Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2022

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Pilot Study of an Encounter Decision Aid for Lung Cancer Screening, Mayuko Ito Fukunaga, Akshu Balwan, Jaclyn A. Janis, Caitlin Gutheil, Jason Yahwak, and Paul K. Han

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Racial And Ethnic Disparities In COVID-19 Booster Uptake, Lawrence Baker, Brian Phillips, Laura J. Faherty, Jeanne S. Ringel, and Ashley M. Kranz

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Recreational Dissociation Leading to Bloody Urination, Cynthia Gaudet, Joshua Swenson, Diana Biggs, and Michelle Crispo

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The ABLE Anterior-Based Muscle-Sparing Approach: A Safe and Effective Option for Total Hip Arthroplasty, Adam J. Rana, Callahan M. Sturgeon, Brian J. McGrory, Michael V. Frazier, and George M. Babikian

Validating the Brain Injury Guidelines: Results of an American Association for the Surgery of Trauma prospective multi-institutional trial, Bellal Joseph, Omar Obaid, Linda Dultz, George Black, Marc Campbell, Daniel Cullinane, and et. al

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Woman With Cardiac Arrest, Christina Wilson, David Mackenzie, Peter Croft, John Hansen, Joshua Rehberg, and Andrew Fried

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The Role of Pharmacotherapeutic Agents in Children with Desmoid Tumors, Aaron R. Weiss

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Update and Renewal of a National Internal Medicine Curriculum for Medical Students: Process and Outcomes, Laura J. Zakowski, Nadia L. Bennett, Shobhina Chheda, Ernie Esquivel, Sara B. Fazio, Chad S. Miller, L James Nixon, and Robert Trowbridge Jr

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Cardiac Arrest Treatment Center Differences in Sedation and Analgesia Dosing During Targeted Temperature Management, Teresa L. May, David B. Seder, and Richard R. Riker

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VITAL Findings - A Decisive Verdict on Vitamin D Supplementation, Steven R. Cummings and Clifford J. Rosen

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Association of Vitamin D Prescribing and Clinical Outcomes in Adults Hospitalized with COVID-19, Kathleen M. Fairfield, Kimberly A. Murray, A Jerrod Anzalone, William Beasley, Maryam Khodaverdi, Sally L. Hodder, Jeremy Harper, Susan Santangelo, Clifford J. Rosen, and On Behalf Of The N C Consortium

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In silico discovery of blood cell macromolecular associations, Alexandra C. Hinton and Christine W. Lary

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Opioid Prescribing Patterns Before, During, and After Critical Illness: An Observational Study, Chelsea Wampole, Ariel McKenna, Richard R. Riker, Teresa L. May, David B. Seder, Dawn Abram, Gilles L. Fraser, and David J. Gagnon

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Social and maternal behavior in mesoderm specific transcript (Mest)-deficient mice, Rea P. Anunciado-Koza, J Patrizia Stohn, Arturo Hernandez, and Robert A. Koza

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The impact of the COVID-19 pandemic on people who inject drugs accessing harm reduction services in an rural American state, Kinna Thakarar, Michael Kohut, Rebecca Hutchinson, Debra Burris, and Kathleen M. Fairfield

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Correction to: Severity of traumatic adrenal injury does not meaningfully affect clinical outcomes, Bryan C. Morse

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Letermovir for Cytomegalovirus Prevention in Adolescent Patients Following Hematopoietic Cell Transplantation, Nicole P Daukshus, Anthony Cirincione, Molly Siver, Sherry Mathew, Binni Kunvarjee, Amelia Chan, Jaap Jan Boelens, Susan K. Seo, Genovefa A. Papanicolaou, and Nancy A. Kernan

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Long-Term Adaptation Among Adolescent and Young Adult Children to Familial Cancer Risk, Susan Miesfeldt

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Coronary Angiographic Findings For Out-of-Hospital Cardiac arrest Survivors Presenting With Nonshockable Rhythms and no ST Elevation Post Resuscitation, D B. Seder

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Testing and Nonpharmaceutical Interventions for Prevention of SARS-CoV-2 in 20 US Overnight Camps in Summer 2021, Laura Blaisdell, Josh Rising, André van Zyl, Julia Finn, and Jeff Vergales

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Cancers Among Adolescents and Young Adults in Maine 2001-2017: A Descriptive Analysis and Model for Future Studies, S Ashley Speckhart

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Criteria for Defining Stages of Cardiogenic Shock Severity, Andrew Schwartzman

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Innovation in Breast Surgery: Practical and Ethical Considerations, Paige Teller

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Cardiovascular disease associated with methamphetamine use: a review, Jared Tobolski, Douglas B. Sawyer, Sharon J. Song, and Maxwell Eyram Afari

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Paediatric Strategy Forum for medicinal product development of multi-targeted kinase inhibitors in bone sarcomas: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration, Aaron R. Weiss

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Syphilitic Uveitis and Alopecia, Brandon Kyle Winward

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Abnormal infant neurobehavior and later neurodevelopmental delays in children with critical CHD, Thomas A. Miller

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Case 21-2022: A 17-Year-Old Girl with Fever and Cough, Mary C. Ottolini, Randheer Shailam, Amita Sharma, and Ivy A. Rosales

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Over-the-counter alkali agents to raise urine pH and citrate excretion: a prospective crossover study in healthy adults, Johann Ingimarsson

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Serum PFAS and Urinary Phthalate Biomarker Concentrations and Bone Mineral Density in 12-19 Year Olds: 2011-2016 NHANES, Jenny L. Carwile, Shravanthi M. Seshasayee, Clifford J. Rosen, and Abby F. Fleisch

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Tranexamic acid: Beyond antifibrinolysis, Igor Prudovsky, Doreen Kacer, Victoria Vieira Zucco, Monica Palmeri, Carolyne Falank, Robert Kramer, Damien Carter, and Joseph Rappold

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Severity of traumatic adrenal injury does not meaningfully affect clinical outcomes, Jonathan Nguyen, Ndidi Ude, Nikolas Holloway, Yasmin Tootla, Krystal Archer-Arroyo, Joseph Novack, James Tran, Andrew Isaacson, Mack Drake, Randi N. Smith, Jason Sciarretta, Kahdi Udobi, Richard Sola Jr, Bryan C. Morse, and et. al

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The practice and embodiment of "goofballs": A qualitative study exploring the co-injection of methamphetamines and opioids, Kinna Thakarar

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An educational intervention to facilitate appropriate subspecialty referrals: a study assessing resident communication skills, Mary Ottolini

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An educational intervention to facilitate appropriate subspecialty referrals: a study assessing resident communication skills, Mary Ottolini

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An ordinal severity scale for COVID-19 retrospective studies using Electronic Health Record data, Maryam Khodaverdi, Bradley S. Price, J Zachary Porterfield, H Timothy Bunnell, Michael T. Vest, Alfred Jerrod Anzalone, Jeremy Harper, Wes D. Kimble, Hamidreza Moradi, Brian Hendricks, Susan L. Santangelo, and Sally L. Hodder

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Drug-Eluting Stents are Associated with Superior Mid-Term Outcomes for the Treatment of Infrainguinal Bypass Graft Stenoses, Sarah E. Deery MD, MPH; Caitlin W. Hicks; David Stonko; Yasaman Kavousi; James H. Black; Ying Wei Lum; Bruce A. Perler; and Christopher J. Abularrage

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Smooth Muscle Cell Notch2 Is Not Required for Atherosclerotic Plaque Formation in ApoE Null Mice, Jessica Davis-Knowlton, Jacqueline E. Turner, Anne Harrington, and Lucy Liaw

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Female Sex Is Associated with More Reinterventions After Endovascular and Open Interventions for Intermittent Claudication, Kristina A. Giles

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Reduction and Resolution of a Hiatal Hernia Using Osteopathic Manipulative Treatment: A Case Report, Mikhail Volokitin, Anthony Song, Meredith T. Peck, and Susan Milani

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Changes in community providers' screening behaviours, referral practices, and clinical confidence following participation in an early psychosis educational campaign, Zachary B. Millman, Michelle L. West, Heather Thibeau, A Simone Sanders, Margaret Guyer, Matcheri Keshavan, Megan Lilly, Michelle Friedman-Yakoobian, Kristen A. Woodberry, Kelsey A. Johnson, and Emily R. Kline

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Comment: A Review of Pharmacologic Neurostimulant Use During Rehabilitation and Recovery After Brain Injury, Richard R. Riker, Paige Weaver, and David J. Gagnon

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Finding the Right Scope: Dermoscopy for Primary Care, Peggy Cyr and Elizabeth Seiverling

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Impact of Dermoscopy Training for PCPs on NNB to Detect Melanoma, Madeline Prentiss, Kathryn Stevens, Henry Stoddard, Peggy Cyr, Laura Houk, Hadjh Ahrns, and Elizabeth Seiverling

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Management of rhabdomyolysis: A practice management guideline from the Eastern Association for the Surgery of Trauma, Jaswin S. Sawhney, George Kasotakis, Anna Goldenberg, Stuart Abramson, Christopher Dodgion, Nimitt Patel, Mansoor Khan, and John J. Como

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Myocarditis Following Immune Checkpoint Inhibition With Pembrolizumab: Management in a Context of Steroid Intolerance, Laura L. Onderko, Ross Heinrich, Katalin Gosling, Tim Downs, and Maxwell Eyram Afari

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Pediatric Dermatology eConsult Program with Dermoscopy: Sub Analysis of Infantile Hemangiomas, Peggy R. Cyr, Madeline Prentiss, Hadjh Ahrns, Abby Markham, and Elizabeth V Seiverling

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Woman With Groin Pain, Carrie Anne Orlikowski, Sharon Siegel, and Christina Wilson

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Society of General Internal Medicine Position Statement on Social Risk and Equity in Medicare's Mandatory Value-Based Payment Programs, Elizabeth A. Jacobs

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Metformin for treatment of cytopenias in children and young adults with Fanconi anemia, Sei-Gyung Sze

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Higher hospitalization and mortality rates among SARS-CoV-2-infected persons in rural America, Clifford J. Rosen and Susan L. Santangelo

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Mapping the time course of overt emotion dysregulation, self-injurious behavior, and aggression in psychiatrically hospitalized autistic youth: A naturalistic study, Christine B. Peura, Briana J. Taylor, and Matthew S. Siegel

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Blood Pressure Cuff Inflation Briefly Increases Adolescent Females' Restlessness During Sleep on the First but not Second Night of Ambulatory Blood Pressure Monitoring, Briana J. Taylor

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Impact of community-level socioeconomic disparities on quality of life after burn injury: A Burn Model Systems Database study, Stephanie Mason, Emma Gause, Kara McMullen, Sha'Chia Murphy, Stephen Sibbett, Radha Holavanahalli, Jeffrey Schneider, Nicole Gibran, and Lewis E. Kazis

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Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits, Clifford J. Rosen

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Management Reasoning: A Toolbox for Educators, Thilan P. Wijesekera, Andrew S. Parsons, Emily A. Abdoler, Robert Trowbridge Jr, Steven J. Durning, and Joseph J. Rencic

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Ureteroscopy with thulium fiber laser lithotripsy results in shorter operating times and large cost savings, Mitchell H. Nguyen, Joshua A. Linscott, Brian M. Jumper, Maria Ordoñez, and Johann P. Ingimarsson

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Telemedicine and the right to health: A neurosurgical perspective, Jeffrey E. Florman

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Prevalence and Predictors of Among Hospitalized Patients With Diabetic Foot Infections, Michael P. Veve, Nicholas J. Mercuro, Ryan J. Sangiovanni, Maressa Santarossa, and Nimish Patel

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Implementation of patient-reported outcomes for symptom management in oncology practice through the SIMPRO research consortium: a protocol for a pragmatic type II hybrid effectiveness-implementation multi-center cluster-randomized stepped wedge trial, Jessica Bian

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Analgesia and Sedation in Critically Ill Patients With Burns, Paige Weaver

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Factors Associated with Lower Preoperative Quality of Life in Patients with Chronic Limb Threatening Ischemia in the BEST-CLI Trial., Kristina Giles

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Thyroid Hormone Metabolism: A Historical Perspective, Arturo Hernandez

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Heart to Heart Discussions: Characterizing Goals of Care Conversations for Advanced Heart Failure Patients Initiating Palliative Inotropes, Margaret Kruithoff, Douglas Sawyer, Daria Egorova, and Rebecca N. Hutchinson

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Randomised, pragmatic, waitlist controlled trial of cannabis added to prescription opioid support on opioid dose reduction and pain in adults with chronic non-cancer pain: study protocol, Julia Jashinski, Ellie Grossman, Aurora Quaye, Corinne Cather, Kevin Potter, David A. Schoenfeld, A Eden Evins, and Jodi M. Gilman

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Early-pregnancy plasma per- and polyfluoroalkyl substance (PFAS) concentrations and hypertensive disorders of pregnancy in the Project Viva cohort, Emma V. Preston, Marie-France Hivert, Abby F. Fleisch, Antonia M. Calafat, Sharon K. Sagiv, Wei Perng, Sheryl L. Rifas-Shiman, Jorge E. Chavarro, Emily Oken, Ami R. Zota, and Tamarra James-Todd

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Shifting Tides Offer New Hope For Obesity, Clifford J. Rosen and Julie R. Ingelfinger

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3E: My Quarter Century Quest to Understand the Paradox of Marrow Adiposity, Clifford J. Rosen

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Coalescing skin-colored papules, Peggy Cyr

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Early results of geometric ring annuloplasty for bicuspid aortic valve repair during aortic aneurysm surgery, Marc W. Gerdisch, T Brett Reece, Dominic Emerson, Richard S. Downey, Geoffrey B. Blossom, Arun Singhal, Joshua N. Baker, Theodor JM Fischlein, Vinay Badhwar, Alfredo Trento, Joanna Chikwe, Lawrence M. Wei, Jason P. Glotzbach, Timothy W. James, Reed D. Quinn, J Alan Wolfe, Kentaro Yamane, Jeffrey T. Cope, Behzad Solemani, Hiroo Takayama, Victor M. Rodriguez, Takashi Murashita, Rochus K. Voeller, Ming-Sing Si, Melissa Levack, Chris R. Burke, Marc R. Moon, Alexander Kraev, Marek J. Jasinski, Georgios Stavridis, and J Scott Rankin

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Facial Plethora and Markedly Elevated Central Venous Pressure After Mitral Valve Repair, Maze, and Left Atrial Appendage Occlusion Procedures, Obieze C. Nwanna-Nzewunwa, Paul Lennon, Brian R. Gebhardt, Gregory Couper, and Michael P. Robich

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Fibrous non-union of odontoid fracture: Is it safe to accept non-operative management? A systematic review, Jeffrey E. Florman, Jakob V. Gerstl, John L. Kilgallon, and Ron I. Riesenburger

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Goal Directed Perfusion Is Not Associated with a Decrease in Acute Kidney Injury in Patients Predicted to Be at High Risk for Acute Renal Failure after Cardiac Surgery, Mark Broadwin, Monica Palmeri, Tyler Kelting, Robert Groom, Michael Robich, F Lee Lucas, and Robert Kramer

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Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321, Viswatej Avutu, Aaron R. Weiss, Damon R. Reed, Safia K. Ahmed, Wendy A. Allen-Rhoades, Yen-Lin E. Chen, Lara E. Davis, Bree R. Eaton, and Douglas S. Hawkins

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Letter to the Editor: "Midodrine to liberate ICU patients from intravenous vasopressors: Another negative fixed-dose trial"., Richard R Riker and David J Gagnon

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Predicting loss of independence after high-risk gastrointestinal abdominal surgery: Frailty vs. NSQIP risk calculator., Abdimajid Mohamed, Laura Nicolais, and Timothy L Fitzgerald

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Response: Training POCUS, David Mackenzie

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Screening for Early Emerging Mental Experiences (SEE ME): A Model to Improve Early Detection of Psychosis in Integrated Primary Care, Kristen A. Woodberry

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Stress-Related Disorders of Family Members of Patients Admitted to the Intensive Care Unit With COVID-19, Timothy Amass, Lauren Jodi Van Scoy, May Hua, Melanie Ambler, Priscilla Armstrong, Matthew R. Baldwin, Rachelle Bernacki, Mansoor D. Burhani, Jennifer Chiurco, Zara Cooper, Hope Cruse, Nicholas Csikesz, Ruth A. Engelberg, Laura D. Fonseca, Karin Halvorson, Rachel Hammer, Joanna Heywood, Sarah Hochendoner Duda, Jin Huang, Ying Jin, Laura Johnson, Masami Tabata-Kelly, Emma Kerr, Trevor Lane, Melissa Lee, Keely Likosky, Donald McGuirl, Tijana Milinic, Marc Moss, Elizabeth Nielsen, Ryan Peterson, and Sara J. Puckey

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The Psychiatric Burden on Medical Students in New York City Entering Clinical Clerkships During the COVID-19 Pandemic, Alexandra Saali, Emma R. Stanislawski, Vedika Kumar, Chi Chan, Alicia Hurtado, Robert H. Pietrzak, Dennis S. Charney, Jonathan Ripp, and Craig L. Katz

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Understanding the Effect of Bias on the Experience of Women Surgeons: A Qualitative Study, Bridget C. Olsen, Sivana L. Barron, Caitlin M. Gutheil, Elizabeth A. Blazick, Sara W. Mayo, Elizabeth N. Turner, and James F. Whiting

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Weather and prehospital predictors of trauma patient mortality in a rural American state, Obieze C. Nwanna-Nzewunwa, Carolyne Falank, Sean Francois, Julianne Ontengco, Bruce Chung, and Damien Carter

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Precision medicine and diseases as natural kinds: An epistemological dilemma, Ahti-Veikko Pietarinen and Donald E. Stanley

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Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration, Robert J. Tower, Emily Busse, Josue Jaramillo, Michelle Lacey, Kevin Hoffseth, Anyonya R. Guntur, Jennifer Simkin, and Mimi C. Sammarco

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MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass, Ellen Busschers, Naseer Ahmad, Li Sun, James R. Iben, Christopher J. Walkey, Aleksandra Rusin, Tony Yuen, Clifford J. Rosen, Ian M. Willis, Mone Zaidi, and Deborah L. Johnson

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Evaluation of the safety of a novel peripheral vasopressor pilot program and the impact on central line placement in medical and surgical intensive care units, Kristen Marti, Christopher Hartley, Elizabeth Sweeney, John Mah, and Nicholas Pugliese

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Decreased expression of ErbB2 on left ventricular epicardial cells in patients with diabetes mellitus, Joanne T. de Kay, Joshua Carver, Bailey Shevenell, Angela M. Kosta, Sergey Tsibulnikov, Emily Certo, Douglas B. Sawyer, Sergey Ryzhov, and Michael P. Robich

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Understanding the Role of Misinformation in COVID-19 Vaccine Hesitancy in a Rural State, Ann Marie Hess, Colin T. Waters, Elizabeth A. Jacobs, Kerri L. Barton, and Kathleen M. Fairfield

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Influence of circulatory shock at hospital admission on outcome after out-of-hospital cardiac arrest, Joachim Düring, Martin Annborn, Josef Dankiewicz, Allison Dupont, Sune Forsberg, Hans Friberg, Karl B. Kern, Teresa L. May, John McPherson, Nainesh Patel, David B. Seder, Pascal Stammet, Kjetil Sunde, Eldar Søreide, Susann Ullén, and Niklas Nielsen

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The International Abstract of Surgery and the migration of scientific leadership from Europe to America, David E. Clark

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Surgical Triage and Timing for Patients with COVID: A Guidance Statement from the Society of Thoracic Surgeons, Michael C. Grant, Sylvain A. Lother, Daniel T. Engelman, Ansar Hassan, Pavan Atluri, Rainer Moosdorf, J Awori Hayanga, HelenMari Merritt-Genore, Subhasis Chatterjee, Michael S. Firstenberg, Hitoshi Hirose, Jennifer Higgins, Jean-Francois Legare, Yoan Lamarche, Malek Kass, Samer Mansour, and Rakesh C. Arora

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Update on the Personal and Professional Well-Being of Surgical Residents in New England, Andrew C. Esposito, Nathan A. Coppersmith, Erin M. White, Marianna V. Papageorge, Michael DiSiena, Donald Hess, Jennifer LaFemina, Anne C. Larkin, Thomas J. Miner, Dmitry Nepomnayshy, John Palesty, Kari M. Rosenkranz, Neal E. Seymour, Gino Trevisani, James Whiting, Kristin D. Oliveira, Walter E. Longo, and Peter S. Yoo

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Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure, Kristy L. Townsend, Eleanor Pritchard, Jeannine M. Coburn, Young Mi Kwon, Magdalena Blaszkiewicz, Matthew D. Lynes, David L. Kaplan, and Yu-Hua Tseng

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Klotho in Osx-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair, Yi Fan, Chen Cui, Clifford J. Rosen, Tadatoshi Sato, Ruoshi Xu, Peiran Li, Xi Wei, Ruiye Bi, Quan Yuan, and Chenchen Zhou

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Antithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation, James V. Freeman, Angela Y. Higgins, Yongfei Wang, Chengan Du, Daniel J. Friedman, Usama A. Daimee, Karl E. Minges, Lucy Pereira, Andrew M. Goldsweig, Matthew J. Price, Vivek Y. Reddy, Douglas Gibson, Shephal K. Doshi, Paul D. Varosy, Frederick A. Masoudi, and Jeptha P. Curtis

Antithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation, James V. Freeman, Angela Y. Higgins, Yongfei Wang, Chengan Du, Daniel J. Friedman, Usama A. Daimee, Karl E. Minges, Lucy Pereira, Andrew M. Goldsweig, Matthew J. Price, Vivek Y. Reddy, Douglas Gibson, Shephal K. Doshi, Paul D. Varosy, Frederick A. Masoudi, and Jeptha P. Curtis

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Antithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation., James V Freeman, Angela Y Higgins, Yongfei Wang, Chengan Du, Daniel J Friedman, Usama A Daimee, Karl E Minges, Lucy Pereira, Andrew M Goldsweig, Matthew J Price, Vivek Y Reddy, Douglas Gibson, Shephal K Doshi, Paul D Varosy, Frederick A Masoudi, and Jeptha P Curtis

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The New England Neurosurgical Society: growth and evolution over 70 years, Andy Y. Wang, Vaishnavi Sharma, Wenya Linda Bi, William T. Curry, Jeffrey E. Florman, Michael W. Groff, Carl B. Heilman, Jennifer Hong, James Kryzanski, S Scott Lollis, Gerald T. McGillicuddy, Jennifer Moliterno, Christopher S. Ogilvy, Dennis S. Oh, Adetokunbo A. Oyelese, Mark R. Proctor, Perry A. Shear, Andrew E. Wakefield, Robert G. Whitmore, and Ron I. Riesenburger

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Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial, Julian Bösel, Wolf-Dirk Niesen, Farid Salih, Nicholas A. Morris, Jeremy T. Ragland, Bryan Gough, Hauke Schneider, Jan-Oliver Neumann, David Y. Hwang, Phani Kantamneni, Michael L. James, William D. Freeman, Venkatakrishna Rajajee, Chethan Venkatasubba Rao, Deepak Nair, Laura Benner, Jan Meis, Christina Klose, Meinhard Kieser, José I. Suarez, Silvia Schönenberger, and David B. Seder

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Management of Venous Thromboembolism in Morbid Obesity With Rivaroxaban or Warfarin, Paige Weaver, Tsz Hin Ng, Thomas Breeden, Stephanie B. Edwin, and Bradley Haan