ben-Avraham, Youn Jeong Oh, Jae-Won Shim, and Jeong Kyo Yoon

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Functional study of CTHRC1 on skeletal muscle regeneration and skeletal muscle stem cells, Yong-Ri Jin, Qiaozeng Wang, Igor Prudovsky, and Volkhard Lindner

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MicroRNA199b regulates mouse hematopoietic stem cells maintenance, Aldona A. Karaczyn, Edward Jachimowicz, Jaspreet S. Kohli, and Pradeep Sathyanarayana

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Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models Of Hereditary Hemorrhagic Telangiectasia., Yong Hwan Kim, Nhung Vu Phuong, Se-Woon Choe, Chang Jin Jeon, Helen M Arthur, Calvin Ph Vary, Young-Jae Lee, and Suk P Oh

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Ten simple rules for women principal investigators during a pandemic., Pamela K Kreeger, Amy Brock, Holly C Gibbs, K Jane Grande-Allen, Alice H Huang, Kristyn S Masters, Padmini Rangamani, Michaela R. Reagan, and Shannon L Servoss

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Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids, Ashwani Kumar Gupta, Prasenjit Sarkar, Jason A. Wertheim, Xinchao Pan, Thomas J. Carroll, and Leif Oxburgh

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Association of Beta Blocker Use With Bone Mineral Density in the Framingham Osteoporosis Study: A Cross-Sectional Study, Christine W. Lary, Alexandra C. Hinton, Kathleen T. Nevola, Theresa I. Shireman, Katherine J. Motyl, Karen L. Houseknecht, F Lee Lucas, Sarah Hallen, Andrew R. Zullo, Sarah D. Berry, and Douglas P. Kiel

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miRNA Mechanisms Underlying the Association of Beta Blocker Use and Bone Mineral Density., Kathleen T Nevola, Douglas P Kiel, Andrew R Zullo, Stefan Weiss, Georg Homuth, Ines Foessl, Barbara Obermayer-Pietsch, Katherine J Motyl, and Christine W Lary

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Observed emotional reactivity in response to frustration tasks in psychiatrically hospitalized youth with autism spectrum disorder, Jessie B. Northrup, Matthew Goodwin, Joshua Montrenes, Jessica Vezzoli, Josh Golt, Christine B. Peura, Matthew Siegel, and Carla Mazefsky

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Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach, Emma V. Preston, Thomas F. Webster, Birgit Claus Henn, Michael D. McClean, Chris Gennings, Emily Oken, Sheryl L. Rifas-Shiman, Elizabeth N. Pearce, Antonia M. Calafat, Abby F. Fleisch, and Sharon K. Sagiv

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Critical Assessment of In Vitro and In Vivo Models to Study Marrow Adipose Tissue., Michaela R Reagan

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Lipids in the Bone Marrow: An Evolving Perspective., Elizabeth Rendina-Ruedy and Clifford J Rosen

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Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling., Jay Prakash Sah, Nguyen Thi Thu Hao, Xianghua Han, Trinh Thi Tuyet Tran, Sarah McCarthy, Younjeong Oh, and Jeong Kyo Yoon

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Infective Endocarditis During the Infectious Diseases and Substance Use Disorder Syndemic: A Six-Year Case Series, N P. Sankar, K Thakarar, and Kristina E. Rokas

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PHOSPHO1 is a skeletal regulator of insulin resistance and obesity., Karla J Suchacki, Nicholas M Morton, Calvin Vary, Carmen Huesa, Manisha C Yadav, Benjamin J Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E Barrios-Llerena, Anyonya R Guntur, Zohreh Khavandgar, William P Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed, Clifford J Rosen, Vicky E MacRae, Jose Luis Millán, and Colin Farquharson

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BNIP3 mediated Mitophagy is essential for osteoblast differentiation, Li Tian, Victoria Van Berlo, Vivin Karthik, Joshua P. Passarelli, and Anyonya R. Guntur