Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2024

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Transgenerational epigenetic self-memory of dosage is associated with methylation and altered growth trajectories and neonatal hormones, M Elena Martinez, Aldona Karaczyn, Zhaofei Wu, Christian A. Bennett, Kassey L. Matoin, Heather M. Daigle, and Arturo Hernandez

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Integrating an industrial hygienist into the infection prevention and control program, Angelique Dains, Spencer Baker, Takaaki Kobayashi, Stephanie Holley, Daniel Diekema, and Karen Brust

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Comparison of open and endovascular left subclavian artery revascularization for zone 2 thoracic endovascular aortic repair, Tim J. Mandigers, Sara Allievi, and Kristina Giles

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Herpes Gladiatorum in College-Aged Wrestler, Joseph M. Minichiello, TImothy Fleming, Karen Olson, Brian Malley, and Lauren Wendell

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Individualizing care for patients with gallbladder cancer, Laura M. Nicolais and Timothy Fitzgerald

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Magnitude of obesity alone does not alter the alveolar lipidome, William G. Tharp, Carolyn R. Morris, Yulica Santos-Ortega, and Calvin Vary

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Seven years of the transcarotid artery revascularization surveillance project, comparison to transfemoral stenting and endarterectomy, Sabrina Straus, Sai Divya Yadavalli, and Jens Eldrup-Jorgensen

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Platelet FcγRIIa as a Marker of Cardiovascular Risk After Myocardial Infarction, David J. Schneider, Sean R. McMahon, and Patrick Hohl

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Awake Supraglottic Airway Placement in Pediatric Patients for Airway Obstruction or Difficult Intubation: Insights From an International Airway Registry (PeDI), Mckenna Longacre, Raymond S. Park, and Jonathan Meserve

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Intravascular ultrasound in the assessment of coronary artery anomalies in young patients: a tertiary center experience, Mounica Y. Rao, Lindsay F. Eilers, and Ziyad Binsalamah

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Association of inpatient and outpatient pediatric palliative care with healthcare utilization and end-of-life outcomes in pediatric oncology, Rebecca L. Shamah and Elizabeth George

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A qualitative study of how structural vulnerability shaped COVID-19 testing behaviors in Portland, Maine, Michael Kohut PhD, Gloria Sclar, Leslie Nicoll, Caroline Fernandes, Andrew Volkers, and Ann Tucker

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Associations of ethnicity, skin tone, and genome-wide sequencing with bone mineral density in adolescents, Catherine M. Gordon, Abby F. Fleisch, Marie-France Hivert, Lisa B. Rokoff, Sheryl L. Rifas-Shiman, Jean L. Raphael, and Emily Oken

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Effects of non-pharmaceutical interventions on COVID-19 transmission: rapid review of evidence from Italy, the United States, the United Kingdom, and China, Laura J. Faherty, Pedro Nascimento de Lima, Jing Zhi Lim, Derek Roberts, Sarah Karr, and Emily Lawson

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Prevalence and Genetic Diversity of Deer Tick Virus (Powassan Virus, Lineage II) in Ixodes scapularis Ticks in Five Habitats at a Nature Reserve in Southern Maine, United States, Rebecca M. Robich, Anne Piantadosi, Susan P. Elias, Danielle S. Cosenza, Elizabeth F. Schneider, Lindsay Baxter, Erin LaFon, Charles B. Lubelczyk, Molly Meagher, Chantal B. Vogels, and Robert P. Smith

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Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress, Ekaterina D. Korobkina, Camila Martinez Calejman, John A. Haley, Miranda E. Kelly, Huawei Li, Maria Gaughan, Qingbo Chen, and Matthew D. Lynes

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Higher FSH Level Is Associated With Increased Risk Of Incident Hip Fracture In Older Adults, Independent Of Sex Hormones, Eileen H. Koh, Susan K. Ewing, Sigurdur Sigurdsson, Vilmundur Gudnason, Trisha F. Hue, Eric Vittinghoff, Claes Ohlsson, Åsa Tivesten, Louise Grahnemo, Tony Yuen, Mone Zaidi, Clifford J. Rosen, Ann V. Schwartz, and Anne L. Schafer

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Comparison of two modeling approaches for the identification of predictors of complications in children with cerebral palsy following spine surgery, Rachel L. Difazio, Tania D. Strout, Judith A. Vessey, Jay G. Berry, and Daniel G. Whitney

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Evaluating the safety and efficacy of medical management in extracranial pseudoaneurysms: a comparative study, Jean Filo, Felipe Ramirez-Velandia, Donna Lawlor, Michael Young, Samuel D. Pettersson, Thomas B. Fodor, and Robert D. Ecker

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Lowering the Carbon Footprint Through Telehealth Vasectomy Consults: A Retrospective Observational Study, Paul J. Wurtz, Emma Harwood, Thomas E. Schroeder, and Christopher M. Deibert

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Adolescent Male With Sudden, Severe Onset Right Groin Pain, Michael Hofer, Carl A. Germann, Peter Croft, and Timothy Sweeney

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Approach to Acute Dizziness/Vertigo in the Emergency Department: Selected Controversies Regarding Specialty Consultation, Madeleine M. Puissant, Susan Giampalmo, Charles R. Wira, Joshua N. Goldstein, and David E. Newman-Toker

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Challenges and Opportunities in Developing a Comprehensive, Rural, Trauma-Care Program: Experiences from Nepal, Ramu Kharel, Mandeep Pathak, Derek Lubetkin, and Bibhav Acharya

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Effect of Phenobarbital-Based Alcohol Withdrawal Protocol on Provider Practice and Patient Outcomes-A Quality Improvement Study, Nicolette Centanni, Taylor Mezoian, John Gilboy, Jessica Evans, Nicole Hudak, Wendy Craig, and Lesley Gordon

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Induction of remission after donor lymphocyte infusion following allogeneic transplant in a case of pediatric primary myelofibrosis, Amy Li, Sei-Gyung K. Sze, Malika Kapadia, Leslie Lehmann, Jacob R. Bledsoe, and Alyssa L. Kennedy

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In nondiabetic C57BL/6J mice, canagliflozin affects the skeleton in a sex- and age-dependent manner, Carolyn Chlebek, Casey McAndrews, Samantha N. Costa, Victoria E. DeMambro, Shoshana Yakar, and Clifford J. Rosen

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Library Support of Employee Engagement and Wellness, Amy Moore

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Using Longitudinal Surveillance of Unemployment Claims During Public Health Emergencies to Provide Timely and Granular Data on the Social Determinants of Health, Joie D. Acosta, Laura J. Faherty, and Margaret M. Weden

Providing Survivorship Care for a Young Adult With a History of Blood Cancer, Lauren Boehm, Nadine Linendoll, Rachel Murphy-Banks, Jenica Upshaw, In Baek, and Susan Parsons

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Development and Evaluation of a Rural Longitudinal NRP® Telesimulation Program (MOOSE: Maine Ongoing Outreach Simulation Education), Misty Melendi, Allison E. Zanno, Jeffrey Holmes, Micheline Chipman, Anya K. Cutler, Henry Stoddard, Leah Mallory, Leah M. Seften, Anna Gilbert, Mary Ottolini, and Alexa Craig

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Latest on Anabolic Agents for Osteoporosis Treatment, Luigi di Filippo and Clifford J. Rosen

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Feasibility of Fever Prevention in Vascular Brain Injury, Teresa May and Lori Shutter

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Role of patient-provider communication on older adults' preferences for continuing colorectal cancer testing and visit satisfaction, Aisha T. Langford, Kathrene Valentine, Leigh H. Simmons, Kathleen Fairfield, and Karen Sepucha

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Socioeconomic and Urban-Rural Disparities in Genome-Matched Treatment Receipt and Survival after Genomic Tumor Testing, Jessica F. DiBiase, Elizabeth Scharnetzki, Emily Edelman, E Kate Reed, Susan Miesfeldt, Cara Frankenfeld, Paul K. J. Han, and Eric C. Anderson

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Integrating Behavioral Health Into Monitoring and Surveillance During Public Health Emergencies: Challenges and Opportunities, Laura J. Faherty, Sara J. Vagi, Mary Leinhos, Robin E. Soler, and Joie D. Acosta

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Prevalent Metformin Use in Adults With Diabetes and the Incidence of Long COVID: An EHR-Based Cohort Study From the RECOVER Program, Steven G. Johnson, Sajjad Abedian, Til Stürmer, Jared D. Huling, Colby Lewis V, and Clifford J. Rosen

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Call to action: Blueprint for change in acute and critical care nursing, Martha A. Curley, Margarete L. Zalon, Maureen A. Seckel, Anne W. Alexandrov, Lauren R. Sorce, and Devin Carr

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Epigenetic Changes in the HTR8 and 3A-sub E placental Cell Lines Exposed to Bisphenol A and Benzyl Butyl Phthalate, Christian Litton, Paula Benny, Luca Lambertini, and Yula Ma

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Severe Presentations of Cannabis Toxicity in a PICU, William A. White, Michael E. Zubrow, Anya Cutler, Wendy Craig, and Jillian Gregory

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Population-based estimates of major forms of housing insecurity among community-living older Americans, Lucero G. Paredes, Yi Wang, Danya E. Keene, and Thomas Gill

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A Coproduced Family Reporting Intervention to Improve Safety Surveillance and Reduce Disparities, Alisa Khan, Jennifer Baird, Sangeeta Mauskar, Helen W. Haskell, and Amanda McGeachey

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Primary adrenal insufficiency in adults: When to suspect, how to diagnose and manage, Michelle D. Lundholm, Jayachidambaram Ambalavanan, and Pratibha Pr Rao

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Root cause analysis of cases involving diagnosis, Mark L. Graber, Gerard M. Castro, Missy Danforth, Jean-Luc Tilly, Michael P. Tozier, and Robert Trowbridge Jr

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Communicating with Parents About Therapeutic Hypothermia and Hypoxic Ischemic Encephalopathy: Integrating a Palliative Care Approach into Practice, Alexa K. Craig, Sara Munoz-Blanco, Betsy Pilon, and Monica Lemmon

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Differentiating monogenic and syndromic obesities from polygenic obesity: Assessment, diagnosis, and management, Angela K. Fitch, Sonali Malhotra, and Rushika Conroy

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Improving access to first-line treatment for pediatric obesity: Lessons from the dissemination of SmartMoves, Emily Benjamin Finn, Caroline V. Keller, Marissa A. Gowey, Mary Savoye, Stephanie Samuels, Abby F. Fleisch, and Victoria W. Rogers

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Mitigating Misinformation Toolkit: Addressing COVID-19 Misinformation Through Interprofessional Learning and Collaboration Using a Standardized Patient-Based Educational Module, Jennifer Hayman, Sara W. Nelson, Leah A. Mallory, Emily K. Dornblaser, Linda H. Chaudron, Christine Mallar, Bethany Rocheleau, Isaac Stickney, and Brendan Prast

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Perspectives on benefits and risks of creation of an "injection drug use" billing code, Gayathri Sundaram, Taisuke Sato, David Goodman-Meza, Marwan Haddad, Kinna Thakarar, Judith Feinberg, Sandra A. Springer, Kerri Barton, and Nikki Butler

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Program Signaling in Emergency Medicine: The 2022-2023 Program Director Experience, Alexis E. Pelletier-Bui, Timothy Fallon, Liza Smith, and Tania Strout

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In Support of the Decriminalization of Personal Drug and Paraphernalia Use and Possession: Position Statement of AMERSA, Inc (Association for Multidisciplinary Education, Research, Substance Use and Addiction), Katherine Hill, Katherine Dunham, Kristin Doneski, Kimberly L. Sue, and Kinna Thakarar

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Creating Optimal Clinical Learning Environments Through Interprofessional Bedside Rounding Models: Lessons From the iPACE Story, Sarah Hallen, Melissa I. Zelaya, Patti White, and Kalli Varaklis

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Network analysis of brain and bone tissue transcripts reveals shared molecular mechanisms underlying Alzheimer's Disease and related dementias (ADRD) and Osteoporosis, Archana Nagarajan, Jason Laird, Obiadada Ugochukwu, Sjur Reppe, Kaare Gautvik, Ryan D. Ross, David A. Bennett, and Clifford J. Rosen

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Recurrent pneumonia in an otherwise healthy child, Adila Abulhamail, Yanki Okuducu, Pallavi Sagar, Bernard Kinane, Ina St Onge, Anne Coates, and Benjamin A. Nelson

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Every Crisis Is an Opportunity: Advancing Blood Culture Stewardship During a Blood Culture Bottle Shortage, Jonathan H. Ryder, Trevor C. Van Schooneveld, Daniel J. Diekema, and Valeria Fabre

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Clinical Implications of New Drinking Water Regulation for "Forever Chemicals", Rachel Criswell, Abby F. Fleisch, and Alan Ducatman

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ScreenDMT reveals DiHOMEs are replicably inversely associated with BMI and stimulate adipocyte calcium influx, Jonathan M. Dreyfuss, Vera Djordjilović, Hui Pan, Valerie Bussberg, Allison M. MacDonald, Niven R. Narain, Michael A. Kiebish, Matthias Blüher, Yu-Hua Tseng, and Matthew D. Lynes

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Gastric Cancer Detection with Ensemble Learning on Digital Pathology: Use Case of Gastric Cancer on GasHisSDB Dataset, Govind Rajesh Mudavadkar, Mo Deng, Salah Mohammed Al-Heejawi, Isha Hemant Arora, Anne Breggia, Bilal Ahmad, Robert Christman, and Stephen Ryan

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Ultrasound-Guided Peripheral Intravenous Access Training: A Prospective Observational Study of Emergency Nurses., Hillary McKinley, Weeden Bauman, Erik Christensen, Peter Croft, David Mackenzie, Samantha Fillebrown, and Christina Wilson

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Pediatric subspecialty outreach clinics: reach and impact on access to care, James C. Bohnhoff, Anya Cutler, Sean Hagenbuch, and Kristen Kurland

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Hypofractionated vs Conventionally Fractionated Postmastectomy Radiation After Implant-Based Reconstruction: A Randomized Clinical Trial, Julia S. Wong, Hajime Uno, Angela C. Tramontano, Lauren Fisher, Catherine V. Pellegrini, Gregory A. Abel, Harold J. Burstein, and Matthew Cheney

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Light-responsive adipose-hypothalamus axis controls metabolic regulation, Tadataka Tsuji, Vladimir Tolstikov, Yang Zhang, Tian Lian Huang, Henrique Camara, Meghan Halpin, Niven R. Narain, King-Wai Yau, and Matthew D. Lynes

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Endothelial cells increase mesenchymal stem cell differentiation in scaffold-free 3D vascular tissue, William Gabriel DeMaria, Andre Figueroa-Milla, Abigail Kaija, Anne E. Harrington, Benjamin Tero, Larisa Ryzhova, and Lucy Liaw

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Closing the Gap: Using the ECHO Model to Improve Access to Hereditary Colorectal Cancer Risk Assessment and Genetic Counseling in the Rural Setting, Stephanie Sharp, Linda Steinmark, Emily Edelman, Kate Reed, Kelly Barnes, and Susan Miesfeldt

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Neuroendocrinology of bone, Se-Min Kim, Farhath Sultana, Funda Korkmaz, Satish Rojekar, Anusha Pallapati, Vitaly Ryu, Daria Lizneva, Tony Yuen, and Clifford J. Rosen

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Antiseizure Drugs and Pharmacogenetics-Is There Signal in the Noise?, David J. Gagnon

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Clinical features and outcomes of young patients with low-grade non-rhabdomyosarcoma soft tissue sarcomas treated with a risk-based strategy: A report from Children's Oncology Group study ARST0332, David P. Douglass, Cheryl M. Coffin, R Lor Randall, Yan Yang, Donald A. Barkauskas, Lynn Million, M Beth McCarville, Alberto S. Pappo, Aaron R. Weiss, and Sheri L. Spunt

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Comparative outcomes of open mesenteric bypass after a failed endovascular or open mesenteric revascularization for chronic mesenteric ischemia, Christopher R. Jacobs, Salvatore T. Scali, Benjamin N. Jacobs, Amanda C. Filiberto, and Kristina Giles

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Serial Shock Severity Assessment Within 72 Hours After Diagnosis: A Cardiogenic Shock Working Group Report, Van-Khue Ton, Song Li, Kevin John, Borui Li, and Andrew Schwartzman

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Appropriate and Inappropriate ICD Shocks in Patients with LVADS: Prevalence, Associated Factors, and Etiologies, Andrew Andreae, Eric Black-Maier, Kelly Arps, and Elizabeth Kobe

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Arterial hyperoxia and mortality in the cardiac intensive care unit., Jacob C Jentzer, Sean van Diepen, Carlos Alviar, P Elliott Miller, Thomas S Metkus, Bram J. Geller, and Kianoush B Kashani

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Racial Disparities in Sports Cardiology: A Review., Sheela Krishnan, James Sawalla Guseh, Merije Chukumerije, Aubrey J Grant, Peter N Dean, Jeffrey J Hsu, Mustafa Husaini, Dermot M Phelan, Ankit B Shah, Katie Stewart, Meagan M Wasfy, Quinn Capers, Utibe R Essien, Amber E Johnson, Benjamin D Levine, and Jonathan H Kim

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Reaching Structurally Vulnerable Populations Using Low-Barrier COVID-19 Testing Clinics Co-Created with Community-Based Organizations., David Ngandu, Gloria D Sclar, Ambia Ahmed, Sumayo A Awale, Caroline Fernandes, Joshua Goldstein, Hina Hashmi, Shruti Joshi, Swapnika Mallipeddi, Marie Louise Mudasigana, Leslie Nicoll, Daisy E Parker, Grace Price, Ann Tucker, Elizabeth A Vinton, Andrew Volkers, Elizabeth A Jacobs, and Kathleen Fairfield

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Viral Variants, Vaccinations, and Long Covid - New Insights., Clifford J Rosen

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Knowledge Gaps Identified in a Survey of Maine Physicians' Firearm Safety Counseling Practices., Julia Oppenheimer, Anya K. Cutler, and Kristine Pleacher MD

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Calorie Restriction in Mice Impairs Cortical but not Trabecular Peak Bone Mass by Suppressing Bone Remodeling, Linyi Liu, Phuong T. Le, J Patrizia Stohn, Hanghang Liu, Wangyang Ying, Roland Baron, and Clifford J. Rosen

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Atypical cutaneous manifestations of methicillin resistant Staphylococcus aureus infections in two immunocompetent pediatric patients: Case reports and review of the literature, Gina N. Bash, Claire Higgins, Danielle McClanahan, Rachel Dunlap, Julie Dhossche, Sabra Leitenberger, Alison Small, Stephanie Mengden Koon, and Kevin P. White

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Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC, Jozsef Gal, Calvin Vary, Carlos A. Gartner, Gregory A. Jicha, Erin L. Abner, Yulica S. Ortega, Ibrahim Choucair, Donna M. Wilcock, Ruth S. Nelson, and Peter T. Nelson

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Post-COVID-19: Hematological Factors Changes in Patients at Three-- time Intervals, Mohsen Sharifzak, Mojtaba Abbasi-Jorjandi, Gholamreza Asadikaram, Zohreh-Al-Sadat Ghoreshi, Moslem Abolhassani, and Clifford Rosen

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Identifying novel data-driven subgroups in congenital heart disease using multi-modal measures of brain structure, Marlee M. Vandewouw, Ami Norris-Brilliant, Anum Rahman, Stephania Assimopoulos, Sarah U. Morton, Azadeh Kushki, Sean Cunningham, Eileen King, Elizabeth Goldmuntz, Thomas A. Miller, and Nina H. Thomas

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Variation in Demographics, Hospital, and Patient-Reported Outcomes following Total Hip Arthroplasty According to Biological Sex, Catherine M. Call, Andrew D. Lachance, Thomas Zink, Henry Stoddard, George Babikian, Adam Rana, and Brian J. McGrory

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Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion, Anna R. Smith, Pi-I D. Lin, Sheryl L. Rifas-Shiman, Abby F. Fleisch, Robert O. Wright, Brent Coull, Patricia W. Finn, Emily Oken, Diane R. Gold, and Andres Cardenas

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Effects of a change in recall period on reporting severe symptoms: an analysis of a pragmatic multisite trial, Roshan Paudel, Andrea C. Enzinger, Hajime Uno, Christine Cronin, Sandra L. Wong, Don S. Dizon, Hannah Hazard Jenkins, Jessica Bian, Raymond U. Osarogiagbon, and Roxanne E. Jensen

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Effects of a Global Null Mutation on Murine PVAT and Cardiovascular Function, Ashley Soucy, Christian Potts, Abigail Kaija, Anne Harrington, Marissa McGilvrey, George L. Sutphin, Ron Korstanje, Benjamin Tero, Jacob Seeker, and Lucy Liaw

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Event-free survival in relapsed and refractory rhabdomyosarcoma treated on cooperative group phase II trials: A report from the Children's Oncology Group, Jonathan Metts, Wei Xue, Zhengya Gao, Sapna Oberoi, Aaron R. Weiss, and Rajkumar Venkatramani

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Improving Access to Kidney Transplant: Could Kidneys with AKI Help Narrow the Gap?, Abinet M. Aklilu and Arjang Djamali

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In Support of Overdose Prevention Centers: Position Statement of AMERSA, Inc (Association for Multidisciplinary Education and Research in Substance Use and Addiction), Katherine Dunham, Katherine Hill, Hannah Kazal, Jenna L. Butner, Ilana Hull, Kimberly Sue, and Kinna Thakarar

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Peril and Promise: Teens, Tech, and America's Mental Health Crisis, Erin Belfort, Carlene MacMillan, and Paul Weigle

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Post-operative pain control in patients on buprenorphine or methadone for opioid use disorder., Aurora Quaye, Tal Tsafnat, Janelle Richard, Henry Stoddard, and David J Gagnon

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RISE-EM: Resident Instruction in Social Emergency Medicine, a Cohort Study of a Novel Curriculum., Heidi Roche, Brandon A Knettel, Christine Knettel, Timothy S. Fallon, and Jessica Dunn

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"The Patient Is Being Pressured!" Coercion Versus Relational Autonomy, Marie-France McIntee, Laura Madigan McCown, Frank Chessa, and Rebecca N. Hutchinson

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Trainee Perspectives Regarding the Effect of the Supreme Court Decision on Obstetrics and Gynecology Training, Kate V. Meriwether, Shunaha Kim-Fine, Tova Ablove, Arthur Ollendorff, and Lindsay E. Dale

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Woman With Leg Pain, Matthew Peters, David C. Mackenzie, Christina N. Wilson, Peter E. Croft, Annie Huyler, and Margarita Popova

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Protocol modifications reduce risk of delayed pericardial effusions after vein of Marshall ethanol infusion: follow-up from the Maine experience, Jordan S. Leyton-Mange, Amanda D. Haskell, Kunal Tandon, Andrew C. Corsello, Eric Black-Maier, Edward Y. Sze, and Henry W. Sesselberg

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Morbidity Associated with Deviation from Pediatric Status Epilepticus Guidelines, Jillian Gregory, Andrew Cohen, Anya K. Cutler, and Alexa Craig

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Ensemble Deep Learning-Based Image Classification for Breast Cancer Subtype and Invasiveness Diagnosis from Whole Slide Image Histopathology, Aadhi Aadhavan Balasubramanian, Salah Mohammed Al-Heejawi, Akarsh Singh, Anne Breggia, Bilal Ahmad, Robert Christman, Stephen Ryan, and Saeed Amal

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The Plasma Metabolome and Risk of Incident Kidney Stones, Pietro Manuel Ferraro, Yukun Li, Raji Balasubramanian, Gary C. Curhan, and Eric N. Taylor

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A Systematic Review of Retracted Publications in Clinical Orthopaedic Research, Catherine M. Call, Peter C. Michalakes, Andrew D. Lachance, Thomas Zink, and Brian J. McGrory

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Enhancing the Therapeutic Activity of an Immune Checkpoint Inhibitor, MaineHealth, Peter C. Brooks, Jennifer M. Caron, and Liangru Contois

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Liposomal bupivacaine in transversus abdominis plane blocks for lower abdominal surgery, Obiyo Osuchukwu, James Gagnon, Janelle Richard, Wendy Craig, and Aurora Quaye

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Adipocytes and metabolism: Contributions to multiple myeloma, Heather Fairfield, Michelle Karam, Allyson Schimelman, Ya-Wei Qiang, and Michaela R. Reagan