The clinical and translational research community at MMCRI is a closely-linked, multi-disciplinary scientific enterprise in which basic, clinical and translational researchers plan and conduct studies as collaborators and scientific colleagues. With the three part mission of research, education and patient care as our guide, we bridge the interdisciplinary divide between clinical, translational, and basic research.

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Submissions from 2019

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The effect of raloxifene on bone marrow adipose tissue and bone turnover in postmenopausal women with osteoporosis., Kerensa M Beekman, Annegreet G Veldhuis-Vlug, Martin den Heijer, Mario Maas, Ania M Oleksik, Michael W Tanck, Susan M Ott, Rob J van 't Hof, Paul Lips, Peter H Bisschop, and Nathalie Bravenboer

Submissions from 2018

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High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice., Adriana Lelis Carvalho, Victoria E DeMambro, Anyonya R Guntur, Phuong Le, Kenichi Nagano, Roland Baron, Francisco José Albuquerque de Paula, and Katherine J Motyl

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The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis., Heather Fairfield, Carolyne Falank, Elizabeth Harris, Victoria Demambro, Michelle McDonald, Jessica A Pettitt, Sindhu T Mohanty, Peter Croucher, Ina Kramer, Michaela Kneissel, Clifford J Rosen, and Michaela R Reagan

Submissions from 2017

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Structure and function of bone marrow adipocytes., Francisco José Albuquerque de Paula and Clifford J. Rosen

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Bone marrow adipocytes., Mark C Horowitz, Ryan Berry, Brandon Holtrup, Zachary Sebo, Tracy Nelson, Jackie A Fretz, Dieter Lindskog, Jennifer L Kaplan, Gene Ables, Matthew S Rodeheffer, and Clifford J Rosen

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A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice., Katherine J Motyl, Megan Beauchemin, Deborah Barlow, Phuong T Le, Kenichi Nagano, Annika Treyball, Anisha Contractor, Roland Baron, Clifford J Rosen, and Karen L Houseknecht

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Energy metabolism of bone., Katherine J Motyl, Anyonya R Guntur, Adriana Lelis Carvalho, and Clifford J Rosen

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New insights into fuel choices of nephron progenitor cells., Leif Oxburgh and Clifford J Rosen

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A perspective on malignancy in the marrow., Michaela R Reagan, Jane B Lian, Clifford J Rosen, and Gary S Stein

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Cover image, volume 232, number 12, December 2017., Michaela R Reagan, Jane B Lian, Clifford J Rosen, and Gary S Stein

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Intracellular lipid droplets support osteoblast function., Elizabeth Rendina-Ruedy, Anyonya R Guntur, and Clifford J Rosen

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An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth., Tomoya Uchimura, Judith M Hollander, Daisy S Nakamura, Zhiyi Liu, Clifford J. Rosen, Irene Georgakoudi, and Li Zeng

Submissions from 2016

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HP1BP3 expression determines maternal behavior and offspring survival., B P Garfinkel, S Arad, S M Neuner, S Netser, S Wagner, C C Kaczorowski, C J. Rosen, M Gal, H Soreq, and J Orly

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Cardiac and renovascular complications in type 2 diabetes--is there hope?, Julie R. Ingelfinger and Clifford J. Rosen

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Building better bones with biologics - a new approach to osteoporosis?, Clifford J Rosen and Julie R Ingelfinger

Submissions from 2015

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A high fat diet increases bone marrow adipose tissue (MAT) but does not alter trabecular or cortical bone mass in C57BL/6J mice., Casey R Doucette, Mark C Horowitz, Ryan Berry, Ormond A MacDougald, Rea Anunciado-Koza, Robert A Koza, and Clifford J Rosen

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Proportionate dwarfism in mice lacking heterochromatin protein 1 binding protein 3 (HP1BP3) is associated with alterations in the endocrine IGF-1 pathway., Benjamin P Garfinkel, Shiri Arad, Phuong T Le, Michael Bustin, Clifford J Rosen, Yankel Gabet, and Joseph Orly

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PTHrp comes full circle in cancer biology., Anyonya R Guntur, Casey R Doucette, and Clifford J Rosen

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Cardiovascular risk and sodium-glucose cotransporter 2 inhibition in type 2 diabetes., Julie R Ingelfinger and Clifford J Rosen

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Energy excess, glucose utilization, and skeletal remodeling: new insights., Beata Lecka-Czernik and Clifford J Rosen

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Propranolol attenuates risperidone-induced trabecular bone loss in female mice., Katherine J Motyl, Victoria E DeMambro, Deborah Barlow, David Olshan, Kenichi Nagano, Roland Baron, Clifford J Rosen, and Karen L Houseknecht

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Questions about vitamin D for primary care practice: input from an NIH conference., Christine L Taylor, Paul R Thomas, John F Aloia, Peter S Millard, and Clifford J Rosen

Submissions from 2014

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Bioenergetics during calvarial osteoblast differentiation reflect strain differences in bone mass., Anyonya R Guntur, Phuong T Le, Charles R Farber, and Clifford J Rosen

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Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity., Shriram Nallamshetty, Phuong T Le, Hong Wang, Maya J Issacsohn, David J Reeder, Eun-Jung Rhee, Florian W Kiefer, Jonathan D Brown, Clifford J Rosen, and Jorge Plutzky

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The epidemiology and pathogenesis of osteoporosis., Clifford J. Rosen

Submissions from 2013

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IGF-1 regulation of key signaling pathways in bone., Anyonya R Guntur and Clifford J Rosen