The Center for Molecular Medicine (CMM) was established in 1997 as a Center within Maine Medical Center Research Institute with the vision of performing cutting edge biomedical research to discover the molecular mechanisms of human disease, and to harness new knowledge in developmental biology and stem cells for regenerative medicine approaches. The investigators at CMM are committed to translating basic science discoveries to innovative approaches to diagnose and treat human disease.

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Submissions from 2020

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Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation., Joshua M Boucher, Larisa Ryzhova, Anne Harrington, Jessica Davis-Knowlton, Jacqueline E Turner, Emily Cooper, David Maridas, Sergey Ryzhov, Clifford J Rosen, Calvin P H Vary, and Lucy Liaw

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Precision and Functional Genomics., Steve D M Brown and Joseph H Nadeau

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Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging, Rosaly Correa-de-Araujo, Odessa Addison, Iva Miljkovic, Bret H. Goodpaster, Bryan C. Bergman, Richard V. Clark, Joanne W. Elena, Karyn A. Esser, Luigi Ferrucci, Michael O. Harris-Love, Steve B. Kritchevsky, Amanda Lorbergs, John A. Shepherd, Gerald I. Shulman, and Clifford J. Rosen

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Common Mechanistic Pathways in Cancer and Heart Failure., Rudolf A de Boer, Jean-Sébastien Hulot, Carlo Gabriele Tocchetti, Joseph Pierre Aboumsallem, Pietro Ameri, Stefan D Anker, Johann Bauersachs, Edoardo Bertero, Andrew A J Coats, Jelena Čelutkienė, Ovidiu Chioncel, Pierre Dodion, Thomas Eschenhagen, Dimitrios Farmakis, Antoni Bayes-Genis, Dirk Jäger, Ewa A Jankowska, Richard N Kitsis, Suma H Konety, James Larkin, Lorenz Lehmann, Daniel J Lenihan, Christoph Maack, Javid Moslehi, Oliver J Müller, Patrycja Nowak-Sliwinska, Massimo Francesco Piepoli, Piotr Ponikowski, Radek Pudil, Peter P Rainer, Frank Ruschitzka, Douglas Sawyer, Petar M Seferovic, Thomas Suter, Thomas Thum, Peter van der Meer, Linda W Van Laake, Stephan von Haehling, Stephane Heymans, Alexander R Lyon, and Johannes Backs

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Tuberculosis and foreign-born populations in the United States: A mixed methods pilot study of media reporting and political identification, Angel N. Desai, Shravanthi M. Seshasayee, Maimuna S. Majumder, Britta Lassmann, Lawrence C. Madoff, Emily L. Cohn, and John S. Brownstein

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Involvement of early embryonic miR-409-3p in the establishment of anxiety levels in female mice, David A. Dickson, Patrizia Stohn, Lorena Saavedra Rodriguez, Arturo Hernandez, Anne Harrington, Lucy Liaw, and Larry A. Feig

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Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification., Heather Fairfield, Samantha Costa, Victoria DeMambro, Celine Schott, Janaina Da Silva Martins, Mathieu Ferron, Calvin Vary, and Michaela R Reagan

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Deletion of α-Synuclein in Prrx1-positive cells causes partial loss of function in the central nervous system (CNS) but does not affect ovariectomy induced bone loss, Carolina A. Figueroa, Pratima Bajgain, J Patrizia Stohn, Arturo Hernandez, Daniel J. Brooks, Karen L. Houseknecht, and Clifford J. Rosen

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Parkinson's disease and osteoporosis: basic and clinical implications, Carolina A. Figueroa and Clifford J. Rosen

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The Intrinsic Activity of Thyroxine is Critical for Survival and Growth and Regulates Gene expression in Neonatal Liver., Valerie Anne Galton, M Elena Martinez, Julie A Dragon, Donald L St Germain, and Arturo Hernandez

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Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis., Charlotte Girondel, Kim Lévesque, Marie-Josée Langlois, Sarah Pasquin, Marc K Saba-El-Leil, Nathalie Rivard, Robert Friesel, Marc J Servant, Jean-François Gauchat, Sylvie Lesage, and Sylvain Meloche

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Cryptic collagen elements as signaling hubs in the regulation of tumor growth and metastasis, XiangHua Han, Jennifer M. Caron, and Peter C. Brooks

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Phospho-proteomic discovery of novel signal transducers including thioredoxin-interacting protein as mediators of erythropoietin-dependent human erythropoiesis., Matthew A Held, Emily Greenfest-Allen, Edward Jachimowicz, Christian J Stoeckert, Matthew P Stokes, Antony W Wood, and Don M Wojchowski

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Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling., Matthew A Held, Emily Greenfest-Allen, Su Su, Christian J Stoeckert, Matthew P Stokes, and Don M Wojchowski

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Thyroid hormone action in the developing testis: intergenerational epigenetics., Arturo Hernandez and Maria Elena Martinez

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Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice, Yong-Ri Jin, Xiang Hua Han, Katsuhiko Nishimori, Dan Ben-Avraham, Youn Jeong Oh, Jae-Won Shim, and Jeong Kyo Yoon

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Functional study of CTHRC1 on skeletal muscle regeneration and skeletal muscle stem cells, Yong-Ri Jin, Qiaozeng Wang, Igor Prudovsky, and Volkhard Lindner

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MicroRNA199b regulates mouse hematopoietic stem cells maintenance, Aldona A. Karaczyn, Edward Jachimowicz, Jaspreet S. Kohli, and Pradeep Sathyanarayana

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Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models Of Hereditary Hemorrhagic Telangiectasia., Yong Hwan Kim, Nhung Vu Phuong, Se-Woon Choe, Chang Jin Jeon, Helen M Arthur, Calvin Ph Vary, Young-Jae Lee, and Suk P Oh

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Ten simple rules for women principal investigators during a pandemic., Pamela K Kreeger, Amy Brock, Holly C Gibbs, K Jane Grande-Allen, Alice H Huang, Kristyn S Masters, Padmini Rangamani, Michaela R. Reagan, and Shannon L Servoss

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Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids, Ashwani Kumar Gupta, Prasenjit Sarkar, Jason A. Wertheim, Xinchao Pan, Thomas J. Carroll, and Leif Oxburgh

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Association of Beta Blocker Use With Bone Mineral Density in the Framingham Osteoporosis Study: A Cross-Sectional Study, Christine W. Lary, Alexandra C. Hinton, Kathleen T. Nevola, Theresa I. Shireman, Katherine J. Motyl, Karen L. Houseknecht, F Lee Lucas, Sarah Hallen, Andrew R. Zullo, Sarah D. Berry, and Douglas P. Kiel

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miRNA Mechanisms Underlying the Association of Beta Blocker Use and Bone Mineral Density., Kathleen T Nevola, Douglas P Kiel, Andrew R Zullo, Stefan Weiss, Georg Homuth, Ines Foessl, Barbara Obermayer-Pietsch, Katherine J Motyl, and Christine W Lary

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Observed emotional reactivity in response to frustration tasks in psychiatrically hospitalized youth with autism spectrum disorder, Jessie B. Northrup, Matthew Goodwin, Joshua Montrenes, Jessica Vezzoli, Josh Golt, Christine B. Peura, Matthew Siegel, and Carla Mazefsky

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Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach, Emma V. Preston, Thomas F. Webster, Birgit Claus Henn, Michael D. McClean, Chris Gennings, Emily Oken, Sheryl L. Rifas-Shiman, Elizabeth N. Pearce, Antonia M. Calafat, Abby F. Fleisch, and Sharon K. Sagiv

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Critical Assessment of In Vitro and In Vivo Models to Study Marrow Adipose Tissue., Michaela R Reagan

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Lipids in the Bone Marrow: An Evolving Perspective., Elizabeth Rendina-Ruedy and Clifford J Rosen

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Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling., Jay Prakash Sah, Nguyen Thi Thu Hao, Xianghua Han, Trinh Thi Tuyet Tran, Sarah McCarthy, Younjeong Oh, and Jeong Kyo Yoon

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Infective Endocarditis During the Infectious Diseases and Substance Use Disorder Syndemic: A Six-Year Case Series, N P. Sankar, K Thakarar, and Kristina E. Rokas

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PHOSPHO1 is a skeletal regulator of insulin resistance and obesity., Karla J Suchacki, Nicholas M Morton, Calvin Vary, Carmen Huesa, Manisha C Yadav, Benjamin J Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E Barrios-Llerena, Anyonya R Guntur, Zohreh Khavandgar, William P Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed, Clifford J Rosen, Vicky E MacRae, Jose Luis Millán, and Colin Farquharson

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BNIP3 mediated Mitophagy is essential for osteoblast differentiation, Li Tian, Victoria Van Berlo, Vivin Karthik, Joshua P. Passarelli, and Anyonya R. Guntur

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Loss of Spry1 in vascular smooth muscle cells promotes hypercholesterolemiainduced VSMC phenotypic transitions and regulates atherogenesis, Xuehui Yang, Shivangi Pande, and Robert Friesel

Submissions from 2019

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Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling., Anna-Marei Böhm, Naomi Dirckx, Robert J Tower, Nicolas Peredo, Sebastiaan Vanuytven, Koen Theunis, Elena Nefyodova, Ruben Cardoen, Volkhard Lindner, Thierry Voet, Matthias Van Hul, and Christa Maes

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Long-Term Culture of Nephron Progenitor Cells Ex Vivo., Aaron C Brown, Ashwani K Gupta, and Leif Oxburgh

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Sirtuin 3 deficiency does not impede digit regeneration in mice., Emily Busse, Jennifer Simkin, Luis Marrero, Kennon Stewart, Regina Brunauer, Ken Muneoka, Anyonya Guntur, Michelle Lacey, and Mimi Sammarco

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Correction: Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1, Subhasis Das, Rakesh Sathish Nair, Rajakishore Mishra, Gautam Sondarva, Navin Viswakarma, Hazem Abdelkarim, Vadim Gaponenko, Pradeep Sathyanarayana, Basabi Rana, and Ajay Rana

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Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling., Jessica Davis-Knowlton, Jacqueline E Turner, Anna Turner, Sydney Damian-Loring, Nicholas Hagler, Terry Henderson, Ivette F Emery, Kyle Bond, Christine W Duarte, Calvin P H Vary, Jens Eldrup-Jorgensen, and Lucy Liaw

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Kidney-in-a-lymph node: a novel organogenesis assay to model human renal development and test nephron progenitor cell fates., Maria Giovanna Francipane, Bing Han, Leif Oxburgh, Sunder Sims-Lucas, Zhongwei Li, and Eric Lagasse

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Isolation and identification of endogenous RFamide-related peptides 1 and 3 in the mouse hypothalamus., Emilia Gospodarska, Leslie P Kozak, and Julia Jaroslawska

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Scaffolding kidney organoids on silk., Ashwani Kumar Gupta, Jeannine M Coburn, Jessica Davis-Knowlton, Erica Kimmerling, David L Kaplan, and Leif Oxburgh

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In Vitro 3D Cultures to Reproduce the Bone Marrow Niche., Justin Ham, Lauren Lever, Maura Fox, and Michaela R Reagan

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Thyroid hormone and alcoholic fatty liver: the developmental input., Arturo Hernandez

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Resistance to visceral obesity is associated with increased locomotion in mice expressing an endothelial cell-specific fibroblast growth factor 1 transgene., Tyler Keeley, Aleksandr Kirov, Woon Yuen Koh, Victoria Demambro, Ivy Bergquist, Jessica Cotter, Peter Caradonna, Matthew E Siviski, Bradley Best, Terry Henderson, Clifford J Rosen, Lucy Liaw, Igor Prudovsky, and Deena J Small

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A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice., Phuong T Le, Sheila A Bornstein, Katherine J Motyl, Li Tian, Jeremy J Stubblefield, Hee-Kyung Hong, Joseph S Takahashi, Carla B Green, Clifford J Rosen, and Anyonya R Guntur

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Spermatogonial Type 3 Deiodinase Regulates Thyroid Hormone Target Genes in Developing Testicular Somatic Cells., M Elena Martinez, Christine W Lary, Aldona A Karaczyn, Michael D Griswold, and Arturo Hernandez

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Multiple Myeloma and Fatty Acid Metabolism., Majdi Masarwi, Abigail DeSchiffart, Justin Ham, and Michaela R Reagan

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The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice., Meghan May, Megan Beauchemin, Calvin Vary, Deborah Barlow, and Karen L Houseknecht

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Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain., Sébastien Sannajust, Ian Imbert, Victoria Eaton, Terry Henderson, Lucy Liaw, Meghan May, Mary F Barbe, and Tamara King

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Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells., Michaela Tencerova, Elizabeth Rendina-Ruedy, Ditte Neess, Nils Færgeman, Florence Figeac, Dalia Ali, Morten Danielsen, Anders Haakonsson, Clifford J Rosen, and Moustapha Kassem

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Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells., Berna Uygur, Evgenia Leikina, Kamran Melikov, Rafael Villasmil, Santosh K Verma, Calvin P H Vary, and Leonid V Chernomordik

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Macrophage colony-stimulating factor pretreatment of bone marrow progenitor cells regulates osteoclast differentiation based upon the stage of myeloid development., Xuehui Yang, Shivangi Pande, Cameron Scott, and Robert Friesel

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The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage., Qian Zhang, Ryan C Riddle, Qian Yang, Clifford R Rosen, Denis C Guttridge, Naomi Dirckx, Marie-Claude Faugere, Charles R Farber, and Thomas L Clemens

Submissions from 2018

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Rab27a Regulates Human Perivascular Adipose Progenitor Cell Differentiation., Joshua M Boucher, Michael Robich, S Spencer Scott, Xuehui Yang, Larisa Ryzhova, Jacqueline E Turner, Ilka Pinz, and Lucy Liaw

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The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism., Jennifer M Caron, XiangHua Han, Liangru Contois, Calvin P H Vary, and Peter C Brooks

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High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice., Adriana Lelis Carvalho, Victoria E DeMambro, Anyonya R Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco José Albuquerque de Paula, and Katherine J Motyl

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The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological Function., Arturo Hernandez and J Patrizia Stohn

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Inactivation of MAP3K7 in FOXD1-expressing cells results in loss of mesangial PDGFRΒ and juvenile kidney scarring., Michele J Karolak, Justin A Guay, and Leif Oxburgh

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Effects of endogenous serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic dysfunction., Jennifer Miao, Shi Huang, Yan Ru Su, Carrie A Lenneman, Meera Wright, Frank E Harrell, Douglas B Sawyer, and Daniel J Lenihan

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Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney., Sree Deepthi Muthukrishnan, Sergey Ryzhov, Michele Karolak, and Leif Oxburgh

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Mesoderm-specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy., Igor Prudovsky, Rea P Anunciado-Koza, Chester G Jacobs, Doreen Kacer, Matthew E Siviski, and Robert A Koza

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Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Lepr, Peter C Reifsnyder, Sergey Ryzhov, Kevin Flurkey, Rea P Anunciado-Koza, Ian Mills, David E Harrison, and Robert A Koza

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A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome., Su Su, Anyonya R Guntur, Daniel C Nguyen, Shameem S Fakory, Chad C Doucette, Cassandra Leech, Humphrey Lotana, Matthew Kelley, Jaspreet Kohli, Julieta Martino, Sunder Sims-Lucas, Lucy Liaw, Calvin Vary, Clifford J Rosen, and Aaron C Brown

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The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species., Anne H van der Spek, Kin Ki Jim, Aldona Karaczyn, Hermina C van Beeren, Mariëtte T Ackermans, Veerle M Darras, Christina M J E Vandenbroucke-Grauls, Arturo Hernandez, Matthijs C Brouwer, Eric Fliers, Diederik van de Beek, and Anita Boelen

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Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function., Anne H van der Spek, Olga V Surovtseva, Kin Ki Jim, Adri van Oudenaren, Matthijs C Brouwer, Christina M J E Vandenbroucke-Grauls, Pieter J M Leenen, Diederik van de Beek, Arturo Hernandez, Eric Fliers, and Anita Boelen

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Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits., Xuehui Yang, Yan Gong, Qing He, Jonathan D Licht, Lucy Liaw, and Robert E Friesel

Submissions from 2017

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Effects of treadmill exercise on advanced osteoarthritis pain in rats., Joshua Allen, Ian Imbert, Joshua Havelin, Terry Henderson, Glenn Stevenson, Lucy Liaw, and Tamara King

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Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest)., Rea P Anunciado-Koza, Justin Manuel, Randall L Mynatt, Jingying Zhang, Leslie P Kozak, and Robert A Koza

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Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis., Jim Cormier, Katherine Cone, Janell Lanpher, Abigail Kinens, Terry Henderson, Lucy Liaw, Edward J Bilsky, Tamara King, Clifford J Rosen, and Glenn W Stevenson

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Governing roles for Trib3 pseudokinase during stress erythropoiesis., Arvind Dev, Ruth Asch, Edward Jachimowicz, Nicole Rainville, Ashley Johnson, Emily Greenfest-Allen, and Don M Wojchowski

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Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1., Yong-Ri Jin, J Patrizia Stohn, Qiaozeng Wang, Kenichi Nagano, Roland Baron, Mary L Bouxsein, Clifford J Rosen, Vyacheslav A Adarichev, and Volkhard Lindner

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Human NUMB6 induces epithelial-mesenchymal transition and enhances breast cancer cells migration and Invasion., Aldona A. Karaczyn, Tamara L Adams, Robert Y S Cheng, Nicholas N Matluk, and Joseph M Verdi

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Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration., Pan Li, Aldona A Karaczyn, Rose McGlauflin, Amanda J Favreau-Lessard, Edward Jachimowicz, Calvin P Vary, Kailin Xu, Don M Wojchowski, and Pradeep Sathyanarayana

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A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice., Katherine J Motyl, Megan Beauchemin, Deborah Barlow, Phuong T Le, Kenichi Nagano, Annika Treyball, Anisha Contractor, Roland Baron, Clifford J Rosen, and Karen L Houseknecht

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Energy metabolism of bone., Katherine J Motyl, Anyonya R Guntur, Adriana Lelis Carvalho, and Clifford J Rosen

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(Re)Building a Kidney., Leif Oxburgh, Thomas J Carroll, Ondine Cleaver, Daniel R Gossett, Deborah K Hoshizaki, Jeffrey A Hubbell, Benjamin D Humphreys, Sanjay Jain, Jan Jensen, David L Kaplan, Carl Kesselman, Christian J Ketchum, Melissa H Little, Andrew P McMahon, Stuart J Shankland, Jason R Spence, M Todd Valerius, Jason A Wertheim, Oliver Wessely, Ying Zheng, and Iain A Drummond

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Growth factor regulation in the nephrogenic zone of the developing kidney., Leif Oxburgh, Sree Deepthi Muthukrishnan, and Aaron Brown

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New insights into fuel choices of nephron progenitor cells., Leif Oxburgh and Clifford J Rosen

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Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson

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Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity., Zhaofei Wu, M Elena Martinez, Donald L St Germain, and Arturo Hernandez

Submissions from 2016

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Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer., Maria Raffaella Ambrosio, Claudia Di Serio, Giovanna Danza, Bruno Jim Rocca, Alessandro Ginori, Igor Prudovsky, Niccolò Marchionni, Maria Teresa Del Vecchio, and Francesca Tarantini

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Identification of an endogenously generated cryptic collagen epitope (XL313) that may selectively regulate angiogenesis by an integrin Yes-associated protein (YAP) mechano-transduction pathway, Jacquelyn J Ames, Liangru Contois, Jennifer M Caron, Eric Tweedie, Xuehui Yang, Robert Friesel, Calvin Vary, and Peter C Brooks

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Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model., Jacquelyn J Ames, Terry Henderson, Lucy Liaw, and Peter C Brooks

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Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet., Rea P Anunciado-Koza, David C Higgins, and Robert A Koza

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Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat., Rea P Anunciado-Koza, Justin Manuel, and Robert A Koza

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Stromal β-catenin overexpression contributes to the pathogenesis of renal dysplasia., Felix J Boivin, Sanjay Sarin, Pari Dabas, Michele Karolak, Leif Oxburgh, and Darren Bridgewater

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Inhibition of ovarian tumor growth by targeting the HU177 cryptic collagen epitope., Jennifer M M. Caron, Jacquelyn J. Ames, Liangru Contois, Leonard Liebes, Robert Friesel, Franco Muggia, Calvin PH Vary, Leif Oxburgh, and Peter C Brooks

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miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implications., Amanda J Favreau, Rose E McGlauflin, Christine W Duarte, and Pradeep Sathyanarayana

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Novel biological therapies targeting heart failure: myocardial rejuvenation., Amanda J. Favreau-Lessard, Sergey Ryzhov, and Douglas B. Sawyer

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Twenty Years in Maine: Integrating Insights from Developmental Biology into Translational Medicine in a Small State., Thomas Gridley

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Aberrant expression of Twist1 in diseased articular cartilage and a potential role in the modulation of osteoarthritis severity., Rosa M Guzzo, Farhang Alaee, David Paglia, Jason D Gibson, Douglas Spicer, and Hicham Drissi

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Sef Regulates Epithelial-Mesenchymal Transition in Breast Cancer Cells., Qing He, Yan Gong, Lindsey Gower, Xuehui Yang, and Robert E Friesel

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Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype., Qing He, Hongyu Jing, Lucy Liaw, Lindsey Gower, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Notch signal reception is required in vascular smooth muscle cells for ductus arteriosus closure., Luke T Krebs, Christine R Norton, and Thomas Gridley

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Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues., Lucy Liaw, Igor Prudovsky, Robert A Koza, Rea V Anunciado-Koza, Matthew E Siviski, Volkhard Lindner, Robert E Friesel, Clifford J Rosen, Paul R S Baker, Brigitte Simons, and Calvin P H Vary

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Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14., Maria Elena Martinez, David F. Cox, Brian P. Youth, and Arturo Hernandez

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The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis., M Elena Martinez, Aldona Karaczyn, J Patrizia Stohn, William T Donnelly, Walburga Croteau, Robin P Peeters, Valerie A Galton, Douglas Forrest, Donald St Germain, and Arturo Hernandez

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Development: Unique genetic determinants of human kidney development., Leif Oxburgh

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The bioengineered kidney: science or science fiction?, Leif Oxburgh and Thomas J Carroll