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Submissions from 2017

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Distress due to prognostic uncertainty in palliative care: frequency, distribution, and outcomes among hospitalized patients with advanced cancer., Robert Gramling, Susan Stanek, Paul KJ Han, Paul Duberstein, Tim E Quill, Jennifer S Temel, Stewart C Alexander, Wendy G Anderson, Susan Ladwig, and Sally A Norton

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Is it time for goal-directed therapy in perfusion?, Robert C Groom

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Chronic neuregulin-1β treatment mitigates the progression of postmyocardial infarction heart failure in the setting of Type 1 diabetes mellitus by suppressing myocardial apoptosis, fibrosis, and key oxidant-producing enzymes., Manisha Gupte, Hind Lal, Firdos Ahmad, Douglas B Sawyer, and Michael F Hill

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Improving Cardiology Patient Flow In Nuclear Medicine, Kelly Haar, Hannah Sullivan, Kathryn Laverdiere, Nuclear Medicine Department, Haley Pelletier, Stephen Tyzik, Suneela Nayak, and Ruth Hanselman

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Using the surprise question to identify those with unmet palliative care needs in emergency and inpatient settings: what do clinicians think?, Samir A Haydar, Lisa Almeder, Lauren Michalakes, Paul K J Han, and Tania D Strout

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Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis., Samir Haydar, Matthew Spanier, Patricia Weems, Samantha Wood, and Tania Strout

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Is feedback to medical learners associated with characteristics of improved patient care?, Victoria Hayes, Robert Bing-You, Kalli Varaklis, Robert Trowbridge, Heather Kemp, and Dina McKelvy

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Is feedback to medical learners associated with characteristics of improved patient care?, Victoria Hayes, Robert Bing-You, Kalli Varaklis, Robert Trowbridge, Heather Kemp, and Dina McKelvy

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Predicting mortality of ruptured abdominal aortic aneurysms in the era of endovascular repair., Christopher T Healey, Michael Neilson, David Clark, Andres Schanzer, William Robinson, and Vascular Study Group of New England None

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How long do I have? Observational study on communication about life expectancy with advanced cancer patients., I Henselmans, E M A Smets, P K J Han, H C J C de Haes, and H W M van Laarhoven

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The evolution of uncertainty in second opinions about prostate cancer treatment., Marij A Hillen, Caitlin M Gutheil, Ellen M A Smets, Moritz Hansen, Terrence M Kungel, Tania D Strout, and Paul K J Han

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Stroke and myocardial infarction following bronchial artery embolization in a cystic fibrosis patient., Matt Hoffman, Joseph P Gerding, and Jonathan B Zuckerman

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Bone marrow adipocytes., Mark C Horowitz, Ryan Berry, Brandon Holtrup, Zachary Sebo, Tracy Nelson, Jackie A Fretz, Dieter Lindskog, Jennifer L Kaplan, Gene Ables, Matthew S Rodeheffer, and Clifford J Rosen

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Same-session bilateral ureteroscopy: safety and outcomes., Johann P Ingimarsson, Marcelino Rivera, John J Knoedler, and Amy E Krambeck

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Timeliness of access to lung cancer diagnosis and treatment: a scoping literature review., Margo M Jacobsen, Sophie C Silverstein, Michael Quinn, Leo B. Waterston, Christian A Thomas, James C Benneyan, and Paul KJ Han

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Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells., Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, and Xuehui Yang

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Determinants of follow-up failure in patients undergoing vascular surgery procedures., Dejah R Judelson, Jessica P Simons, Julie M Flahive, Virendra I Patel, Christopher T Healey, Brian W Nolan, Daniel J Bertges, and Andres Schanzer

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Human NUMB6 induces epithelial-mesenchymal transition and enhances breast cancer cells migration and Invasion., Aldona A. Karaczyn, Tamara L Adams, Robert Y S Cheng, Nicholas N Matluk, and Joseph M Verdi

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Targeting pioglitazone hydrochloride therapy after stroke or transient ischemic attack according to pretreatment risk for stroke or myocardial infarction., Walter N Kernan, Catherine M Viscoli, Jennifer L Dearborn, David M Kent, Robin Conwit, Pierre Fayad, Karen L Furie, Mark Gorman, Peter D Guarino, Silvio E Inzucchi, Amber Stuart, and Lawrence H Young

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Woman with headache and neck swelling., Randy M Kring, Heidi M Goddard, Michael T Wilmot, and Casey Z MacVane

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Woman with severe headache., Randy M Kring and David C Mackenzie

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Aligning Opioid Prescribing Pathways, Andrea Lai, Outpatient Pharmacy, Haley Pelletier, Suneela Nayak, Stephen Tyzik, and Ruth Hanselman

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Energy metabolism of the osteoblast: implications for osteoporosis., Wen-Chih Lee, Anyonya R Guntur, Fanxin Long, and Clifford J Rosen

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Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice., Phuong T Le, Kathleen A Bishop, David E Maridas, Katherine J Motyl, Daniel J Brooks, Kenichi Nagano, Roland Baron, Mary L Bouxsein, and Clifford J Rosen

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Five-year trends of critical care practice and outcomes., Craig M Lilly, Sunil Swami, Xinggang Liu, Richard R Riker, and Omar Badawi

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Blocking FSH induces thermogenic adipose tissue and reduces body fat., Peng Liu, Yaoting Ji, Tony Yuen, Elizabeth Rendina-Ruedy, Victoria E DeMambro, Samarth Dhawan, Wahid Abu-Amer, Sudeh Izadmehr, Bin Zhou, Andrew C Shin, Rauf Latif, Priyanthan Thangeswaran, Animesh Gupta, Jianhua Li, Valeria Shnayder, Samuel T Robinson, Yue Eric Yu, Xingjian Zhang, Feiran Yang, Ping Lu, Yu Zhou, Ling-Ling Zhu, Douglas J Oberlin, Terry F Davies, Michaela R Reagan, Aaron Brown, T Rajendra Kumar, Solomon Epstein, Jameel Iqbal, Narayan G Avadhani, Maria I New, Henrik Molina, Jan B van Klinken, Edward X Guo, Christoph Buettner, Shozeb Haider, Zhuan Bian, Li Sun, Clifford J Rosen, and Mone Zaidi

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Unsaturation level decreased in bone marrow fat of postmenopausal women with low bone density using high resolution magic angle spinning (HRMAS)., Xiaojuan Li, Keerthi Shet, Kaipin Xu, Juan Pablo Rodríguez, Ana María Pino, John Kurhanewicz, Ann Schwartz, and Clifford J Rosen

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Statement on gender-affirmative approach to care from the pediatric endocrine society special interest group on transgender health., Ximena Lopez, Maja Marinkovic, Toni Eimicke, Stephen M Rosenthal, and Jerrold S Olshan

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Variation in locoregional prostate cancer care and treatment trends at commission on cancer designated facilities: a national cancer data base analysis 2004 to 2013., Björn Löppenberg, Akshay Sood, Deepansh Dalela, Patrick Karabon, Jesse D Sammon, Malte W Vetterlein, Joachim Noldus, James O Peabody, Quoc-Dien Trinh, Mani Menon, and Firas Abdollah

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Congratulations, you're pregnant! Now about your shifts . . . : the state of maternity leave attitudes and culture in EM., Casey Z MacVane, Megan L Fix, Tania D Strout, Kate D Zimmerman, Rebecca B Bloch, and Christine L Hein

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The implementation of targeted temperature management: an evidence-based guideline from the Neurocritical Care Society., Lori Kennedy Madden, Michelle Hill, Teresa L May, Theresa Human, Mary McKenna Guanci, Judith Jacobi, Melissa V Moreda, and Neeraj Badjatia

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Pediatric patient-centered transitions from hospital to home: improving the discharge medication process., Leah A Mallory, Noah P Diminick, Jonathan P Bourque, Meredith R Bryden, Jessica L Miller, Nancy M Nystrom, Melanie R Lord, and Lorraine L McElwain

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Critical shoulder angle is associated with full-thickness rotator cuff tears in patients with glenohumeral osteoarthritis., Matthew T Mantell, Ryan Nelson, Jeremiah T Lowe, Donald P Endrizzi, and Andrew Jawa

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IGFBP4 is required for adipogenesis and influences the distribution of adipose depots., David E. Maridas, Victoria E. DeMambro, Phuong T. Le, Subburaman Mohan, and Clifford J. Rosen

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Adipose, bone, and myeloma: contributions from the microenvironment., Michelle M McDonald, Heather Fairfield, Carolyne Falank, and Michaela R. Reagan

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Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma., Michelle M McDonald, Michaela R Reagan, Scott E Youlten, Sindhu T Mohanty, Anja Seckinger, Rachael L Terry, Jessica A Pettitt, Marija K Simic, Tegan L Cheng, Alyson Morse, Lawrence M T Le, David Abi-Hanna, Ina Kramer, Carolyne Falank, Heather Fairfield, Irene M Ghobrial, Paul A Baldock, David G Little, Michaela Kneissel, Karin Vanderkerken, J H Duncan Bassett, Graham R Williams, Babatunde O Oyajobi, Dirk Hose, Tri G Phan, and Peter I Croucher

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Serum testosterone concentrations remain stable between injections in patients receiving subcutaneous testosterone., Julie McFarland, Wendy Craig, Nigel J Clarke, and Daniel I. Spratt

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Ultrasound gel minimizes third body debris with partial hardware removal in joint arthroplasty., Aidan C McGrory, Lee Replogle, and Donald Endrizzi

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High early major complication rate after revision for mechanically assisted crevice corrosion in metal-on-polyethylene total hip arthroplasty., Brian J McGrory and Anna H Jorgensen

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No consensus for femoral head impaction technique in surgeon education materials from orthopedic implant manufacturers., Brian J. McGrory and Eric Ng

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Elevated intra-articular cobalt and chromium levels in mechanically assisted crevice corrosion in metal-on-polyethylene total hip arthroplasty., Brian J McGrory, Abigail M Payson, and Johanna A MacKenzie

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A retrospective analysis comparing oral stepdown therapy for enterobacteriaceae bloodstream infections: fluoroquinolones versus beta-lactams., Nicholas J. Mercuro, Patricia Stogsdill, and Minkey Wungwattana

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Comparison of pre-revision magnetic resonance imaging and operative findings in mechanically assisted crevice corrosion in symptomatic metal-on-polyethylene total hip arthroplasties., Pavel P Morozov, Munib Sana, Brian J McGrory, Steven W Farraher, and Tod G Abrahams

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Stroke: a road map for subacute management., Jane G Morris, Emily L Carter, and Stephen A Martin

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Stroke: secondary prevention of ischemic events., Jane G Morris, Emily L Carter, and Stephen A Martin

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Bone marrow stroma and vascular contributions to myeloma bone homing., Michele Moschetta, Yawara Kawano, Antonio Sacco, Angelo Belotti, Rossella Ribolla, Marco Chiarini, Viviana Giustini, Diego Bertoli, Alessandra Sottini, Monica Valotti, Claudia Ghidini, Federico Serana, Michele Malagola, Luisa Imberti, Domenico Russo, Alessandro Montanelli, Giuseppe Rossi, Michaela R Reagan, Patricia Maiso, Bruno Paiva, Irene M Ghobrial, and Aldo M Roccaro

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Novel nomogram combining depth of invasion and size can accurately predict the risk for regional nodal metastases for appendiceal neuroendocrine tumors (A-NET)., Catalina Mosquera, Timothy L Fitzgerald, Haily Vora, and Marysia Grzybowski

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A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice., Katherine J Motyl, Megan Beauchemin, Deborah Barlow, Phuong T Le, Kenichi Nagano, Annika Treyball, Anisha Contractor, Roland Baron, Clifford J Rosen, and Karen L Houseknecht

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Energy metabolism of bone., Katherine J Motyl, Anyonya R Guntur, Adriana Lelis Carvalho, and Clifford J Rosen

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Screening for behavioral health conditions in primary care settings: a systematic review of the literature., Norah Mulvaney-Day, Tina Marshall, Kathryn Downey Piscopo, Neil Korsen, Sean Lynch, Lucy H Karnell, Garrett E Moran, Allen S Daniels, and Sushmita Shoma Ghose

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Improving Type And Screen Specimen Collection Prior To Elective Surgery, NorDx Blood Bank Staff, Haley Pelletier, Suneela Nayak, Stephen Tyzik, and Ruth Hanselman

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A prospective evaluation of the candle wax sign: a visual clue to diagnose aggressive basal cell carcinoma., Brian Patrick O'Donnell and Christine W Duarte

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New insights into fuel choices of nephron progenitor cells., Leif Oxburgh and Clifford J Rosen

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Identification Strategies For The Very High Fall Risk Patient In An Acute Inpatient Psychiatric Unit, P6 Inpatient Geri-Med Psychiatry, Haley Pelletier, Suneela Nayak, Stephen Tyzik, and Ruth Hanselman

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Increased utilization of cervical disk arthroplasty in university hospitals with regional variation and socioeconomic discrepancies., Sheri K Palejwala, Anand I Rughani, and Travis M Dumont

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Sensory characteristics of youth at clinical high risk for psychosis., L Diane Parham, Sean Roush, Donna T Downing, Paul G Michael, and William R McFarlane

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Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction., Tom J Parry, Anindita Ganguly, Erika L Troy, J Luis Guerrero, Jennifer F Iaci, Maya Srinivas, Andrea M Vecchione, Donald C Button, Craig S Hackett, Ronald Zolty, Douglas B Sawyer, and Anthony O Caggiano

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Cefepime-induced neurotoxicity: a systematic review., Lauren E Payne, David J Gagnon, Richard R Riker, David B Seder, Elizabeth K Glisic, Jane G Morris, and Gilles L Fraser

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Using quality improvement tools to reduce chronic lung disease., Alan Peter Picarillo and Waldemar Carlo

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A new tool to tackle the opioid epidemic: description, utility, and results from the Maine Diversion Alert Program., Brian J Piper, Clare E Desrosiers, Harriet C Fisher, Kenneth L McCall, and Stephanie D Nichols

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Healthcare policy and urologic practice., Daniel Pitts and Jesse D Sammon

Dose-Dependent and Lasting Influences of Intranasal Vasopressin on Face Processing in Men., Daniel Price, Debra Burris, Anna Cloutier, Carol B Thompson, James K Rilling, and Richmond R Thompson

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Dose-dependent and lasting influences of intranasal vasopressin on face processing in men., Daniel Price, Debra Burris, Anna Cloutier, Carol B Thompson, James K Rilling, and Richmond R Thompson

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Low bone density and bisphosphonate use and the risk of kidney stones., Megan Prochaska, Eric Taylor, Anand Vaidya, and Gary Curhan

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Patient Fall Prevention, R9 West Cardiovascular, Cathy Palleschi, Suneela Nayak, Ruth Hanselman, and Stephen Tyzik

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Emergency neurological life support: airway, ventilation, and sedation., Venkatakrishna Rajajee, Becky Riggs, and David B. Seder

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Patient-reported outcome metrics in total joint arthroplasty., Adam Rana and Shaleen Vira

The bioengineering core, Michaela Reagan

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Cover image, volume 232, number 12, December 2017., Michaela R Reagan, Jane B Lian, Clifford J Rosen, and Gary S Stein

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Clinical reasoning education at US medical schools: results from a national survey of internal medicine clerkship directors., Joseph Rencic, Robert L Trowbridge, Mark Fagan, Karen Szauter, and Steven Durning

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Intracellular lipid droplets support osteoblast function., Elizabeth Rendina-Ruedy, Anyonya R Guntur, and Clifford J Rosen

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Bone-fat interaction., Elizabeth Rendina-Ruedy and Clifford J Rosen

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Caution warranted regarding transfusion for subarachnoid hemorrhage., Richard R Riker and David B Seder

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The most important lessons I learned in training., Michael P Robich

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Real-time H2 O2 measurements in bone marrow mesenchymal stem cells (MSCs) show increased antioxidant capacity in cells from osteoporotic women., Flavia Román, Carla Urra, Omar Porras, Ana María Pino, Clifford J. Rosen, and Juan Pablo Rodríguez

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Romosozumab - promising or practice changing?, Clifford J Rosen

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The airway in inhalational injury: diagnosis and management., A Sabri, H Dabbous, A Dowli, and R Barazi

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A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation., Antonio Sacco, Yawara Kawano, Michele Moschetta, Oksana Zavidij, Daisy Huynh, Michaela Reagan, Yuji Mishima, Salomon Manier, Jihye Park, Elizabeth Morgan, Satoshi Takagi, Kwok K Wong, Ruben Carrasco, Irene M Ghobrial, and Aldo M Roccaro

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Effect of adjunct femoral endarterectomy in lower extremity bypass on perioperative and 1-year outcomes., Peter A Soden, Sara L Zettervall, Katie E Shean, Sarah E Deery, Jeffrey A Kalish, Christopher T. Healey, Nikhil Kansal, Marc L Schermerhorn, and Vascular Study Group of New England (VSGNE)

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A systematic review of transition studies of pulmonary arterial hypertension specific medications., Avraham Sofer, Michael J Ryan, Ryan J Tedford, Joel A Wirth, and Wassim H Fares

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Increased number of circulating CD8/CD26 T cells in the blood of Duchenne muscular dystrophy patients is associated with augmented binding of adenosine deaminase and higher muscular strength scores., Jonathan H Soslow, Larry W Markham, W Bryan Burnette, Cristi L Galindo, Igor Feoktistov, Frank J Raucci, Bruce M Damon, Douglas B. Sawyer, and Sergey Ryzhov

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Medical humanities: Using MedHum to promote the goal of professional identity in UME, Michael P.H. Stanley

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Higher maternal protein intake during pregnancy is associated with lower cord blood concentrations of insulin-like growth factor (IGF)-II, IGF binding protein 3, and insulin, but not IGF-I, in a cohort of women with high protein intake., Karen M Switkowski, Paul F Jacques, Aviva Must, Marie-France Hivert, Abby Fleisch, Matthew W Gillman, Sheryl Rifas-Shiman, and Emily Oken

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Adverse reaction to metal debris with concomitant incidental crystalline arthropathy in hip arthroplasty., Edward J Testa and Brian J McGrory

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Strategies To Improve Interdisciplinary Communication In An Acute Care Inpatient Pediatric Unit, Sarah Thompson; Haley Pelletier; Barbara Bush Children's Hospital-Inpatient, Maine Medical Center; Suneela Nayak; Ruth Hanselman; and Stephen Tyzik

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Guidelines for family-centered care in neuro-ICU populations: caveats for routine palliative care., Michel T Torbey, Gretchen M Brophy, Panayiotis N Varelas, Julian Bösel, Edward Manno, Mary Kay Bader, Jose I Suarez, David Seder, and W David Freeman

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Factor analysis of the scale of prodromal symptoms: data from the early detection and intervention for the prevention of psychosis program., Ivy F Tso, Stephan F Taylor, Tyler B Grove, Tara Niendam, Steven Adelsheim, Andrea Auther, Barbara Cornblatt, Cameron S Carter, Roderick Calkins, J Daniel Ragland, Tamara Sale, and William R McFarlane

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An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth., Tomoya Uchimura, Judith M Hollander, Daisy S Nakamura, Zhiyi Liu, Clifford J. Rosen, Irene Georgakoudi, and Li Zeng

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An evaluation of the opportunities for collaborative practice occurring in and the impact of interprofessional education on advanced pharmacy practice experiences., Elena M Umland, Jonathan Valenzano, Caitlin Brown, and Carolyn Giordano

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Body size and the risk of primary hyperparathyroidism in women: a cohort study., Anand Vaidya, Gary C Curhan, Julie M Paik, Molin Wang, and Eric N Taylor

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Mechanisms of marrow adiposity and its implications for skeletal health., Annegreet G Veldhuis-Vlug and Clifford J Rosen

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Impact of non-medical out-of-pocket expenses on families of children with cerebral palsy following orthopaedic surgery., Judith A Vessey, Rachel L DiFazio, Tania D Strout, and Brian D Snyder

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Adolescent female with abdominal pain., Diane Walsh, Rebecca B Bloch, and Tania D Strout

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Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature., Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, and Christine M Sorenson

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First-trimester chorionic bump--association with fetal aneuploidy in a high-risk population., Joseph R Wax, Angelina Cartin, Christian Litton, Michael G Pinette, and F L Lucas

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Cervical evaluation in pregnancy: proper measurement, evaluation, and management., Joseph R Wax, Angelina Cartin, and Michael G Pinette

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Clinical pitfalls in misoprostol-based medical management of first-trimester induced and presumed spontaneous abortion., Joseph R. Wax, Kelley Conroy, Michael G. Pinette, Christian Litton, and Angelina Cartin

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The effect of anticoagulation on bleeding-related complications following ureteroscopy., Mary E Westerman, Joseph A Scales, Vidit Sharma, Derek J Gearman, Johann P Ingimarsson, and Amy E Krambeck

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Low-dose prothrombin complex concentrate for warfarin-associated intracranial hemorrhage with INR less than 2.0., Wesley R Zemrak, Kathryn E Smith, Stephen S Rolfe, Teresa May, Robert L Trowbridge, Timothy L Hayes, Gene A Grindlinger, and David B Seder

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Cardiovascular risk in survivors of cancer., Henry Chen Zheng, Laura Onderko, and Sanjeev A Francis