Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2022

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Early Disseminated Lyme Disease: Cranial Neuropathy, Meningitis, and Polyradiculopathy, Tyler Crissinger and Kelly Baldwin

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Interdisciplinary Quality Improvement Project Increases Vitamin D Supplementation in Infants, Noah P. Diminick, Jamie M. Fey, Jonathan Bourque, Patricia Crosby, Leah Fox, Diana Tsai-Leonard, Heidi Morin, Kathleen Cyr, William Hewitt, and Lorraine L. McElwain

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Lyme Disease in Children, Carol A. McCarthy, Jason A. Helis, and Brian E. Daikh

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Predictors of discordant MRSA nares and respiratory cultures in patients with pneumonia, Nicholas P. Palisano, Christina F. Yen, and Nicholas J. Mercuro

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Simulation-Based Outreach Program Improves Rural Hospitals' Team Confidence in Neonatal Resuscitation, Allison Zanno, Misty Melendi, Anya Cutler, Benjamin Stone, Micheline Chipman, Jeffrey Holmes, and Alexa Craig

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Thoracoscopic-assisted rib plating (TARP): initial single-center case series, including TARP in the super elderly, technical lessons learned, and proposed expanded indications, Gary Zhang, Eric Shurtleff, Carolyne Falank, Daniel Cullinane, Damien Carter, and Forest Sheppard

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New prescription fills of selective serotonin reuptake inhibitors before and during the COVID-19 pandemic in Los Angeles County, California, Jonathan S. Levin, Joie Acosta, and Laura J. Faherty

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Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice, Adriana Lelis Carvalho, Daniel J. Brooks, Deborah Barlow, Audrie L. Langlais, Breanna Morrill, Karen L. Houseknecht, Mary L. Bouxsein, Jane B. Lian, Tamara King, Nicholas H. Farina, and Katherine J. Motyl

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Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry, Joseph Nowatzke, Paul Guedeney, Nicholas Palaskas, and Sanjeev Francis

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Real-world study of mortality after the Use of Paclitaxel-coated Devices in Peripheral Vascular Intervention, Jialin Mao, Art Sedrakyan, Philip P. Goodney, Misti Malone, Kenneth J. Cavanaugh, Danica Marinac-Dabic, Jens Eldrup-Jorgensen, and Daniel J. Bertges

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Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice, Peter C. Reifsnyder, Kevin Flurkey, Rosalinda Doty, Nigel A. Calcutt, Robert A. Koza, and David E. Harrison

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Evaluation of a pediatric dermatology electronic consult program in a rural state with subanalysis of infantile hemangioma cases, Elizabeth V. Seiverling, Madeline A. Prentiss, Laura Houk, Rachel C. Alfiero, Abby A. Markham, Mary C. Ottolini, Hadjh T. Ahrns, and Peggy R. Cyr

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American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update, Lawrence Blonde, Guillermo E. Umpierrez, Janet B. McGill, S Reddy, Sarah L. Berga, Michael Bush, Suchitra Chandrasekaran, Ralph A. DeFronzo, Daniel Einhorn, Rodica Pop-Busui, Archana R. Sadhu, Susan L. Samson, Carla Stec, William V. Tamborlane Jr, Katherine R. Tuttle, Christine Twining, Adrian Vella, Priyathama Vellanki, and Sandra L. Weber

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Genetically-biased fertilization in APOBEC1 complementation factor (A1cf) mutant mice, Naoki Hirose, Genevieve Blanchet, Yasuhiro Yamauchi, Abigail C. Snow, Robin Friedman, Carmen Y. Khoo, Christine W. Lary, Monika A. Ward, and Joseph H. Nadeau

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Clinical and psychosocial outcomes of Black Americans in the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP) study, Arundati Nagendra, David M. Weiss, Carrington Merritt, Corinne Cather, Effua E. Sosoo, Kim T. Mueser, and David L. Penn

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Utilization rate and outcomes of intravascular imaging in elderly patients presenting with ST-elevation myocardial infarction, Mohammed Elzeneini, Omkar Betageri, Sujay R. Kamisetty, Yazan Assaf, Islam Y. Elgendy, and Khanjan B. Shah

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Promoting Informed Decisions About Colorectal Cancer Screening in Older Adults (PRIMED Study): a Physician Cluster Randomized Trial, Karen Sepucha, Paul K. Han, Yuchiao Chang, Steven J. Atlas, Neil Korsen, Lauren Leavitt, Vivian Lee, Sanja Percac-Lima, Brittney Mancini, James Richter, Elizabeth Scharnetzki, Lydia C. Siegel, K D. Valentine, Kathleen M. Fairfield, and Leigh H. Simmons

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Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients: Treatment Response Rates and Value of Early Surveillance Biopsies, Fahad Aziz, Sandesh Parajuli, Margaret Jorgenson, Neetika Garg, Venkata Manchala, Elsadiq Yousif, Didier Mandelbrot, Luis Hidalgo, Maha Mohamed, Weixiong Zhong, and Arjang Djamali

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Patients' and caregivers' experiences of hospitalization under COVID-19 visitation restrictions, Anny Fenton, Sandra Stevens, Zachary Cost, Jaime Bickford, Michael Kohut, Elizabeth A. Jacobs, and Rebecca N. Hutchinson

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Cultural considerations in health care capacity building: A qualitative study in Lesotho, John Kulesa, Ian Chua, Lexi Crawford, Lineo Thahane, Jill Sanders, Mary Ottolini, and Kathy Ferrer

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Decreased expression of ErbB2 on left ventricular epicardial cells in patients with diabetes mellitus., Joanne T de Kay, Joshua Carver, Bailey Shevenell, Angela M Kosta, Sergey Tsibulnikov, Emily Certo, Douglas B Sawyer, Sergey Ryzhov, and Michael P Robich

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Family Safety Reporting in Hospitalized Children With Medical Complexity, Alexandra N. Mercer, Sangeeta Mauskar, Jennifer Baird, Jay Berry, Deanna Chieco, Katherine Copp, Elizabeth D. Cox, Helen Haskell, Karen Hennessy, Michelle M. Kelly, Nandini Mallick, Amanda McGeachey, Patrice Melvin, Tiffany Ngo, and Amy Pinkham

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High Incidence of Mechanically Assisted Crevice Corrosion at 10 Years in Non-Cemented, Non-Recalled, Contemporary Total Hip Arthroplasties, Brian J. McGrory

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Long-Term Adaptation Among Adolescent and Young Adult Children to Familial Cancer Risk, Glynnis A. McDonnell, Beth N. Peshkin, Tiffani A. DeMarco, Susan K. Peterson, Banu K. Arun, Susan Miesfeldt, Suzanne C. O'Neill, Katherine Schneider, Judy Garber, Claudine Isaacs, George Luta, and Kenneth P. Tercyak

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Management of Decompensated Cirrhosis in the Surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document, Anupamaa Seshadri, Rachel Appelbaum, Samuel P. Carmichael, Joseph Cuschieri, Jason Hoth, Krista L. Kaups, and Joseph Rappold

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Pilot Study of an Encounter Decision Aid for Lung Cancer Screening, Mayuko Ito Fukunaga, Akshu Balwan, Jaclyn A. Janis, Caitlin Gutheil, Jason Yahwak, and Paul K. Han

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Racial And Ethnic Disparities In COVID-19 Booster Uptake, Lawrence Baker, Brian Phillips, Laura J. Faherty, Jeanne S. Ringel, and Ashley M. Kranz

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Recreational Dissociation Leading to Bloody Urination, Cynthia Gaudet, Joshua Swenson, Diana Biggs, and Michelle Crispo

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The ABLE Anterior-Based Muscle-Sparing Approach: A Safe and Effective Option for Total Hip Arthroplasty, Adam J. Rana, Callahan M. Sturgeon, Brian J. McGrory, Michael V. Frazier, and George M. Babikian

Validating the Brain Injury Guidelines: Results of an American Association for the Surgery of Trauma prospective multi-institutional trial, Bellal Joseph, Omar Obaid, Linda Dultz, George Black, Marc Campbell, and Daniel Cullinane

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Woman With Cardiac Arrest, Christina Wilson, David Mackenzie, Peter Croft, John Hansen, Joshua Rehberg, and Andrew Fried

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The Role of Pharmacotherapeutic Agents in Children with Desmoid Tumors, Aaron R. Weiss

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Update and Renewal of a National Internal Medicine Curriculum for Medical Students: Process and Outcomes, Laura J. Zakowski, Nadia L. Bennett, Shobhina Chheda, Ernie Esquivel, Sara B. Fazio, Chad S. Miller, L James Nixon, and Robert Trowbridge Jr

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Cardiac Arrest Treatment Center Differences in Sedation and Analgesia Dosing During Targeted Temperature Management, Teresa L. May, David B. Seder, and Richard R. Riker

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VITAL Findings - A Decisive Verdict on Vitamin D Supplementation, Steven R. Cummings and Clifford J. Rosen

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Association of Vitamin D Prescribing and Clinical Outcomes in Adults Hospitalized with COVID-19, Kathleen M. Fairfield, Kimberly A. Murray, A Jerrod Anzalone, William Beasley, Maryam Khodaverdi, Sally L. Hodder, Jeremy Harper, Susan Santangelo, Clifford J. Rosen, and On Behalf Of The N C Consortium

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In silico discovery of blood cell macromolecular associations, Alexandra C. Hinton and Christine W. Lary

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Opioid Prescribing Patterns Before, During, and After Critical Illness: An Observational Study, Chelsea Wampole, Ariel McKenna, Richard R. Riker, Teresa L. May, David B. Seder, Dawn Abram, Gilles L. Fraser, and David J. Gagnon

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Social and maternal behavior in mesoderm specific transcript (Mest)-deficient mice, Rea P. Anunciado-Koza, J Patrizia Stohn, Arturo Hernandez, and Robert A. Koza

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The impact of the COVID-19 pandemic on people who inject drugs accessing harm reduction services in an rural American state, Kinna Thakarar, Michael Kohut, Rebecca Hutchinson, Debra Burris, and Kathleen M. Fairfield

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Correction to: Severity of traumatic adrenal injury does not meaningfully affect clinical outcomes, Bryan C. Morse

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Letermovir for Cytomegalovirus Prevention in Adolescent Patients Following Hematopoietic Cell Transplantation, Nicole P Daukshus, Anthony Cirincione, Molly Siver, Sherry Mathew, Binni Kunvarjee, Amelia Chan, Jaap Jan Boelens, Susan K. Seo, Genovefa A. Papanicolaou, and Nancy A. Kernan

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Long-Term Adaptation Among Adolescent and Young Adult Children to Familial Cancer Risk, Susan Miesfeldt

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Coronary Angiographic Findings For Out-of-Hospital Cardiac arrest Survivors Presenting With Nonshockable Rhythms and no ST Elevation Post Resuscitation, D B. Seder

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Testing and Nonpharmaceutical Interventions for Prevention of SARS-CoV-2 in 20 US Overnight Camps in Summer 2021, Laura Blaisdell, Josh Rising, André van Zyl, Julia Finn, and Jeff Vergales

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Cancers Among Adolescents and Young Adults in Maine 2001-2017: A Descriptive Analysis and Model for Future Studies, S Ashley Speckhart

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Criteria for Defining Stages of Cardiogenic Shock Severity, Andrew Schwartzman

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Innovation in Breast Surgery: Practical and Ethical Considerations, Paige Teller

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Cardiovascular disease associated with methamphetamine use: a review, Jared Tobolski, Douglas B. Sawyer, Sharon J. Song, and Maxwell Eyram Afari

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Paediatric Strategy Forum for medicinal product development of multi-targeted kinase inhibitors in bone sarcomas: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration, Aaron R. Weiss

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Syphilitic Uveitis and Alopecia, Brandon Kyle Winward

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Abnormal infant neurobehavior and later neurodevelopmental delays in children with critical CHD, Thomas A. Miller

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Case 21-2022: A 17-Year-Old Girl with Fever and Cough, Mary C. Ottolini, Randheer Shailam, Amita Sharma, and Ivy A. Rosales

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Over-the-counter alkali agents to raise urine pH and citrate excretion: a prospective crossover study in healthy adults, Johann Ingimarsson

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Serum PFAS and Urinary Phthalate Biomarker Concentrations and Bone Mineral Density in 12-19 Year Olds: 2011-2016 NHANES, Jenny L. Carwile, Shravanthi M. Seshasayee, Clifford J. Rosen, and Abby F. Fleisch

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Tranexamic acid: Beyond antifibrinolysis, Igor Prudovsky, Doreen Kacer, Victoria Vieira Zucco, Monica Palmeri, Carolyne Falank, Robert Kramer, Damien Carter, and Joseph Rappold

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Severity of traumatic adrenal injury does not meaningfully affect clinical outcomes, Jonathan Nguyen, Ndidi Ude, Nikolas Holloway, Yasmin Tootla, Krystal Archer-Arroyo, Joseph Novack, James Tran, Andrew Isaacson, and Mack Drake

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The practice and embodiment of "goofballs": A qualitative study exploring the co-injection of methamphetamines and opioids, Kinna Thakarar

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An educational intervention to facilitate appropriate subspecialty referrals: a study assessing resident communication skills, Mary Ottolini

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An educational intervention to facilitate appropriate subspecialty referrals: a study assessing resident communication skills, Mary Ottolini

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An ordinal severity scale for COVID-19 retrospective studies using Electronic Health Record data, Maryam Khodaverdi, Bradley S. Price, J Zachary Porterfield, H Timothy Bunnell, Michael T. Vest, Alfred Jerrod Anzalone, Jeremy Harper, Wes D. Kimble, Hamidreza Moradi, Brian Hendricks, Susan L. Santangelo, and Sally L. Hodder

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Drug-Eluting Stents are Associated with Superior Mid-Term Outcomes for the Treatment of Infrainguinal Bypass Graft Stenoses, Sarah E. Deery MD, MPH; Caitlin W. Hicks; David Stonko; Yasaman Kavousi; James H. Black; Ying Wei Lum; Bruce A. Perler; and Christopher J. Abularrage

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Smooth Muscle Cell Notch2 Is Not Required for Atherosclerotic Plaque Formation in ApoE Null Mice, Jessica Davis-Knowlton, Jacqueline E. Turner, Anne Harrington, and Lucy Liaw

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Female Sex Is Associated with More Reinterventions After Endovascular and Open Interventions for Intermittent Claudication, Kristina A. Giles

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Reduction and Resolution of a Hiatal Hernia Using Osteopathic Manipulative Treatment: A Case Report, Mikhail Volokitin, Anthony Song, Meredith T. Peck, and Susan Milani

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Changes in community providers' screening behaviours, referral practices, and clinical confidence following participation in an early psychosis educational campaign, Zachary B. Millman, Michelle L. West, Heather Thibeau, A Simone Sanders, Margaret Guyer, Matcheri Keshavan, Megan Lilly, Michelle Friedman-Yakoobian, Kristen A. Woodberry, Kelsey A. Johnson, and Emily R. Kline

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Comment: A Review of Pharmacologic Neurostimulant Use During Rehabilitation and Recovery After Brain Injury, Richard R. Riker, Paige Weaver, and David J. Gagnon

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Finding the Right Scope: Dermoscopy for Primary Care, Peggy Cyr and Elizabeth Seiverling

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Impact of Dermoscopy Training for PCPs on NNB to Detect Melanoma, Madeline Prentiss, Kathryn Stevens, Henry Stoddard, Peggy Cyr, Laura Houk, Hadjh Ahrns, and Elizabeth Seiverling

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Management of rhabdomyolysis: A practice management guideline from the Eastern Association for the Surgery of Trauma, Jaswin S. Sawhney, George Kasotakis, Anna Goldenberg, Stuart Abramson, Christopher Dodgion, Nimitt Patel, Mansoor Khan, and John J. Como

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Myocarditis Following Immune Checkpoint Inhibition With Pembrolizumab: Management in a Context of Steroid Intolerance, Laura L. Onderko, Ross Heinrich, Katalin Gosling, Tim Downs, and Maxwell Eyram Afari

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Pediatric Dermatology eConsult Program with Dermoscopy: Sub Analysis of Infantile Hemangiomas, Peggy R. Cyr, Madeline Prentiss, Hadjh Ahrns, Abby Markham, and Elizabeth V Seiverling

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Woman With Groin Pain, Carrie Anne Orlikowski, Sharon Siegel, and Christina Wilson

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Society of General Internal Medicine Position Statement on Social Risk and Equity in Medicare's Mandatory Value-Based Payment Programs, Elizabeth A. Jacobs

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Metformin for treatment of cytopenias in children and young adults with Fanconi anemia, Sei-Gyung Sze

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Higher hospitalization and mortality rates among SARS-CoV-2-infected persons in rural America, Clifford J. Rosen and Susan L. Santangelo

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Mapping the time course of overt emotion dysregulation, self-injurious behavior, and aggression in psychiatrically hospitalized autistic youth: A naturalistic study, Christine B. Peura, Briana J. Taylor, and Matthew S. Siegel

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Blood Pressure Cuff Inflation Briefly Increases Adolescent Females' Restlessness During Sleep on the First but not Second Night of Ambulatory Blood Pressure Monitoring, Briana J. Taylor

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Impact of community-level socioeconomic disparities on quality of life after burn injury: A Burn Model Systems Database study, Stephanie Mason, Emma Gause, Kara McMullen, Sha'Chia Murphy, Stephen Sibbett, Radha Holavanahalli, Jeffrey Schneider, Nicole Gibran, and Lewis E. Kazis

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Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits, Clifford J. Rosen

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Management Reasoning: A Toolbox for Educators, Thilan P. Wijesekera, Andrew S. Parsons, Emily A. Abdoler, Robert Trowbridge Jr, Steven J. Durning, and Joseph J. Rencic

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Ureteroscopy with thulium fiber laser lithotripsy results in shorter operating times and large cost savings, Mitchell H. Nguyen, Joshua A. Linscott, Brian M. Jumper, Maria Ordoñez, and Johann P. Ingimarsson

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Telemedicine and the right to health: A neurosurgical perspective, Jeffrey E. Florman

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Prevalence and Predictors of Among Hospitalized Patients With Diabetic Foot Infections, Michael P. Veve, Nicholas J. Mercuro, Ryan J. Sangiovanni, Maressa Santarossa, and Nimish Patel

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Implementation of patient-reported outcomes for symptom management in oncology practice through the SIMPRO research consortium: a protocol for a pragmatic type II hybrid effectiveness-implementation multi-center cluster-randomized stepped wedge trial, Jessica Bian

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Analgesia and Sedation in Critically Ill Patients With Burns, Paige Weaver

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Factors Associated with Lower Preoperative Quality of Life in Patients with Chronic Limb Threatening Ischemia in the BEST-CLI Trial., Kristina Giles

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Thyroid Hormone Metabolism: A Historical Perspective, Arturo Hernandez

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Heart to Heart Discussions: Characterizing Goals of Care Conversations for Advanced Heart Failure Patients Initiating Palliative Inotropes, Margaret Kruithoff, Douglas Sawyer, Daria Egorova, and Rebecca N. Hutchinson

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Randomised, pragmatic, waitlist controlled trial of cannabis added to prescription opioid support on opioid dose reduction and pain in adults with chronic non-cancer pain: study protocol, Julia Jashinski, Ellie Grossman, Aurora Quaye, Corinne Cather, Kevin Potter, David A. Schoenfeld, A Eden Evins, and Jodi M. Gilman

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Early-pregnancy plasma per- and polyfluoroalkyl substance (PFAS) concentrations and hypertensive disorders of pregnancy in the Project Viva cohort, Emma V. Preston, Marie-France Hivert, Abby F. Fleisch, Antonia M. Calafat, Sharon K. Sagiv, Wei Perng, Sheryl L. Rifas-Shiman, Jorge E. Chavarro, Emily Oken, Ami R. Zota, and Tamarra James-Todd

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Shifting Tides Offer New Hope For Obesity, Clifford J. Rosen and Julie R. Ingelfinger

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3E: My Quarter Century Quest to Understand the Paradox of Marrow Adiposity, Clifford J. Rosen

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Coalescing skin-colored papules, Peggy Cyr

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Early results of geometric ring annuloplasty for bicuspid aortic valve repair during aortic aneurysm surgery, Marc W. Gerdisch, T Brett Reece, Dominic Emerson, Richard S. Downey, Geoffrey B. Blossom, Arun Singhal, Joshua N. Baker, Theodor JM Fischlein, Vinay Badhwar, Alfredo Trento, Joanna Chikwe, Lawrence M. Wei, Jason P. Glotzbach, Timothy W. James, Reed D. Quinn, J Alan Wolfe, Kentaro Yamane, Jeffrey T. Cope, Behzad Solemani, Hiroo Takayama, Victor M. Rodriguez, Takashi Murashita, Rochus K. Voeller, Ming-Sing Si, Melissa Levack, Chris R. Burke, Marc R. Moon, Alexander Kraev, Marek J. Jasinski, Georgios Stavridis, and J Scott Rankin

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Facial Plethora and Markedly Elevated Central Venous Pressure After Mitral Valve Repair, Maze, and Left Atrial Appendage Occlusion Procedures, Obieze C. Nwanna-Nzewunwa, Paul Lennon, Brian R. Gebhardt, Gregory Couper, and Michael P. Robich

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Fibrous non-union of odontoid fracture: Is it safe to accept non-operative management? A systematic review, Jeffrey E. Florman, Jakob V. Gerstl, John L. Kilgallon, and Ron I. Riesenburger

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Goal Directed Perfusion Is Not Associated with a Decrease in Acute Kidney Injury in Patients Predicted to Be at High Risk for Acute Renal Failure after Cardiac Surgery, Mark Broadwin, Monica Palmeri, Tyler Kelting, Robert Groom, Michael Robich, F Lee Lucas, and Robert Kramer

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Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321, Viswatej Avutu, Aaron R. Weiss, Damon R. Reed, Safia K. Ahmed, Wendy A. Allen-Rhoades, Yen-Lin E. Chen, Lara E. Davis, Bree R. Eaton, and Douglas S. Hawkins

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Letter to the Editor: "Midodrine to liberate ICU patients from intravenous vasopressors: Another negative fixed-dose trial"., Richard R Riker and David J Gagnon