The Center for Molecular Medicine (CMM) was established in 1997 as a Center within Maine Medical Center Research Institute with the vision of performing cutting edge biomedical research to discover the molecular mechanisms of human disease, and to harness new knowledge in developmental biology and stem cells for regenerative medicine approaches. The investigators at CMM are committed to translating basic science discoveries to innovative approaches to diagnose and treat human disease.

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Submissions from 2014

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Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis., Xiang Hua Han, Yong-Ri Jin, Leonard Tan, Tatiana Kosciuk, Jin-Seon Lee, and Jeong Kyo Yoon

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Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity., Qing He, Xuehui Yang, Yan Gong, Dmitry Kovalenko, Ernesto Canalis, Clifford J Rosen, and Robert E Friesel

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Effect of sustained postnatal systemic inflammation on hippocampal volume and function in mice., Shadi N Malaeb, Jonathan M Davis, Ilka M Pinz, Jennifer L Newman, Olaf Dammann, and Maribel Rios

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Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions., M Elena Martinez, Marika Charalambous, Aabida Saferali, Steven Fiering, Anna K Naumova, Donald St Germain, Anne C Ferguson-Smith, and Arturo Hernandez

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Bone morphogenetic protein signaling in nephron progenitor cells., Leif Oxburgh, Aaron C. Brown, Sree Deepthi Muthukrishnan, and Jennifer L. Fetting

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Common features of microRNA target prediction tools., Sarah M Peterson, Jeffrey A Thompson, Melanie L Ufkin, Pradeep Sathyanarayana, Lucy Liaw, and Clare Bates Congdon

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Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation., Ashleigh Poole, Nicholas Knowland, Emily Cooper, Rebecca Cole, Hongchuan Wang, Lucas Booth, Doreen Kacer, Francesca Tarantini, Robert Friesel, and Igor Prudovsky

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Notch signal integration in the vasculature during remodeling., Bahman Rostama, Sarah M Peterson, Calvin P H Vary, and Lucy Liaw

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miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia., Melanie L Ufkin, Sarah Peterson, Xuehui Yang, Heather Driscoll, Christine Duarte, and Pradeep Sathyanarayana

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Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction., Ting Wang, Linden A Green, Samir K Gupta, Chul Kim, Liang Wang, Sharilyn Almodovar, Sonia C Flores, Igor A Prudovsky, Paul Jolicoeur, Ziyue Liu, and Matthias Clauss

Submissions from 2013

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The snail family gene snai3 is not essential for embryogenesis in mice., Cara K Bradley, Christine R Norton, Ying Chen, Xianghua Han, Carmen J Booth, Jeong Kyo Yoon, Luke T Krebs, and Thomas Gridley

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Role for compartmentalization in nephron progenitor differentiation., Aaron C Brown, Sree Deepthi Muthukrishnan, Justin A Guay, Derek C Adams, Dillon A Schafer, Jennifer L Fetting, and Leif Oxburgh

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Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis., Ying Chen and Thomas Gridley

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The SNAI1 and SNAI2 proteins occupy their own and each other's promoter during chondrogenesis., Ying Chen and Thomas Gridley

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Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src., Yan Gong, Xuehui Yang, Qing He, Lindsey Gower, Igor Prudovsky, Calvin P H Vary, Peter C Brooks, and Robert E Friesel

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Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis., Yuefeng Tang, Hao Bai, Sumithra Urs, Zack Wang, and Lucy Liaw

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Spry1 and Spry4 differentially regulate human aortic smooth muscle cell phenotype via Akt/FoxO/myocardin signaling., Xuehui Yang, Yan Gong, Yuefeng Tang, Hongfang Li, Qing He, Lindsey Gower, Lucy Liaw, and Robert E Friesel

Submissions from 2012

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Insulin-like growth factor binding protein-4 differentially inhibits growth factor-induced angiogenesis., Liangru W Contois, Desiree P Nugent, Jennifer M Caron, Alexandra Cretu, Eric Tweedie, Abebe Akalu, Leonard Liebes, Robert Friesel, Clifford Rosen, Calvin Vary, and Peter C Brooks

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The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice., Luke T Krebs, Cara K Bradley, Christine R Norton, Jingxia Xu, Kathleen F Oram, Christa Starling, Michael L Deftos, Michael J Bevan, and Thomas Gridley

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Cthrc1, a novel circulating hormone regulating metabolism., J Patrizia Stohn, Nicole G Perreault, Qiaozeng Wang, Lucy Liaw, and Volkhard Lindner

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Histone deacetylase activity selectively regulates notch-mediated smooth muscle differentiation in human vascular cells., Yuefeng Tang, Joshua M Boucher, and Lucy Liaw

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Mortality in rural locations after severe injuries from motor vehicle crashes., Lori L Travis, David E Clark, Amy E Haskins, and Joseph A Kilch

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Cellular signaling and biological functions of R-spondins., Jeong Kyo Yoon and Jin-Seon Lee

Submissions from 2011

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Isolation and culture of cells from the nephrogenic zone of the embryonic mouse kidney., Aaron C Brown, Ulrika Blank, Derek C Adams, Michele J Karolak, Jennifer L Fetting, Beth L Hill, and Leif Oxburgh

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BMP signaling in the nephron progenitor niche., Leif Oxburgh, Aaron C Brown, Jennifer Fetting, and Beth Hill

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Endoglin regulates cancer-stromal cell interactions in prostate tumors., Diana Romero, Christine O'Neill, Aleksandra Terzic, Liangru Contois, Kira Young, Barbara A Conley, Raymond C Bergan, Peter C Brooks, and Calvin P H Vary

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Mechanisms of TGF-β-induced differentiation in human vascular smooth muscle cells., Yuefeng Tang, Xuehui Yang, Robert E Friesel, Calvin P H Vary, and Lucy Liaw

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SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis., Berna Uygur and Wen-Shu Wu

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RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction., Deepak Venkatesh, Natalie Fredette, Bahman Rostama, Yuefeng Tang, Calvin P H Vary, Lucy Liaw, and Sumithra Urs

Submissions from 2010

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Follistatin-like 1 regulates renal IL-1β expression in cisplatin nephrotoxicity., Derek C Adams, Michele J Karolak, Barry W Larman, Lucy Liaw, James D Nolin, and Leif Oxburgh

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Two novel human NUMB isoforms provide a potential link between development and cancer., Aldona Karaczyn, Mahmud Bani-Yaghoub, Roger Tremblay, Chris Kubu, Rebecca Cowling, Tamara L Adams, Igor Prudovsky, Douglas Spicer, Robert Friesel, Calvin Vary, and Joseph M Verdi

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A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway., Nicholas Matluk, Jennifer A Rochira, Aldona Karaczyn, Tamara Adams, and Joseph M Verdi

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Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration., Diana Romero, Aleksandra Terzic, Barbara A Conley, Clarissa S Craft, Borko Jovanovic, Raymond C Bergan, and Calvin P H Vary

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The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells., Yuefeng Tang, Anne Harrington, Xuehui Yang, Robert E Friesel, and Lucy Liaw

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Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation., Yuefeng Tang, Sumithra Urs, Joshua Boucher, Tyler Bernaiche, Deepak Venkatesh, Douglas B Spicer, Calvin P H Vary, and Lucy Liaw