Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. MaineHealth Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2020

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Evaluating Efficacy of a Recently Implemented Malnutrition Screening Tool, Rebecca Edwards and Paul Blakeslee

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Evaluation of a Resident-Driven Trauma-Sensitive Yoga Program for Female Immigrant Primary Care Patients, Katherine Rizzolo, Maha Jaber, Jessica Schaumburg, Kiana Vakil-Gilani, and Nicole Rebusi

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Evidence based estimation of energy and protein needs in adults with major burn injuries, Ashley Lazarz and Samantha Buttarazzi Waller

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Exploring Patient Activation in the Emergency Department at Maine Medical Center, Rushi Shaw, Samir Haydar, Tania Strout, and Karla Hyde

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Factors correlating with interprofessional engagement in debriefing following pediatric simulation-based team training., Richard Byrnes, Zachary Priest, Christine Schreiber, Justin Michaud, Tracie Barbour, Michael Ferguson, Micheline Chipman, Wendy Craig, and Leah Mallory

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Hospital birth volume impacts resuscitation and outcomes of infants after therapeutic hypothermia, Prathusha Yerramilli, Channing Pooley, Nabeel Hashmi, Jay Kerecman, Misty Melendi, and Alexa Craig

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Impact of Sleep on Mood & Psychotic Symptoms in Early & Emerging Psychosis, K Penner Coxon, K A. Johnson, K Powers, K Elacqua, W L. Cook, R I. Mesholam-Gately, and K A. Woodberry

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Implementation of CRISPR/Cas editing analysis tool ICE to detect multiple edited alleles in mice, Larisa Ryzhova, Anne Harrington, Samantha White, and Lucy Liaw

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Improving vitamin D management in an adult cystic fibrosis program., Stefanie DiLoretor, Alicia Murry, Tegan Smith, and Lauren Tate

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Innovations at MaineHealth-Introduction, Susan Ahern

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Insulin-like Growth Factor Binding Protein 2 May Promote Bone Loss After Vertical Sleeve Gastrectomy: A Pilot Study and Preliminary Data, A N. Pletch, B Harris, P T. Le, and Clifford Rosen

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Investigating the Effect that Inhibiting Fatty Acid Binding Proteins 4 or 5 Have on Myeloma Cell Proliferation, Anastasia D’Amico, Mariah Farrell, and Michaela Reagan

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Irisin Stimulates Osteoclast Differentiation and Function, Eben Estell, Phuong Le, Yosta Vegting, Hyeonwoo Kim, Roland Baron, Bruce Spiegelman, and Clifford Rosen

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Lean Phenotype Induced by Methionine Restriction in Mice is Associated with Proteomic Changes in Perivascular Adipose Tissue, Bethany H. Fortier, Calvin PH Vary, Robert A. Koza, Gene P. Ables, and Lucy Liaw

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Loss of vitamin A stores impairs cardiac workload and function under stress conditions, Amanda J. Favreau‐Lessard, MaryAnn Asson‐Batres, Douglas B. Sawyer, and Ilka Pinz

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MaineHealth Innovation COVID-19 Successes, Susan Ahern

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MMC Biobank: A resource for translational research., Anne C. Breggia, Sue LaPierre, Christopher Keister, Hanna Renedo, Dawn Charnetzky, Hannah Brown, Howard Feller, Susan Nester, Robert Christman, Michael Jones, Tony Sellner, Liz Hamir, Lindsay Cote, and Heidi Ingersoll

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Notch signaling regulates perivascular adipose tissue (PVAT) function during diet-induced obesity, Chenhao Yang, Joshua M. Boucher, Larisa M. Ryzhova, and Lucy Liaw

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Opening Remarks - Costas T. Lambrew Research Retreat 2020, Douglas Sawyer

Patients’ expectations of the benefits of large-panel genomic tumor testing, Eric Anderson, John DiPalazzo, and Paul Han

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Pharmacogenetic and MicroRNA Effects of Beta Blocker Association with Increased Bone Mineral Density in Humans, Kathleen T. Nevola, Douglas P. Kiel, Andrew R. Zullo, Ines Foessl, Barbara Obermayer-Pietsch, Katherine Motyl, and Christine W. Lary

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Population and hospitalization characteristics of patients served by the Preble Street Learning Collaborative (PSLC) who leave the hospital with self-directed discharge, Hannah Martin, Emily Zarookia, Adam Normandin, Kathleen Fairfield, Wendy Craig, and Debra Rothenberg

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Predicting Polymicrobial Stone in Patients Undergoing PCNL, William Daly, Erin Santos, Christopher Stockdale, and Johann Ingimarsson

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Primary cilia-mediated ventricular maturation in congenital heart disease: A role for ErbB signaling?, Lindsey A. Fitzsimmons, Sergey Ryzhov, and Kerry L. Tucker

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Prrx1-CreAlplfl/flmice, a model for further investigations into the pathophysiological changes in Hypophosphatemia, Victoria DeMambro, Jennifer Daruszka, Daniel Brooks, Mary Bouxsein, and Cliff Rosen

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Reliability and Criterion Validity of Ultrasonic Measurements of the Supraspinatus and Infraspinatus Cross-Sectional Area, Dirk Kokmeyer, Lori-Thein Brody, Shane Koppenhaver, and Charles Thigpen

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Role of Zfp467in Mediating the Anti-Adipogenic and Pro-Osteogenic Effects of PTH: An In-VitroAnalysis, H Liu, I Leon Calle, P T. Le, R Baron, and C J. Rosen

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Rural harm reduction access and regional trends., Kinna Thakarar

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Sclerostin antibody normalizes decreased trabecular bone and increased bone marrow adipose tissue caused by whole-body irradiation in mice, Samantha Costa, Heather Fairfield, Mariah Farrell, Connor Murphy, Ashley Soucy, Gill Holdsworth, and Michaela R. Reagan

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Stigmatizing Attitudes Towards People who Smoke: A Survey of Primary Care Physicians, Liz Scharnetzki, Leo B. Waterston, Susan E. Leeds, Jamie L. Studts, Neil Korsen, and Paul K J Han

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Study Strategies for General Surgery Residents Preparing for the ABSITE: What to Keep, Discard, and Adopt, A Pletch, Wendy Craig, J Rappold, J Whitting, and C Turner

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Targeting bone marrow adipose tissue and the FABP family increases efficacy of dexamethasone in MM, Mariah Farrell, Heather Fairfield, Carolyne Falank, Samantha Costa, Anastasia D’Amico, Dominic Bowers, and Michaela R. Reagan

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Testosterone (T) and estradiol (E2) therapy alone can suppress gonadal function in transgender patients., India I. Pappas, Wendy Craig, Lindsey V. Spratt, and Daniel I. Spratt

The clinical significance of molecular subtyping in glioblastoma, Wendy Craig, Rebecca Bystrom, Jens Rueter, and Christine Lu-Emerson

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The dynamics of human bone marrow adipose tissue in response to feeding and fasting, Gisela Pachón-­Peña, Pouneh K. Fazeli, Miriam A. Bredella, Elizabeth K. O’Donell, Anne Klibanski, and Clifford J. Rosen

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The Impact of an InterprofessionalEducation Curriculum on Medical, Pharmacy and Social Work Students’ Interdisciplinary Perceptions and Teamwork, Victoria Hayes, Corinn Martineau, Julie Schirmer, and Peggy Cyr

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The myokine irisin stimulates osteoclast differentiation and function, Eben G. Estell, P T. Le, Y Vegting, H Kim, R Baron, B Speigelman, and C J. Rosen

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The Role of Smooth Muscle Cell Notch2 in Atherosclerotic Plaque Burden and Composition, Jess Davis-Knowlton, Jackie Turner, Anne Harrington, and Lucy Liaw

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Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression, Virginia Lee

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Dysphagia After Cardiopulmonary Resuscitation: A Case of Aspirated Dentures., Elizabeth J Hamilton, Casey MacVane, and Tania D Strout

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The Effect of Prognostic Communication on Patient Outcomes in Palliative Cancer Care: a Systematic Review, Naomi C. van der Velden, Maartje C. Meijers, Paul K. J. Han, Hanneke W. van Laarhoven, Ellen M. Smets, and Inge Henselmans

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Tuberculosis and foreign-born populations in the United States: A mixed methods pilot study of media reporting and political identification, Angel N. Desai, Shravanthi M. Seshasayee, Maimuna S. Majumder, Britta Lassmann, Lawrence C. Madoff, Emily L. Cohn, and John S. Brownstein

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Coronary Artery Disease Assessed by Computed Tomography-Based Leaman Score in Patients With Low-Risk Transcatheter Aortic Valve Implantation., Yuichi Ozaki, Hector M Garcia-Garcia, Toby Rogers, Rebecca Torguson, Paige E Craig, Alexandre Hideo-Kajita, Paul Gordon, Afshin Ehsan, Puja Parikh, Thomas Bilfinger, David Butzel, Scott Buchanan, Robert Levitt, Chiwon Hahn, Maurice Buchbinder, Nicholas Hanna, Robert Garrett, Sean R Wilson, John A Goncalves, Syed Ali, Federico M Asch, Gaby Weissman, Christian Shults, Itsik Ben-Dor, Lowell F Satler, and Ron Waksman

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Calling the Shots? Adolescents' Influence on Human Papillomavirus Vaccine Decision-Making During Clinical Encounters., Anny T H R Fenton, Terresa J Eun, Jack A Clark, and Rebecca B Perkins

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Code Blue in the COVID-19 Patient, Jeffrey A. Holmes

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Critical Assessment of In Vitro and In Vivo Models to Study Marrow Adipose Tissue., Michaela R Reagan

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Dietary characteristics associated with plasma concentrations of per- and polyfluoroalkyl substances among adults with pre-diabetes: Cross-sectional results from the Diabetes Prevention Program Trial., Pi-I D Lin, Andres Cardenas, Russ Hauser, Diane R Gold, Ken P Kleinman, Marie-France Hivert, Abby F Fleisch, Antonia M Calafat, Marco Sanchez-Guerra, Citlalli Osorio-Yáñez, Thomas F Webster, Edward S Horton, and Emily Oken

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Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice., Gang Xi, Victoria E Demambro, Susan D'Costa, Shalier K Xia, Zach C Cox, Clifford J Rosen, and David R Clemmons

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Evidence-Based Education for Perianesthesia RNs to Increase Knowledge and Change Attitudes of Electroconvulsive Therapy., Lois M Hayworth and Kristiina E Hyrkas

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GSK-3: An important kinase in colon and pancreatic cancers., Roberto J Vidri and Timothy L Fitzgerald

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Imaging the Placental Cord Insertion: Just Do It., Joseph R Wax and Michael G Pinette

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Infective Endocarditis During the Infectious Diseases and Substance Use Disorder Syndemic: A Six-Year Case Series, N P. Sankar, K Thakarar, and Kristina E. Rokas

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Integrating Screening, Brief Intervention and Referral to Treatment (SBIRT) for Substance Use into Prenatal Care., Jean C Hostage, Julia Brock, Wendy Craig, and Debra Sepulveda

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Letter to the Editor on "Cobalt and Chromium Ion Release in Metal-on-Polyethylene and Ceramic-on-Polyethylene THA: A Simulator Study With Cellular and Microbiological Correlations"., Brian J McGrory

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Maternal opioid use disorder at delivery hospitalization in a rural state: Maine, 2009-2018., Sarah M. Gabrielson, J L Carwile, A B O'Connor, and K A Ahrens

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Mortality in infantile spasms: A hospital-based study., Chellamani Harini, Elanagan Nagarajan, Ann M Bergin, Phillip Pearl, Tobias Loddenkemper, Masanori Takeoka, Peter F Morrison, David Coulter, Gita Harappanahally, Candice Marti, Kanwaljit Singh, Christopher Yuskaitis, Annapurna Poduri, and Mark H Libenson

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Neurodevelopmental Outcomes of Neonates Randomized to Morphine or Methadone for Treatment of Neonatal Abstinence Syndrome., Adam J Czynski, Jonathan M Davis, Lynne M Dansereau, Barbara Engelhardt, Peter Marro, Debra L Bogen, Mark L Hudak, Jeffrey Shenberger, Elisha M Wachman, Erica L Oliveira, and Barry M Lester

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Outcomes of carotid endarterectomy in the Vascular Quality Initiative based on patch type., Leia Edenfield, Elizabeth Blazick, Jens Eldrup-Jorgensen, Christopher Healey, Paul Bloch, Robert Hawkins, Nathan Aranson, and Brian Nolan

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Phospho-proteomic discovery of novel signal transducers including thioredoxin-interacting protein as mediators of erythropoietin-dependent human erythropoiesis., Matthew A Held, Emily Greenfest-Allen, Edward Jachimowicz, Christian J Stoeckert, Matthew P Stokes, Antony W Wood, and Don M Wojchowski

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Protocoled thrombolytic therapy for frostbite improves phalangeal salvage rates., Rosemary Elizabeth Paine, Elizabeth Noel Turner, Daniel Kloda, Carolyne Falank, Bruce Chung, and Damien Carter

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Weight Management in Primary Care for Children With Autism: Expert Recommendations., Carol Curtin, Susan L Hyman, Diane D Boas, Sandra Hassink, Sarabeth Broder-Fingert, Lauren T Ptomey, Meredith Dreyer Gillette, Richard K Fleming, Aviva Must, and Linda G Bandini

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Feasibility of Coronary Access and Aortic Valve Reintervention in Low-Risk TAVR Patients., Toby Rogers, Benjamin C Greenspun, Gaby Weissman, Rebecca Torguson, Paige Craig, Christian Shults, Paul Gordon, Afshin Ehsan, Sean R Wilson, John Goncalves, Robert Levitt, Chiwon Hahn, Puja Parikh, Thomas Bilfinger, David Butzel, Scott Buchanan, Nicholas Hanna, Robert Garrett, Maurice Buchbinder, Federico Asch, Hector M Garcia-Garcia, Petros Okubagzi, Itsik Ben-Dor, Lowell F Satler, and Ron Waksman

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Area Deprivation Index and Rurality in Relation to Lung Cancer Prevalence and Mortality in a Rural State., Kathleen M Fairfield, Adam W Black, Erika C Ziller, Kimberly Murray, F Lee Lucas, Leo B Waterston, Neil Korsen, Darlene Ineza, and Paul K J Han

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Acute Kidney Recovery in Patients Who Underwent Transcatheter Versus Surgical Aortic Valve Replacement (from the Northern New England Cardiovascular Disease Study Group)., Rony Lahoud, David W Butzel, Anahita Parsee, Yi-Ling Huang, Richard J Solomon, James T DeVries, James M Flynn, Alexander Iribarne, Peter Ver Lee, Cathy S Ross, David J Malenka, and Harold L Dauerman

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Brown adipocytes from induced pluripotent stem cells-how far have we come?, Aaron C Brown

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Catheter-Directed Thrombolysis With Ultrasound Assistance for Acute Pulmonary Embolism: Time to Curb the Enthusiasm?, Srinath Adusumalli, Bram Geller, and Jay Giri

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Childhood hair cortisol concentration and early teen cardiometabolic outcomes., Joshua Petimar, Sheryl L Rifas-Shiman, Marie-France Hivert, Abby F Fleisch, Henning Tiemeier, and Emily Oken

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Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A population-based analysis., Wei Shen Tan, Quoc-Dien Trinh, Matthew H Hayn, Maya Marchese, Stuart R Lipsitz, Junaid Nabi, Kerry L Kilbridge, Justin A Vale, Bijan Khoubehi, Adam S Kibel, Maxine Sun, Steven L Chang, and Jesse D Sammon

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Frequent Versus Infrequent Bathing in Pediatric Atopic Dermatitis: A Randomized Clinical Trial., Ivan D Cardona, Erin E Kempe, Christine Lary, Julia H Ginder, and Neal Jain

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Heated Intraperitoneal Chemotherapy for Colorectal Carcinomatosis: Emerging Evidence., Rebecca A Snyder, Keith Fournier, Richard Royal, Alan P Venook, and George J Chang

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Implications of the Hemoglobin Glycation Index on the Diagnosis of Prediabetes and Diabetes., Daniel S Hsia, Neda Rasouli, Anastassios G Pittas, Christine W Lary, Anne Peters, Michael R Lewis, Sangeeta R Kashyap, Karen C Johnson, Erin S LeBlanc, Lawrence S Phillips, James M Hempe, Cyrus V Desouza, and D2d Research Group

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Integrating Interprofessional Case Scenarios, Allied Embedded Actors, and Teaching Into Formative Observed Structured Clinical Exams., Peggy R Cyr, Julie M Schirmer, Victoria Hayes, Corinn Martineau, and Meghan Keane

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Intubation of the COVID-19 Patient, Edmund Sears

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Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update., Dolores Shoback, Clifford J Rosen, Dennis M Black, Angela M Cheung, M Hassan Murad, and Richard Eastell

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Reproductive and developmental health effects of prenatal exposure to tetrachloroethylene-contaminated drinking water., Ann Aschengrau, Michael R Winter, Lisa G Gallagher, Veronica M Vieira, Lindsey J Butler, M Patricia Fabian, Jenny L Carwile, Amelia K Wesselink, Shruthi Mahalingaiah, Patricia A Janulewicz, Janice M Weinberg, Thomas F Webster, and David M Ozonoff

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The CD38 low natural killer cell line KHYG1 transiently expressing CD16 F158V in combination with daratumumab targets multiple myeloma cells with minimal effector NK cell fratricide, Subhashis Sarkar, Sachin K S Chauhan, John Daly, Alessandro Natoni, Heather Fairfield, Robert Henderson, Emma Nolan, Dawn Swan, Jinsong Hu, Michaela R Reagan, and Michael O'Dwyer

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The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients., Desmoid Tumor Working Group and Aaron Weiss

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Editorial: Identifying Individuals at Clinical High Risk of Psychosis in Different Cultures and Countries, TianHong Zhang, JiJun Wang, and Kristen A. Woodberry

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Differences in Pulmonary and Systemic Flow Measurements by Cardiac Magnetic Resonance vs Cardiac Catheterization and Relation to Collateral Flow in Single Ventricle Patients., Michael R Hart, Wendy Whiteside, Sunkyung Yu, Ray Lowery, Adam L Dorfman, Maryam Ghadimi Mahani, Prachi P Agarwal, and Jimmy C Lu

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#MeToo in EM: A Multicenter Survey of Academic Emergency Medicine Faculty on Their Experiences with Gender Discrimination and Sexual Harassment, Dave W. Lu, Michelle D. Lall, Jennifer Mitzman, Sheryl Heron, Ava Pierce, Nicholas D. Hartman, Danielle M. McCarthy, Joshua Jauregui, and Tania D. Strout

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Perivascular osteoprogenitors are associated with transcortical channels of long bones., Sierra H Root, Natalie K Y Wee, Sanja Novak, Clifford J Rosen, Roland Baron, Brya G Matthews, and Ivo Kalajzic

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Isolated Renal Artery Dissection: A Systematic Review of Case Reports., Anil Jha, Maxwell Afari, Ioannis Koulouridis, Tariq Bhat, and Lawrence Garcia

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Marrow Adipocytes: Origin, Structure, and Function., Francisco J A de Paula and Clifford J Rosen

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Efficacy and Safety of Carbon Dioxide Versus Air Insufflation for Colonoscopy in Deeply Sedated Pediatric Patients., Rajmohan Dharmaraj, Rachel Dunn, Julia Fritz, Mahua Dasgupta, Pippa Simpson, Jose Cabrera, Adrian Miranda, and Diana G Lerner

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The Parental Experience of Newborns With Neonatal Abstinence Syndrome Across Inpatient Care Settings: A Qualitative Study., Amy Buczkowski, Olivia Avidan, David Cox, and Alexa Craig

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Proper technical procedures improved outcomes in a retrospective analysis of EVAS FORWARD IDE trial 3-year results., Jeffrey P Carpenter, John S Lane, Jose Trani, Sajjad Hussain, Christopher Healey, Homayoun Hashemi, Robert Cuff, and Nellix Investigators

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The impact of age on in-hospital outcomes after transcarotid artery revascularization, transfemoral carotid artery stenting, and carotid endarterectomy., Hanaa Dakour-Aridi, Vikram S Kashyap, Grace J Wang, Jens Eldrup-Jorgensen, Marc L Schermerhorn, and Mahmoud B Malas

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Lipids in the Bone Marrow: An Evolving Perspective., Elizabeth Rendina-Ruedy and Clifford J Rosen

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Electrical cardioversion for atrial fibrillation in the emergency department: A large single-center experience., Andrew M Fried, Tania D Strout, and Andrew D Perron

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Clinical Performance Measures for Neurocritical Care: A Statement for Healthcare Professionals from the Neurocritical Care Society., Sarah Livesay, Herbert Fried, David Gagnon, Navaz Karanja, Abhijit Lele, Asma Moheet, Casey Olm-Shipman, Fabio Taccone, David Tirschwell, Wendy Wright, J Claude Hemphill Iii, and Neurocritical Care Society

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Commentary: Diffuse supravalvar aortic stenosis: Is the enemy of good always better?, Sunil P. Malhotra

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Dual Mobility for Monoblock Metal-on-Metal Revision-Is It Safe?, Nicholas D Colacchio, Clint J Wooten, John R Martin, John L Masonis, and Thomas K Fehring

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Endoscopic retrieval of magnetic foreign body ingestions with a nasal bridle: description of a novel technique (with video)., Duncan J Flynn, Douglas Howell, and Daniil Rolshud

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Endovascular Aneurysm Sealing is Associated with Higher Medium-Term Survival than Traditional EVAR., Thomas F X O'Donnell, Jeffrey P Carpenter, John S Lane, Jose Trani, Sajjad Hussain, Christopher Healey, Mahmoud B Malas, and Marc L Schermerhorn

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Exploring mechanisms of increased cardiovascular disease risk with antipsychotic medications: Risperidone alters the cardiac proteomic signature in mice., Megan Beauchemin, Ramaz Geguchadze, Anyonya R Guntur, Kathleen Nevola, Phuong T Le, Deborah Barlow, Megan Rue, Calvin P H Vary, Christine W Lary, Katherine J Motyl, and Karen L Houseknecht

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Greater Bone Marrow Adiposity Predicts Bone Loss in Older Women., Gina N Woods, Susan K Ewing, Sigurdur Sigurdsson, Deborah M Kado, Gudny Eiriksdottir, Vilmundur Gudnason, Trisha F Hue, Thomas F Lang, Eric Vittinghoff, Tamara B Harris, Clifford Rosen, Kaipin Xu, Xiaojuan Li, and Ann V Schwartz

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IGF-1 is associated with estimated bone strength in anorexia nervosa., P K Fazeli, A T Faje, E Meenaghan, S T Russell, M Resulaj, H Lee, C J Rosen, M L Bouxsein, and A Klibanski

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Mortality After Paclitaxel Coated Balloon Angioplasty and Stenting of Superficial Femoral and Popliteal Artery in the Vascular Quality Initiative., Daniel J Bertges, Art Sedrakyan, Tianyi Sun, Mohammad H Eslami, Marc Schermerhorn, Philip P Goodney, Adam W Beck, Jack L Cronenwett, and Jens Eldrup-Jorgensen

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Notch Dosage Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice, Christopher A. Blackwood, Alessandro Bailetti, Sayan Nandi, Thomas Gridley, and Jean M. Hébert

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Precision and Functional Genomics., Steve D M Brown and Joseph H Nadeau