The Center for Molecular Medicine (CMM) was established in 1997 as a Center within Maine Medical Center Research Institute with the vision of performing cutting edge biomedical research to discover the molecular mechanisms of human disease, and to harness new knowledge in developmental biology and stem cells for regenerative medicine approaches. The investigators at CMM are committed to translating basic science discoveries to innovative approaches to diagnose and treat human disease.

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Submissions from 2024

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Long Covid and Impaired Cognition - More Evidence and More Work to Do, Ziyad Al-Aly and Clifford J. Rosen

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Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function, Gertrude Arthur, Audrey Poupeau, Katherine Biel, Jeffrey L. Osborn, Ming Gong, Terry D. Hinds, Volkhard Lindner, and Analia S. Loria

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Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance, Nadejda Bozadjieva-Kramer, Jae Hoon Shin, Ziru Li, Alan C. Rupp, and Nicole Miller

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Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice, Manuel Chiusa, Youngmin A. Lee, Ming-Zhi Zhang, Raymond C. Harris, Taylor Sherrill, Volkhard Lindner, Craig R. Brooks, Gang Yu, Agnes B. Fogo, and Charles R. Flynn

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Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice, Manuel Chiusa, Youngmin A. Lee, Ming-Zhi Zhang, Raymond C. Harris, Taylor Sherrill, Volkhard Lindner, Craig R. Brooks, Gang Yu, Agnes B. Fogo, and Charles R. Flynn

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In nondiabetic C57BL/6J mice, canagliflozin affects the skeleton in a sex- and age-dependent manner, Carolyn Chlebek, Casey McAndrews, Samantha N. Costa, Victoria E. DeMambro, Shoshana Yakar, and Clifford J. Rosen

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Delayed CCL23 response is associated with poor outcomes after cardiac arrest, Joanne T. deKay, Elena Chepurko, Vadim Chepurko, Lacey Knudsen, Christine Lord, Meghan Searight, Sergey Tsibulnikov, Michael P. Robich, Douglas Sawyer, and Teresa May

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Endothelial cells increase mesenchymal stem cell differentiation in scaffold-free 3D vascular tissue, William Gabriel DeMaria, Andre Figueroa-Milla, Abigail Kaija, Anne E. Harrington, Benjamin Tero, Larisa Ryzhova, and Lucy Liaw

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ScreenDMT reveals DiHOMEs are replicably inversely associated with BMI and stimulate adipocyte calcium influx, Jonathan M. Dreyfuss, Vera Djordjilović, Hui Pan, Valerie Bussberg, Allison M. MacDonald, Niven R. Narain, Michael A. Kiebish, Matthias Blüher, Yu-Hua Tseng, and Matthew D. Lynes

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Cellular Characteristics and Protein Signatures of Human Adipose Tissues from Donors With or Without Advanced Coronary Artery Disease, Caitlin P. Ellis, Benjamin W. Tero, Christian M. Potts, Kimberly T. Malka, Xuehui Yang, Joshua Hamilton, Calvin Vary, Andre Khalil, and Lucy Liaw

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Adipocytes and metabolism: Contributions to multiple myeloma, Heather Fairfield, Michelle Karam, Allyson Schimelman, Ya-Wei Qiang, and Michaela R. Reagan

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Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC, Jozsef Gal, Calvin Vary, Carlos A. Gartner, Gregory A. Jicha, Erin L. Abner, Yulica S. Ortega, Ibrahim Choucair, Donna M. Wilcock, Ruth S. Nelson, and Peter T. Nelson

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Navigating the Adipocyte Precursor Niche: Cell-Cell Interactions, Regulatory Mechanisms and Implications for Adipose Tissue Homeostasis, Devesh Kesharwani and Aaron C. Brown

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Neuroendocrinology of bone, Se-Min Kim, Farhath Sultana, Funda Korkmaz, Satish Rojekar, Anusha Pallapati, Vitaly Ryu, Daria Lizneva, Tony Yuen, and Clifford J. Rosen

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Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress, Ekaterina D. Korobkina, Camila Martinez Calejman, John A. Haley, Miranda E. Kelly, Huawei Li, Maria Gaughan, Qingbo Chen, and Matthew D. Lynes

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Pharmacogenetic and microRNA mechanisms of beta blocker use on bone, Christine W. Lary, Elizabeth J. Atkinson, Jennifer Spillane, Zannatun Nayema, Tyler A. Roy, Rebecca Peters, Griffin T. Scott, Hongyu Chen, Archana Nagarajan, Katherine J. Motyl, and Aaron C. Brown

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PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche, Hanghang Liu, Linyi Liu, and Clifford J. Rosen

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Calorie restriction induces mandible bone loss by regulating mitochondrial function, Linyi Liu, Phuong T. Le, Victoria E. DeMambro, Tiange Feng, Hanghang Liu, and Clifford J. Rosen

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Calorie Restriction in Mice Impairs Cortical but not Trabecular Peak Bone Mass by Suppressing Bone Remodeling, Linyi Liu, Phuong T. Le, J Patrizia Stohn, Hanghang Liu, Wangyang Ying, Roland Baron, and Clifford J. Rosen

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Transgenerational epigenetic self-memory of dosage is associated with methylation and altered growth trajectories and neonatal hormones, M Elena Martinez, Aldona Karaczyn, Zhaofei Wu, Christian A. Bennett, Kassey L. Matoin, Heather M. Daigle, and Arturo Hernandez

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Extracellular metallothionein as a therapeutic target in the early progression of Type 1 Diabetes, Clare K. Melchiorre, Matthew D. Lynes, Sadikshya Bhandari, Sheng-Chiang Su, Christian M. Potts, Amy V. Thees, Carol E. Norris, Lucy Liaw, Yu-Hua Tseng, and Michael A. Lynes

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ALK1 Signaling in Human Cardiac Progenitor Cells Promotes a Pro-angiogenic Secretome, Michayla Moore, Sergey Ryzhov, Douglas Sawyer, Carlos Gartner, and Calvin Vary

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Network analysis of brain and bone tissue transcripts reveals shared molecular mechanisms underlying Alzheimer's Disease and related dementias (ADRD) and Osteoporosis, Archana Nagarajan, Jason Laird, Obiadada Ugochukwu, Sjur Reppe, Kaare Gautvik, Ryan D. Ross, David A. Bennett, and Clifford J. Rosen

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Patients' Perspectives on Health-Related Social Needs and Recommendations for Interventions: A Qualitative Study, Tessa K. Novick, Michelle Osuna, Caroline Emery, Francisco Barrios, Daniel Ramirez, Deidra C. Crews, and Elizabeth Jacobs

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Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration, Shivangi Pande, Calvin Vary, Xuehui Yang, Lucy Liaw, Lindsey Gower, Robert Friesel, Igor Prudovsky, and Sergey Ryzhov

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Tranexamic acid reduces inflammation, edema and burn wound conversion in a rodent model, Igor Prudovsky, Doreen Kacer, Volkhard Lindner, Joseph Rappold, and Damien Wilson Carter

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Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB, Janane F. Rahbani, Jakub Bunk, Damien Lagarde, Bozena Samborska, Anna Roesler, Abhirup Shaw, Zafir Kaiser, Jessica L. Braun, Mia S. Geromella, and Robert A. Koza

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Viral Variants, Vaccinations, and Long Covid - New Insights., Clifford J Rosen

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Effects of a Global Null Mutation on Murine PVAT and Cardiovascular Function, Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L. Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, and Lucy Liaw

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Magnitude of obesity alone does not alter the alveolar lipidome, William G. Tharp, Carolyn R. Morris, Yulica Santos-Ortega, and Calvin Vary

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Light-responsive adipose-hypothalamus axis controls metabolic regulation, Tadataka Tsuji, Vladimir Tolstikov, Yang Zhang, Tian Lian Huang, Henrique Camara, Meghan Halpin, Niven R. Narain, King-Wai Yau, and Matthew D. Lynes

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Mice lacking DIO3 exhibit sex-specific alterations in circadian patterns of corticosterone and gene expression in metabolic tissues, Zhaofei Wu, M Elena Martinez, and Arturo Hernandez

Submissions from 2023

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Purification of functional mouse skeletal muscle mitochondria using percoll density gradient centrifugation, Rea Victoria Anunciado-Koza, Anyonya R. Guntur, Calvin P. Vary, Carlos A. Gartner, Madeleine Nowak, and Robert A. Koza

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Community risks for SARS-CoV-2 infection among fully vaccinated US adults by rurality: A retrospective cohort study from the National COVID Cohort Collaborative, Alfred Jerrod Anzalone, Jing Sun, Amanda J. Vinson, William H. Beasley, William B. Hillegass, and Kim Murray

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Navigating Uncertainty in Public Health Decisionmaking: The Role of a Value of Information Framework in Threat Agnostic Biosurveillance, Jalal Awan, Laura J. Faherty, and Henry H. Willis

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Post or Perish? Social Media Strategies for Disseminating Orthopedic Research, Evan G. Buettmann, Carolyn Chlebek, Carly A. Lockard, Sade W. Clayton, Karl J. Lewis, and Kelsey H. Collins

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Tickborne Diseases, Alison E. Burke, Kimberly Knoper, Emily Ling, Robert P. Smith, Darren Taichman, and Sam R. Telford

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Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth, Jennifer M. Caron, Xianghua Han, Christine W. Lary, Pradeep Sathyanarayana, Scot C. Remick, and Marc S. Ernstoff

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Effects of PTH on osteoblast bioenergetics in response to glucose, Victoria E. DeMambro, Li Tian, Vivin Karthik, Clifford J. Rosen, and Anyonya R. Guntur

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Role of resistance training in bone macro and micro damages in an estrogen absence animal model, Graziéle F. Deriggi-Pisani, Uliana S. Stotzer, Rita C. Marqueti, Maria F. Rodrigues, Bruna G. Biffe, Karina A. Silva, Victor Fabricio, Clifford J. Rosen, and Heloisa S. Sobreiro de Araujo

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Single-cell transcriptomics of bone marrow stromal cells in Diversity Outbred mice: a model for population-level scRNA-seq studies, Luke J. Dillard, Will T. Rosenow, Gina M. Calabrese, Larry D. Mesner, Basel M. Al-Barghouthi, Abdullah Abood, and Clifford J. Rosen

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Optogenetic activation of UCP1-dependent thermogenesis in brown adipocytes, Chad C. Doucette, Daniel C. Nguyen, Davide Barteselli, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, and Aaron C. Brown

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Irisin Enhances Mitochondrial Function in Osteoclast Progenitors during Differentiation, Eben Estell, Tsunagu Ichikawa, Paige Giffault, Lynda Bonewald, Bruce Spiegelman, and Clifford Rosen

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Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression, Jason V. Evans, Shankar Suman, Mounika Uttam Goruganthu, Elena E. Tchekneva, Shuxiao Guan, Rajeswara Rao Arasada, Anneliese Antonucci, Longzhu Piao, and Sergey Ryzhov

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Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling, Yi Fan, Ping Lyu, Ruiye Bi, Chen Cui, Ruoshi Xu, Clifford J. Rosen, Quan Yuan, and Chenchen Zhou

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Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signalin, Mariah Farrell, Heather Fairfield, Michelle Karam, Anastasia D'Amico, Connor S. Murphy, Carolyne Falank, Romanos Sklavenitis Pistofidi, Amanda Cao, Catherine R. Marinac, Julie A. Dragon, Lauren McGuinness, Carlos G. Gartner, and Reagan Di Iorio

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Thyroid Hormone Metabolism: A Historical Perspective, Valerie Anne Galton and Arturo Hernandez

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Epigenetic developmental programming and intergenerational effects of thyroid hormones, Arturo Hernandez, M Elena Martinez, Carolina Chaves, and Joao Anselmo

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Circulating neutrophil extracellular trap (NET)-forming 'rogue' neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19-, Victoria L. Herrera, Nicholas A. Bosch, Judith J. Lok, Mai Q. Nguyen, Kaitriona A. Lenae, Joanne T. deKay, Sergey V. Ryzhov, and David Seder

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A Novel ENU-Induced Mutation Causes Motor Deficits in Mice without Causing Peripheral Neuropathy, Timothy J. Hines, Janice Bailey, Hedi Liu, Anyonya R. Guntur, Kevin L. Seburn, Samia L. Pratt, Jonathan R. Funke, Lisa M. Tarantino, and Robert W. Burgess

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Thermoneutral housing does not rescue olanzapine-induced trabecular bone loss in C57BL/6J female mice, Audrie L. Langlais, Rebecca V. Mountain, Roni F. Kunst, Deborah Barlow, Karen L. Houseknecht, and Katherine J. Motyl

PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner, Hanghang Liu, Akane Wada, Isabella Le, Phuong T. Le, Andrew W. Lee, and Jun Zhou

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New Insights into Calorie Restriction Induced Bone Loss, Linyi Liu and Clifford J. Rosen

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The Multifaceted Roles of Bone Marrow Adipocytes in Bone and Hematopoietic Homeostasis, Ziru Li and Clifford J. Rosen

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A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 as a Negative Regulator of Glucose Uptake in Brown Adipocytes, Matthew D. Lynes, Qian Huang, Carolina Cora, Sheng-Chiang Su, Peng Yi, and Yu-Hua Tseng

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The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc, Vedavathi Madhu, Miriam Hernandez-Meadows, Paige K. Boneski, Yunping Qiu, Anyonya R. Guntur, and Irwin J. Kurland

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Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system, Maria Elena Martinez, Zhaofei Wu, and Arturo Hernandez

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Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells, Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F. Pansa, Sofía Carbajosa, Aaron C. Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P. Madauss, Gastón Soria, and Vanesa Gottifredi

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Phylodynamics of deer tick virus in North America, Rebekah J. McMinn, Rose M. Langsjoen, Andrei Bombin, Rebecca M. Robich, Erick Ojeda, Erick Ojeda, Erica Normandin, Heidi K. Goethert, Charles B. Lubelczyk, Elizabeth Schneider, Danielle Cosenza, Molly Meagher, Melissa A. Prusinski, Pardis C. Sabeti, Robert P. Smith, Sam R. Telford, Anne Piantadosi, and Gregory D. Ebel

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Bring the heat: Thermal stress, metabolic plasticity, and considerations for biomedical research, Katherine J. Motyl and Ormond A. MacDougald

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Social isolation through single housing negatively affects trabecular and cortical bone in adult male, but not female, C57BL/6J mice, Rebecca V. Mountain, Audrie L. Langlais, Dorothy Hu, Roland Baron, Christine W. Lary, and Katherine J. Motyl

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Toward Comprehensive Care for Long Covid, Janko Ž. Nikolich and Clifford J. Rosen

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Raising the Bar for Language Equity Health Care Research, Pilar Ortega, Mónica Vela, and Elizabeth A. Jacobs

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Peer Review in a General Medical Research Journal Before and During the COVID-19 Pandemic, Roy H. Perlis, Jacob Kendall-Taylor, Kamber Hart, Ishani Ganguli, Jesse A. Berlin, Steven M. Bradley, Sebastien Haneuse, Sharon K. Inouye, Elizabeth A. Jacobs, Arden Morris, Olugbenga Ogedegbe, Eli Perencevich, Lawrence N. Shulman, N Seth Trueger, Stephan D. Fihn, Frederick P. Rivara, and Annette Flanagin

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Antagonizing the Leptin Receptor in Obesity, Clifford J. Rosen

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Optimizing a therapeutic humanized follicle-stimulating hormone-blocking antibody formulation by protein thermal shift assay, Damini Sant, Satish Rojekar, Sakshi Gera, Anusha R. Pallapati, Judit Gimenez-Roig, Tan-Chun Kuo, and Clifford J. Rosen

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Editorial: Obesity and cancer: update on etiology, molecular biomarkers and biotargets, clinical strategies, and epidemiology, Eva Surmacz, Valentina Guarnotta, and Michaela Ruth Reagan

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Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis, Barbara Toomey, Sarah A. Mitrovic, Maia Lindner-Liaw, Ruth G. Leon Vazquez, Doreen Kacer, Sergey Ryzhov, and Igor Prudovsky

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Age-related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment, Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina DiPietro, Emma Paradie, Benjamin Tero, Anne Harrington, Larisa Ryzhova, Lucy Liaw, Peter C. Reifsnyder, David E. Harrison, and Kristy L. Townsend

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Notch Signaling Regulates Mouse Perivascular Adipose Tissue Function via Mitochondrial Pathways, Chenhao Yang, Xuehui Yang, Anne Harrington, Christian Potts, Abigail Kaija, Larisa Ryzhova, and Lucy Liaw

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Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells, Xuehui Yang, Chenhao Yang, Robert E. Friesel, and Lucy Liaw

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Bone circuitry and interorgan skeletal crosstalk, Mone Zaidi, Se-Min Kim, Mehr Mathew, Funda Korkmaz, Farhath Sultana, Sari Miyashita, Anisa Azatovna Gumerova, Tal Frolinger, Ofer Moldavski, Orly Barak, Anusha Pallapati, Satish Rojekar, John Caminis, Yelena Ginzburg, Vitaly Ryu, Terry F. Davies, Daria Lizneva, Clifford J. Rosen, and Tony Yuen

Submissions from 2022

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The effect of short-term high-caloric feeding and fasting on bone microarchitecture, Miriam A. Bredella, Pouneh K. Fazeli, Jenna Bourassa, Clifford J. Rosen, Mary L. Bouxsein, Anne Klibanski, and Karen K. Miller

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The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease, Carolyn Chlebek and Clifford J. Rosen

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Parathyroid Disorders Special Sections, Roberto Civitelli and Clifford J. Rosen

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The number of circulating CD26 expressing cells is decreased in critical COVID-19 illness, Joanne T. deKay, Teresa L. May, Richard R. Riker, Jonathan Rud, David J. Gagnon, Douglas B. Sawyer, David B. Seder, and Sergey Ryzhov

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Potential Mechanisms of Gut-Derived Extracellular Vesicle Participation in Glucose and Lipid Homeostasis, Tiange Feng, Weizhen Zhang, and Ziru Li

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FSH-blocking therapeutic for osteoporosis, Sakshi Gera, Tan-Chun Kuo, Anisa Azatovna Gumerova, Funda Korkmaz, Damini Sant, Victoria DeMambro, Karthyayani Sudha, Ashley Padilla, Geoffrey Prevot, Jazz Munitz, and Abraham Teunissen

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A critical bioenergetic switch is regulated by IGF2 during murine cartilage development, Judith M. Hollander, Lingyun Li, Miraj Rawal, Si Kun Wang, Yue Shu, Ming Zhang, Heber C. Nielsen, Clifford J. Rosen, and Li Zeng

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Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial, Kim M. Huffman, Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, Margery A. Connelly, Carl F. Pieper, Melissa Orenduff, Leanna M. Ross, Megan E. Ramaker, James L. Dorling, Clifford J. Rosen, Irina Shalaurova, James D. Otvos, Virginia B. Kraus, and William E. Kraus

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Thyroid hormone elicits intergenerational epigenetic effects on adult social behavior and fetal brain expression of autism susceptibility genes, Maria Elena Martinez, Julia Patrizia Stohn, Elizabeth M. Mutina, Rayne J. Whitten, and Arturo Hernandez

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DIO3 protects from thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities, M Elena Martinez, Ilka Pinz, Marilena Preda, Christine R. Norton, Thomas Gridley, and Arturo Hernandez

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Health care professional perspectives on discharging hospitalized patients with injection drug use-associated infections, Nichole Moore, Michael Kohut, Henry Stoddard, Debra Burris, Frank Chessa, Monica K. Sikka, Daniel Solomon, Colleen M. Kershaw, Ellen Eaton, Rebecca Hutchinson, Kathleen M. Fairfield, Thomas J. Stopka, Peter Friedmann, and Kinna Thakarar

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ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP, Janane F. Rahbani, Charlotte Scholtes, Damien M. Lagarde, Mohammed F. Hussain, Anna Roesler, Christien B. Dykstra, Jakub Bunk, Bozena Samborska, Shannon L. O'Brien, Emma Tripp, Alain Pacis, Anthony R. Angueira, Olivia S. Johansen, Jessica Cinkornpumin, Ishtiaque Hossain, Matthew D. Lynes, Yang Zhang, Andrew P. White, William A. Pastor, Maria Chondronikola, Labros Sidossis, Samuel Klein, and Anastasia Kralli

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Diversity in Clinical Trials - Next Steps, Clifford J. Rosen, Nakela L. Cook, and Consuelo H. Wilkins

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Vitamin D and Incident Fractures. Reply, Clifford J. Rosen and Steve Cummings

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Impact of multimodal dermatoscopy training on skin biopsies by primary care providers, Elizabeth V. Seiverling, Kathryn Stevens, Gregory Dorr, Madeline A. Prentiss, Henry Stoddard, Laura Houk, Peg Cyr, and Hadjh Ahrns

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Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development, John P. Sundberg, Hannah Galantino-Homer, Heather Fairfield, Patricia F. Ward-Bailey, Belinda S. Harris, Melissa Berry, C Herbert Pratt, Nicholas E. Gott, Lesley S. Bechtold, Pauline R. Kaplan, Blythe P. Durbin-Johnson, David M. Rocke, and Robert H. Rice

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Quantification of Lipid Area within Thermogenic Mouse Perivascular Adipose Tissue Using Standardized Image Analysis in FIJI, Benjamin W. Tero, Bethany Fortier, Ashley N. Soucy, Ginger Paquette, and Lucy Liaw

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Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration, Robert J. Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R. Guntur, Jennifer Simkin, and Mimi C. Sammarco

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Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure, Kristy L. Townsend, Eleanor Pritchard, Jeannine M. Coburn, Young Mi Kwon, Magdalena Blaszkiewicz, Matthew D. Lynes, David L. Kaplan, and Yu-Hua Tseng

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Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation, Zhaofei Wu, M Elena Martinez, Victoria DeMambro, Marie Francois, and Arturo Hernandez

Submissions from 2021

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FOXD1 regulates cell division in clear cell renal cell carcinoma, Kyle H. Bond, Jennifer L. Fetting, Christine W. Lary, Ivette F. Emery, and Leif Oxburgh

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DEspR neutrophils are associated with critical illness in COVID-19, Joanne T. deKay, Ivette F. Emery, Jonathan Rud, Ashley Eldridge, Christine Lord, David J. Gagnon, and Teresa L. May

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Notch1 and Notch2 collaboratively maintain radial glial cells in mouse neurogenesis, Shun Mase, Atsunori Shitamukai, Quan Wu, Mitsuru Morimoto, Thomas Gridley, and Fumio Matsuzaki

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Protective role of ErbB3 signaling in myeloid cells during adaptation to cardiac pressure overload, Haifeng Yin, Amanda J. Favreau-Lessard, Joanne T. deKay, Yodit R. Herrmann, Michael P. Robich, Robert A. Koza, Igor Prudovsky, Douglas B. Sawyer, and Sergey Ryzhov

Submissions from 2020

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How Dietary Deficiency Studies Have Illuminated the Many Roles of Vitamin A During Development and Postnatal Life, Mary Ann Asson-Batres

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Notch Dosage Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice, Christopher A. Blackwood, Alessandro Bailetti, Sayan Nandi, Thomas Gridley, and Jean M. Hébert

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Stromal SNAI2 is required for ERBB2 breast cancer progression., Adrián Blanco-Gómez, Lourdes Hontecillas-Prieto, Roberto Corchado-Cobos, Natalia García-Sancha, Nélida Salvador, Andrés Castellanos-Martín, María Del Mar Sáez-Freire, Marina Mendiburu-Eliçabe, Diego Alonso-López, Javier De Las Rivas, Mar Lorente, Ana García-Casas, Sofía Del Carmen, María Del Mar Abad-Hernández, Juan Jesús Cruz-Hernández, César Augusto Rodríguez-Sánchez, Juncal Claros-Ampuero, Begoña García-Cenador, Javier García-Criado, Akira Orimo, Thomas Gridley, Jesús Pérez-Losada, and Sonia Castillo-Lluva

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High ErbB3 activating activity in human blood is not due to circulating neuregulin-1 beta, Emmanuel Boateng, Joanne T. deKay, Sarah M. Peterson, Jacob Boles, Nathan Pinnette, Mary W. Sorcher, Michael P. Robich, Douglas B. Sawyer, and Sergey Ryzhov