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Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2022

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Pursuing Excellence: Innovations in Designing an Interprofessional Clinical Learning Environment, Cecile M. Foshee, Heather Walsh, Thomas E. Van der Kloot, Christy K. Boscardin, Laurinda Calongne, Nicole S. Telhiard, Catherine Ullman, Coleen Backus, and Sarah E. Peyre

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Speaker Introductions at Grand Rounds: Differences in Formality of Address by Gender and Specialty, Laila A. Gharzai, Kent A. Griffith, Whitney H. Beeler, Heather L. Burrows, Maya M. Hammoud, Phillip E. Rodgers, Michael S. Sabel, John M. Carethers, and Reshma Jagsi

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Sustained HIV Viral Suppression With Dolutegravir, Tenofovir, and Emtricitabine as Initial Therapy Despite High-Level Transmitted Multiclass Resistance, Ellen H. Nagami, Kinna Thakarar, and Paul E. Sax

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The health effects of vitamin D supplementation: evidence from human studies, Roger Bouillon, Despoina Manousaki, Cliff Rosen, Katerina Trajanoska, Fernando Rivadeneira, and J Brent Richards

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Variant-specific effects define the phenotypic spectrum of HNRNPH2-associated neurodevelopmental disorders in males, Hans-Jürgen Kreienkamp, Matias Wagner, Heike Weigand, Allyn McConkie-Rossell, Marie McDonald, Boris Keren, Cyril Mignot, Julie Gauthier, Jean-François Soucy, Jacques L. Michaud, Meghan Dumas, Rosemarie Smith, Ulrike Löbel, Maja Hempel, Christian Kubisch, Jonas Denecke, Philippe M. Campeau, Jennifer M. Bain, and Davor Lessel

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Pharmacokinetics of Cefazolin in Patients With Obesity Undergoing Surgery Requiring Cardiopulmonary Bypass, Justin Poltak, Christopher Connors, Minkey Wungwattana, David Nicolau, Nicholas J. Mercuro, and Jiajun Liu

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Shifting the Paradigm: A Quality Improvement Approach to Proactive Cardiac Arrest Reduction in the Pediatric Cardiac Intensive Care Unit, Christine M. Riley, J Wesley Diddle, Ashleigh Harlow, Kara Klem, Jason Patregnani, Evan Hochberg, Jenhao Jacob Cheng, Sopnil Bhattarai, Lisa Hom, Justine M. Fortkiewicz, and Darren Klugman

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Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh, Abby F. Fleisch, Sudipta Kumer Mukherjee, Subrata K. Biswas, John F. Obrycki, Sheikh Muhammad Ekramullah, D M. Arman, Joynul Islam, David C. Christiani, and Maitreyi Mazumdar

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Desperately Seeking Feedback: a phenomenographic study of medical students’ experiences during a 4-year longitudinal feedback curriculum, Robert Bing-You, Victoria Hayes, Tamara Palka, Marybeth Ford, and Robert Trowbridge

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Use of Cervid Serosurveys to Monitor Eastern Equine Encephalitis Virus Activity in Northern New England, United States, 2009-2017, John-Paul Mutebi, Abigail A. Mathewson, Susan P. Elias, Sara Robinson, Alan C. Graham, Patti Casey, and Charles B. Lubelczyk

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Carotid artery velocity time integral and corrected flow time measured by a wearable Doppler ultrasound detect stroke volume rise from simulated hemorrhage to transfusion, Jon-Émile S. Kenny, Igor Barjaktarevic, David C. Mackenzie, Mai Elfarnawany, Zhen Yang, Andrew M. Eibl, Joseph K. Eibl, Chul-Ho Kim, and Bruce D. Johnson

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Evaluating Real-World National and Regional Trends in Definitive Closure in U.S. Burn Care: A Survey of U.S. Burn Centers, Jeffrey E. Carter, Hamed Amani, Damien Carter, Kevin N. Foster, John A. Griswold, William L. Hickerson, James H. Holmes, and Samuel Jones

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Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial, Kim M. Huffman, Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, Margery A. Connelly, Carl F. Pieper, Melissa Orenduff, Leanna M. Ross, Megan E. Ramaker, James L. Dorling, Clifford J. Rosen, Irina Shalaurova, James D. Otvos, Virginia B. Kraus, and William E. Kraus

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Addressing Transportation Insecurity Improves Attendance at Posthospitalization Appointments, Sarah C. Hoffman, Amy S. Buczkowski, Leah Mallory, Lauren B. McGovern, Shannon M. Cappen, Amy S. Douglass, Russell Correia, Lee Longnecker, Campbell S. Taylor, Rebekah Holmes, Brogan Poulin, and Lorraine L. McElwain

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Addressing Transportation Insecurity Improves Attendance at Posthospitalization Appointments., Sarah C Hoffman, Amy S Buczkowski, Leah Mallory, Lauren B McGovern, and Shannon M Cappen

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Alternating bilateral Horner's syndrome during continuous thoracic epidural analgesia., Guilherme Holck and Aurora Quaye

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A Simulation Systems Testing Program Using HFMEA Methodology Can Effectively Identify and Mitigate Latent Safety Threats for a New On-Site Helipad., Jeffrey Holmes, Micheline Chipman, Tracie Barbour, Christopher DiLisio, Olivia Morejon, Erin Graydon-Baker, and Leah Mallory

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Assessing the influence of patient language preference on 30 day hospital readmission risk from home health care: A retrospective analysis, Allison Squires, Chenjuan Ma, Sarah Miner, Penny Feldman, Elizabeth A. Jacobs, and Simon A. Jones

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Bowel Dysfunction and Enteral Nutrition in Critically Ill Adult Patients: A retrospective, Observational Study, Paul A. Blakeslee, Eira Hyrkas, Erin Corica, Sonja Orff, Alana Trottier, and Elizabeth Noel Turner

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Bronchial penetration of migrated Temporary Epicardial Pacing Wire with bronchoscopic extraction, Christopher G. Roy and Nicholas A. Pozzessere

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Cell senescence and malignant transformation in the inherited bone marrow failure syndromes: Overlapping pathophysiology with therapeutic implications., Emma M Groarke, Rodrigo T Calado, and Johnson M Liu

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Community Perspectives on Social Influences on Suicide Within a Native American Reservation, Mary Cwik, S Benjamin Doty, Alexandra Hinton, Novalene Goklish, Jerreed Ivanich, Kyle Hill, Angelita Lee, Lauren Tingey, and Mariddie Craig

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Cultural considerations in health care capacity building: A qualitative study in Lesotho., John Kulesa, Ian Chua, Lexi Crawford, Lineo Thahane, Jill Sanders, Mary Ottolini, and Kathy Ferrer

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Eastern Association for the Surgery of Trauma Multicenter Trial: Comparison of pre-injury antithrombotic use and reversal strategies among severe traumatic brain injury patients, Brian K. Yorkgitis, Danielle M. Tatum, Sharven Taghavi, Thomas J. Schroeppel, Matthew R. Noorbakhsh, and Daniel Cullinane

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Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes, Neda Rasouli, Irwin G. Brodsky, Ranee Chatterjee, Sun H. Kim, Richard E. Pratley, Myrlene A. Staten, and Anastassios G. Pittas

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Hannaford Center for Safety, Innovation & Simulation 2022 Annual Report, Maine Medical Center

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Health care professional perspectives on discharging hospitalized patients with injection drug use-associated infections, Nichole Moore, Michael Kohut, Henry Stoddard, Debra Burris, Frank Chessa, Monica K. Sikka, Daniel Solomon, Colleen M. Kershaw, Ellen Eaton, Rebecca Hutchinson, Kathleen M. Fairfield, Thomas J. Stopka, Peter Friedmann, and Kinna Thakarar

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MaineHealth Institute for Research: 2022 Year in Review, MaineHealth Institute for Research

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MaineTrack 2022 Program Report for Tufts University School of Medicine & Maine Medical Center, Maine Medical Center and Tufts University School of Medicine

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Mapping Melanoma Risk and Locating High-Need Regions for Dermoscopy and Skin Biopsy Training, Calla Hladky, Madeline Prentiss, Henry Stoddard, Kathryn Stevens, Elizabeth Seiverling, and Peg Cyr

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Medication for Addiction Treatment and Postpartum Health Care Utilization Among Pregnant Persons With Opioid Use Disorder, Katherine A. Ahrens, Carole A. McBride, Alane O'Connor, and Marjorie C. Meyer

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Microclimate conditions alter Ixodes scapularis (Acari: Ixodidae) overwinter survival across climate gradients in Maine, United States, Michelle R. Volk, Charles B. Lubelczyk, Jason C. Johnston, Danielle L. Levesque, and Allison M. Gardner

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Mouse models of development and disease: Preface, Thomas Gridley and Leif Oxburgh

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Mouse mutagenesis and phenotyping to generate models of development and disease, Thomas Gridley and Stephen A. Murray

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Quantification of Lipid Area within Thermogenic Mouse Perivascular Adipose Tissue Using Standardized Image Analysis in FIJI, Benjamin W. Tero, Bethany Fortier, Ashley N. Soucy, Ginger Paquette, and Lucy Liaw

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Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study, Shizuko Akiyama, Neel Madan, George Graham, Osamu Samura, Rie Kitano, Hyuk Jin Yun, Alexa Craig, Tomohiro Nakamura, Atsushi Hozawa, Ellen Grant, Kiho Im, and Tomo Tarui

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Sexual Orientation and Age at Menarche in Three U.S. Longitudinal Cohorts, Brittany M. Charlton, Jenny L. Carwile, Jorge E. Chavarro, Amy D. DiVasta, Najat J. Ziyadeh, and S Bryn Austin

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Smad4 controls proliferation of interstitial cells in the neonatal kidney, Sarah S. McCarthy, Michele Karolak, and Leif Oxburgh

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"TEACH"ing Medical Students to Address Child Poverty: A Multimodal Curriculum, Jessica Weisz, Paula Magee, Iana Clarence, Mary Ottolini, and Olanrewaju O. Falusi

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"TEACH"ing Medical Students to Address Child Poverty: A Multimodal Curriculum., Jessica Weisz, Paula Magee, Iana Clarence, Mary Ottolini, and Olanrewaju O Falusi

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The Dangers of ACEs, Olivia Carey, Thea Forrest, and Adna Abdi

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The effect of short-term high-caloric feeding and fasting on bone microarchitecture, Miriam A. Bredella, Pouneh K. Fazeli, Jenna Bourassa, Clifford J. Rosen, Mary L. Bouxsein, Anne Klibanski, and Karen K. Miller

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The Implications of Bone Marrow Adipose Tissue on Inflammaging, Nicole Aaron, Samantha Costa, Clifford J. Rosen, and Li Qiang

Submissions from 2021

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Heterozygous Truncating Mutation of Nucleolin in an ASD Individual Disrupts Its Nucleolar Localization, Taimoor I. Sheikh, Ricardo Harripaul, Nasim Vasli, Majid Ghadami, Susan L. Santangelo, Muhammad Ayub, Roksana Sasanfar, and John B. Vincent

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Hispanic/Latino-Serving Hospitals Provide Less Targeted Temperature Management Following Out-of-Hospital Cardiac Arrest, Nicholas A. Morris, Michael Mazzeffi, Patrick McArdle, Teresa L. May, Greer Waldrop, Sarah M. Perman, James F. Burke, and Steven M. Bradley

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Vascular Quality Initiative Surveillance of Femoropopliteal Artery Paclitaxel Devices, Daniel J. Bertges, Jens Eldrup-Jorgensen, Susan Robbins, Henry Ssemaganda, Misti Malone, Danica Marinac-Dabic, Joshua Smale, Aaron E. Lottes, Arjun Majithia, and Frederic S. Resnic

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"Sick or not sick?" A mixed methods study evaluating the rapid determination of illness severity in a pediatric emergency department., Laura B O'Neill, Priti Bhansali, James E Bost, James M Chamberlain, and Mary C Ottolini

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Emotional and stigma-related experiences relative to being told one is at risk for psychosis, Kristen A. Woodberry, Kate S. Powers, Caitlin Bryant, Donna Downing, Mary B. Verdi, Katherine M. Elacqua, Audrey R. Reuman, and Leda Kennedy

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Family planning in carriers of BRCA1 and BRCA2 pathogenic variants, Jessica M. Haddad, Katina Robison, Lindsey Beffa, Jessica Laprise, Jennifer ScaliaWilbur, Christina A. Raker, Melissa A. Clark, and Erin Hofstatter

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DEspR neutrophils are associated with critical illness in COVID-19, Joanne T. deKay, Ivette F. Emery, Jonathan Rud, Ashley Eldridge, Christine Lord, David J. Gagnon, and Teresa L. May

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Emphasizing the Link Between Human Health and the Environment in Residency Education., Lesley B. Gordon and Katherine Liu

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Management of blunt traumatic abdominal wall hernias: A Western Trauma Association multicenter study, Kevin N. Harrell, Arthur D. Grimes, Roxie M. Albrecht, Jessica K. Reynolds, Walker R. Ueland, Daniel Cullinane, and Carolyne Falank

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Prescription opioid policies and associations with opioid overdose and related adverse effects, Valerie S. Harder, Susan E. Varni, Kimberly A. Murray, Timothy B. Plante, Andrea C. Villanti, Daniel L. Wolfson, and Sanchit Maruti

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Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing., Jenny L Carwile, Shravanthi M Seshasayee, Izzuddin M Aris, Sheryl L Rifas-Shiman, Birgit Claus Henn, Antonia M Calafat, Sharon K Sagiv, Emily Oken, and Abby F Fleisch

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Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice, Mélanie H. Thomas, Yujuan Gui, Pierre Garcia, Mona Karout, Borja Gomez Ramos, Christian Jaeger, Alessandro Michelucci, and Anthoula Gaigneaux

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The Future Nephrology Workforce: There Will Be One, Mark G. Parker and Stephen M. Sozio

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Leveraging Improvement Capacity for Organization Strategy Deployment, Suneela Nayak, Natalia Johnson, Rebecca A. Brookes, and Andrew Levine

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Pandemic Pearl: Innovations in Virtual Improvement Coaching, Suneela Nayak, Natalia Johnson, Rebecca Brookes, and Andrew Levine

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Supporting an Advanced Practice Provider (APP) Residency Program, Dina McKelvy

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Myocarditis in the Setting of Recent COVID-19 Vaccination., Laura Onderko, Benjamin Starobin, Amy E Riviere, Patrick K Hohl, Colin T Phillips, Roisin B Morgan, Aimee Welsh, Sanjeev A Francis, and Maxwell Eyram Afari

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Evaluating Health Economic Outcomes of Autologous Skin Cell Suspension for Definitive Closure in US Burn Care Using Contemporary Real-World Burn Center Data, K Foster, A Amani, Damien Carter, J Griswold, and B Hickerson

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Factorial Analysis Quantifies the Effects of Pediatric Discharge Bundle on Hospital Readmission., Snezana Nena Osorio, Sandra Gage, Leah Mallory, Paula Soung, Alexandra Satty, Erika L Abramson, Lloyd Provost, and David Cooperberg

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Supporting families in their child's journey with neonatal encephalopathy and therapeutic hypothermia, Betsy Pilon, Alexa K. Craig, Monica E. Lemmon, and Annie Goeller

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Urinary stone disease prevalence and associations in cystic fibrosis., Jeremy F Wright, Wendy Craig, F L Lucas, David S Goldfarb, Jonathan B Zuckerman, and Eric N Taylor

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Training in neonatal neurocritical care: a proposal for a hybrid model of competence by design and time-based methods., Khorshid Mohammad, Alexa K Craig, Taeun Chang, Emily W Y Tam, Mariam Ayed, Linda S de Vries, Mohamed A El-Dib, Michael J Esser, Donna M Ferriero, Lena Hellström-Westas, Steven P Miller, Janet S Soul, Brigitte Vollmer, Hannah C Glass, and Christopher D Smyser

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How Well Does the Surprise Question Predict 1-year Mortality for Patients Admitted with COPD?, Dana Tripp, Jaclyn Janis, Benjamin Jarrett, F Lee Lucas, Tania D. Stout, Paul K J Han, Isabella Stumpf, and Rebecca N. Hutchinson

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Notch1 and Notch2 collaboratively maintain radial glial cells in mouse neurogenesis, Shun Mase, Atsunori Shitamukai, Quan Wu, Mitsuru Morimoto, Thomas Gridley, and Fumio Matsuzaki

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A Cystic Renal Mass in the Setting of a Pneumothorax: More Than Meets the Eye?, Daniel S. Han, David J. Chalmers, Brian Greffe, Timothy Garrington, David Partrick, Mark Lovell, Kami Wolfe Schneider, and Nicholas G. Cost

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The influence of uncertainty and uncertainty tolerance on attitudes and self-efficacy about genomic tumor testing, Eric C. Anderson, Alexandra Hinton, Christine W. Lary, Tania Strout, Andrey Antov, Emily Edelman, Petra Helbig, Kate Reed, Jens Rueter, and Paul K. Han

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Management of Minor Traumatic Brain Injury in an ED Observation Unit, Matthew A. Wheatley, Shikha Kapil, Amanda Lewis, Jessica Walsh O'Sullivan, Joshua Armentrout, Tim P. Moran, Anwar Osborne, Brooks L. Moore, Bryan Morse, Peter Rhee, Faiz Ahmad, and Hany Atallah

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Decreasing Unplanned Extubations in the Neonatal ICU, Deborah A. Igo, Kimberly Kingsley, Elisabeth Malaspina, and Alan Picarillo

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Influence of Opioid Prescription Policy on Overdoses and Related Adverse Effects in a Primary Care Population, Valerie S. Harder, Timothy B. Plante, Insu Koh, Ethan B. Rogers, Susan E. Varni, Andrea C. Villanti, John R. Brooklyn, and Kathleen Fairfield

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Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study, Zachary A. Matthay, Zane J. Hellmann, Rachael A. Callcut, Ellicott C. Matthay, Brenda Nunez-Garcia, Daniel Cullinane, and Julianne Ontengco

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Patient and family perceptions of an inpatient journal, Marguerite Peggy Anderson and Kristiina Hyrkas

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Patients over 65 years with Acute Complicated Calculous Biliary Disease are Treated Differently-Results and Insights from the ESTES Snapshot Audit, Gary A. Bass, Amy E. Gillis, Yang Cao, Shahin Mohseni, and Daniel Cullinane

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Transdiaphragmatic Chest Wall Herniation, Anna G. Meader, David L. Ciraulo, Joseph F. Rappold, and Jaswin S. Sawhney

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Treating the endotheliopathy of SARS-CoV-2 infection with plasma: Lessons learned from optimized trauma resuscitation with blood products, Shibani Pati, Erin Fennern, John B. Holcomb, Mark Barry, Alpa Trivedi, and Joseph Rappold

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Young Man with Swollen Knee., Nicholas Fling and Andrew Fried

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Can hospital adult code-teams and individual members perform high-quality CPR? A multicenter simulation-based study incorporating an educational intervention with CPR feedback, Jesse M. Rideout, Edwin Ozawa, Darlene Bourgeois, Micheline Chipman, and Frank Overly

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Computer-aided learning for managing stress: A feasibility trial with clinical high risk adolescents and young adults, Kristen A. Woodberry, Cole Chokran, Kelsey A. Johnson, Keith H. Nuechterlein, David J. Miklowitz, Stephen V. Faraone, and Larry J. Seidman

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Poststent ballooning during transcarotid artery revascularization, Hanaa Dakour-Aridi, Christina L. Cui, Andrew Barleben, Marc L. Schermerhorn, Jens Eldrup-Jorgensen, and Mahmoud B. Malas

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Severity and patterns of injury in helmeted vs. non-helmeted motorcyclists in a rural state, Sivana Barron, Carolyne Falank, Julianne Ontengco, Bruce Chung, and Damien Carter

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The Value of Adapting Clinical Reasoning Teaching Methods, Devin Carr

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Management of simple and retained hemothorax: A practice management guideline from the Eastern Association for the Surgery of Trauma, Nimitt J. Patel, Linda Dultz, Husayn A. Ladhani, Daniel C. Cullinane, and Eric Klein

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Physical Therapy, Occupational Therapy, and Speech Language Pathology in the Emergency Department: Specialty Consult Services to Enhance the Care of Older Adults, Elizabeth Pontius and Rob Anderson

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Third trimester maternal vitamin D and early childhood socioemotional development, Ellen C. Francis, Elizabeth Charron, Mengying Li, Liwei Chen, Rachel Mayo, Linda S. Butler, and Lior Rennert

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Roundtable on Preseason Heat Safety in Secondary School Athletics: Prehospital Care of Patients With Exertional Heat Stroke., Kevin C Miller, Douglas J Casa, William M Adams, Yuri Hosokawa, Jason Cates, Christina Emrich, Tony Fitzpatrick, Michael Hopper, John F Jardine, Michele LaBotz, Rebecca M Lopez, Francis O'Connor, and M Seth Smith

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Physical Examination is Inadequate to Rule Out Thoracolumbar Spine Injuries in a Rural Trauma Center, Scha'Chia Murphy, Rosemary Elizabeth Paine, Carolyne Falank, Julianne Ontengco, Forest Sheppard, and Damien Carter

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Electrically Controllable Surgical Tools, Robert D. Ecker and Mohsen Shahinpoor

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Distance Learning and Spaced Review to Complement Dermoscopy Training for Primary Care., Elizabeth V Seiverling, Danielle Li, Kathryn Stevens, Peggy Cyr, Gregory Dorr, and Hadjh Ahrns

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Corrigendum to "Maternal opioid use disorder at delivery hospitalization in a rural state: Maine, 2009-2018" [Public Health 181C (2020) 171-179]., Sarah M. Gabrielson, J L Carwile, A B O'Connor, and K A Ahrens

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End-of-Life Care: Improving Communication and Reducing Stress, Joan Carr Myers and Kristiina Hyrkas

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Medical student perspectives on conducting patient experience debrief interviews with hospitalized children and their families, Ian S. Chua, Alyssa L. Bogetz, Michele Long, Terry Kind, Mary Ottolini, Matthew Lineberry, and Priti Bhansali

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FOXD1 regulates cell division in clear cell renal cell carcinoma, Kyle H. Bond, Jennifer L. Fetting, Christine W. Lary, Ivette F. Emery, and Leif Oxburgh

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Efficacy of Sex Steroid Therapy Without Progestin or GnRH Agonist for Gonadal Suppression in Adult Transgender Patients., India I Pappas, Wendy Craig, Lindsey V Spratt, and Daniel I Spratt

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Case Report of Cardiopulmonary Arrest During Pregnancy due to Opioid Overdose, Tracey E. McMillan, Sarah Austin, and Kristiina Hyrkas

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Increasing intraoperative hydromorphone does not decrease postoperative pain: a retrospective observational study., Craig S Curry, Wendy Craig, Janelle M Richard, and Denham S Ward

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Multicystic Dysplastic Kidney With Mass Effect in a Neonate Treated With Nephrectomy: Case Report, Samuel M. Pettit, William J. Devan, David J. Chalmers, and Allison Zanno

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Pediatric Hospitalists' Performance and Perceptions of Script Concordance Testing for Self-Assessment, Mary C. Ottolini, Ian Chua, Joyce Campbell, Martin Ottolini, and Ellen Goldman

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Per- and polyfluoroalkyl substance plasma concentrations and metabolomic markers of type 2 diabetes in the Diabetes Prevention Program trial, Susanna D. Mitro, Jinxi Liu, Lindsay M. Jaacks, Abby F. Fleisch, Paige L. Williams, William C. Knowler, Blandine Laferrère, Wei Perng, George A. Bray, Amisha Wallia, Marie-France Hivert, Emily Oken, Tamarra M. James-Todd, and Marinella Temprosa