Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2020

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COVID-19 and Disruptive Modifications to Cardiac Critical Care Delivery: JACC Review Topic of the Week., Jason N Katz, Shashank S Sinha, Carlos L Alviar, David M Dudzinski, Ann Gage, Samuel B Brusca, M Casey Flanagan, Timothy Welch, Bram J Geller, P Elliott Miller, Sergio Leonardi, Erin A Bohula, Susanna Price, Sunit-Preet Chaudhry, Thomas S Metkus, Connor G O'Brien, Alessandro Sionis, Christopher F Barnett, Jacob C Jentzer, Michael A Solomon, David A Morrow, and Sean van Diepen

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Pregnancy per- and polyfluoroalkyl substance concentrations and postpartum health in Project Viva, a prospective cohort., Susanna D Mitro, Sharon K Sagiv, Abby F Fleisch, Lindsay M Jaacks, Paige L Williams, Sheryl L Rifas-Shiman, Antonia M Calafat, Marie-France Hivert, Emily Oken, and Tamarra M James-Todd

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Are patients with rheumatologic diseases on chronic immunosuppressive therapy at lower risk of developing severe symptoms when infected with COVID-19?, Kiana Vakil-Gilani and Kenneth O'Rourke

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Management strategies for human babesiosis, Robert P. Smith, Klaus-Peter Hunfeld, and Peter J. Krause

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Man With Painful Erection., Christopher Allison, Christopher Hasslinger, and David Mackenzie

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New Graduate Orientation Evaluation: Are There Any Best Practices Out There?: A Scoping Review, Jennifer Laflamme and Kristiina Hyrkas

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Prolonged Cardiopulmonary Bypass is Associated With Endothelial Glycocalyx Degradation., Michael Robich, Sergey Ryzhov, Doreen Kacer, Monica Palmeri, Sarah M Peterson, Reed D Quinn, Damien Carter, Forest Sheppard, Timothy Hayes, Douglas B Sawyer, Joseph Rappold, Igor Prudovsky, and Robert S Kramer

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Repair of Spontaneous Left Atrial Dissection Resulting in Severe Paravalvular Native Mitral Valve Regurgitation, Tayler B. Eldridge, Jay N. Shah, Justin Poltak, James B. Powers, Reed D. Quinn, Marco N. Diaz, and Michael P. Robich

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Underrepresented Minorities in General Surgery Residency: Analysis of Interviewed Applicants, Residents, and Core Teaching Faculty, Benjamin T. Jarman, Andrew J. Borgert, Kara J. Kallies, Amit R. Joshi, Douglas S. Smink, George A. Sarosi, Lily Chang, John M. Green, Jacob A. Greenberg, Marc L. Melcher, Valentine Nfonsam, and James Whiting

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Early cerebral edema after cardiac arrest and its ramifications., Jonathan Rud, Teresa L May, Richard R Riker, and David B Seder

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COVID-19 and preeclampsia with severe features at 34-weeks gestation., John N Hansen, Jason Hine, and Tania D Strout

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Heparin-induced thrombocytopenia with thrombosis in COVID-19 adult respiratory distress syndrome, Richard R. Riker, Teresa L. May, Gilles L. Fraser, David J. Gagnon, Mahesh Bandara, Wesley R. Zemrak, and David B. Seder

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High ErbB3 activating activity in human blood is not due to circulating neuregulin-1 beta, Emmanuel Boateng, Joanne T. deKay, Sarah M. Peterson, Jacob Boles, Nathan Pinnette, Mary W. Sorcher, Michael P. Robich, Douglas B. Sawyer, and Sergey Ryzhov

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Improving HPV Vaccination Rates: A Stepped-Wedge Randomized Trial, Rebecca B. Perkins, Aaron Legler, Emily Jansen, Judith Bernstein, Natalie Pierre-Joseph, Terresa J. Eun, Dea L. Biancarelli, Thomas J. Schuch, Karin Leschly, Anny T. Fenton, William G. Adams, Jack A. Clark, Mari-Lynn Drainoni, and Amresh Hanchate

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Noninvasive Electrocardiography in the Perinatal Mouse., Lindsey A Fitzsimons, Victoria L Brewer, John Forrester, Adrian M Moran, and Kerry L Tucker

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Change in opioid policies in New England emergency departments, 2014 vs 2018., Maranatha M Teferi, Krislyn M Boggs, Janice A Espinola, Ramsey Herrington, Nathan W Mick, Maia S Rutman, Arjun K Venkatesh, Christopher P Zabbo, Kohei Hasegawa, Margaret E Samuels-Kalow, Scott G Weiner, and Carlos A Camargo

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BRAF-Mutated Erdheim-Chester Disease: Profound Response to Vemurafenib Visualized With Serial Multimodality Imaging., Javaughn Corey R Gray, Jongho Kim, Michael DiGianvittorio, Nancy K Feeley, Paul J Scheel, Stanley S Siegelman, Elliot K Fishman, and Steven P Rowe

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Development of the Adult ECMO Specialist Certification Examination., Jeffrey B Riley, Mark T Lucas, Keith A Samolyk, James A Reagor, Subject Matter Expert Working Group, Joseph G Timpa, Christopher N Pierce, Thomas J Preston, Edward M Darling, Bruce E Searles, Robert D Longenecker, Ashley B Hodge, Kevin A Charette, Robert C Groom, David C Fitzgerald, Justin R Sleasman, Cory M Alwardt, Desiree K Bonadonna, Mark P Shepard, and William E Harris

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Evaluation of factors influencing surgical treatment costs for distal biceps rupture., Ross Feller, Damian Illing, Chelsea Allen, Angela Presson, Andrew Tyser, and Nikolas Kazmers

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Medical genetics education in the midst of the COVID-19 pandemic: Shared resources, Debra S. Regier, Wendy E. Smith, and Heather M. Byers

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Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach, Emma V. Preston, Thomas F. Webster, Birgit Claus Henn, Michael D. McClean, Chris Gennings, Emily Oken, Sheryl L. Rifas-Shiman, Elizabeth N. Pearce, Antonia M. Calafat, Abby F. Fleisch, and Sharon K. Sagiv

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Reproducibility of a prediabetes classification in a contemporary population., Chhavi Chadha, Anastassios G Pittas, Christine W Lary, William C Knowler, Ranee Chatterjee, Lawrence S Phillips, Vanita R Aroda, Michael R Lewis, Richard Pratley, Myrlene A Staten, Jason Nelson, Neda Rasouli, Irwin Brodsky, and D2d Research Group

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Weight Loss and Concomitant Adipose Autophagy in Methionine-Restricted Obese Mice is Not Dependent on Adiponectin or FGF21., Diana Cooke, Dwight Mattocks, Sailendra N Nichenametla, Rea P Anunciado-Koza, Robert A Koza, and Gene P Ables

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Comparison of intraoperative tranexamic acid and epsilon-aminocaproic acid in cardiopulmonary bypass patients, Mark Broadwin, Patrick E. Grant, Michael P. Robich, Monica L. Palmeri, Frances L. Lucas, Joseph Rappold, and Robert S. Kramer

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Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids, Ashwani Kumar Gupta, Prasenjit Sarkar, Jason A. Wertheim, Xinchao Pan, Thomas J. Carroll, and Leif Oxburgh

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Unprocessed Red Meat and Processed Meat Consumption., Daniel A Meyer

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Unprocessed Red Meat and Processed Meat Consumption., Daniel A Meyer

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A Collaborative Learning Assessment of Developmental Care Practices for Infants in the Cardiac Intensive Care Unit., Thomas Miller, Amy J Lisanti, Madolin K Witte, Justin J Elhoff, William T Mahle, Karen C Uzark, Nneka Alexander, and Samantha C Butler

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ACR Appropriateness Criteria® Placenta Accreta Spectrum Disorder., Expert Panel on Women’s Imaging, Liina Poder, Stefanie Weinstein, Katherine E Maturen, Vickie A Feldstein, David C Mackenzie, Edward R Oliver, Thomas D Shipp, Loretta M Strachowski, Betsy L Sussman, Eileen Y Wang, Therese M Weber, Bradford P Whitcomb, and Phyllis Glanc

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Assessment of Maternal Glycemia and Newborn Size Among Pregnant Women Who Use Wood Stoves in Northern New England., Abby F Fleisch, Shravanthi M Seshasayee, Eric Garshick, Jonathan W Chipman, Petros Koutrakis, Emily R Baker, and Margaret R Karagas

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Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice, Yong-Ri Jin, Xiang Hua Han, Katsuhiko Nishimori, Dan Ben-Avraham, Youn Jeong Oh, Jae-Won Shim, and Jeong Kyo Yoon

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Clinical impact of sex on carotid revascularization., Kirsten D Dansey, Alexander B Pothof, Sara L Zettervall, Nicholas J Swerdlow, Patric Liang, Joseph R Schneider, Brian W Nolan, and Marc L Schermerhorn

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Differences in Naloxone Prescribing by Patient Age, Ethnicity, and Clinic Location Among Patients at High-Risk of Opioid Overdose., David Kispert, Jenny L Carwile, Kristen B Silvia, Elizabeth B Eisenhardt, and Kinna Thakarar

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Impact of Cardiac Implantable Electronic Device Infection: A Clinical and Economic Analysis of the WRAP-IT Trial., Bruce L Wilkoff, Giuseppe Boriani, Suneet Mittal, Jeanne E Poole, Charles Kennergren, G Ralph Corey, John C Love, Ralph Augostini, Svein Faerestrand, Sherman S Wiggins, Jeff S Healey, Reece Holbrook, Jeffrey D Lande, Daniel R Lexcen, Sarah Willey, and Khaldoun G Tarakji

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Involvement of early embryonic miR-409-3p in the establishment of anxiety levels in female mice, David A. Dickson, Patrizia Stohn, Lorena Saavedra Rodriguez, Arturo Hernandez, Anne Harrington, Lucy Liaw, and Larry A. Feig

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Lung Cancer Screening Guidelines Implementation in Primary Care: A Call to Action, Chyke A. Doubeni, John M. Wilkinson, Neil Korsen, and David E. Midthun

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Observed emotional reactivity in response to frustration tasks in psychiatrically hospitalized youth with autism spectrum disorder, Jessie B. Northrup, Matthew Goodwin, Joshua Montrenes, Jessica Vezzoli, Josh Golt, Christine B. Peura, Matthew Siegel, and Carla Mazefsky

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Parkinson's disease and osteoporosis: basic and clinical implications, Carolina A. Figueroa and Clifford J. Rosen

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Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling., Matthew A Held, Emily Greenfest-Allen, Su Su, Christian J Stoeckert, Matthew P Stokes, and Don M Wojchowski

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The many variants of psoriasis., Karl T Clebak, Leesha Helm, Matthew F Helm, and Elizabeth V Seiverling

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The voice of the radiologist: Enabling patients to speak directly to radiologists., Nathan M Cross, Joseph Wildenberg, Geraldine Liao, Sean Novak, Thomas Bevilacqua, James Chen, Evan Siegelman, and Tessa S Cook

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Yes, it is the time, Jens Eldrup-Jorgensen and Fred Weaver

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A Clinical Toolkit Improves MMP Internal Medicine Provider Comfort and Perceived Skill with Assessment of Adult ADHD, C Jason Mallo and Sara J. Powers

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A novel, multimodal, interprofessional program to improve communication skills in the CICU, Rebecca Hutchinson, Liz Scharnetzki, Sanjeev Francis, Isabella Stumpf, Charles Adler, Jesse Woodlock, and Katrina Monahan

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Anti-adipogenicand cytoprotectiveeffects of CTHRC1 and its potential role in the regulation of aging, Igor Prudovsky, Matthew Siviski, Doreen Kacer, Yongri Jin, Victoria DeMambro, Patrizio Stohn, Kathleen Pyburn, Rachel Berkovitch, Alaa Makki, and Volkhard Lindner

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Association of Affect Dynamics and Psychotic Symptoms in Clinical High Risk and Early Course Psychosis, K A. Woodberry, W Cook, K Elacqua, K A. Johnson, K Powers, M Graham, A Cloutier, T Twhigg, D Robbins, and R Mesholam-Gately

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Beyond the brain: ?-Synuclein and its implications in bone and fat metabolism, C A. Figueroa, P Bajgain, and C J. Rosen

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Chemokine dynamics and the inflammatory response after cardiac injury, Joanne Taylor deKay, David B. Seder, Michael P. Robich, Douglas B. Sawyer, Teresa May, John Dziodzio, Ivette F. Emery, F.L. Lee Lucas, Angela Leclerc, Barbara McCrum, Christine Lord, Ashley Eldridge, Fumito Ichinose, Richard Riker, and Sergey V. Ryzhov

COVID-19 Research Response, Ivette Emery, Paul K. Han, Lee Lucas, Scot Remick, Volkhard Lindner, Sergey Ryzhov, and Cal Vary

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Current practice of trauma informed care in pregnancy among obstetric providers, Morgan R. Abbey and Rebecca Hunt

Description MMC Institute for Teaching Excellence (MITE), Clinical Teaching Certificate: the Development of an Innovative Asynchronous Faculty Development Primer, Isaac Stickney and Sue Rose

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DGAT Activity is Dispensable for Myeloma Cell Proliferation, C S. Murphy, H Campbell, V DeMambro, M Farrell, S Costas, C Vary, and M R. Reagan

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Documentation of Obesity on the Problem List and Referral Rates Among Obese Children and Adults, Heidi Walls, Christina Holt, Amy Haskins, and William Dexter

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Does your patient know if they have prediabetes?, Sophia Adams, Christina Holt, and Amy Haskins

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Don’t Shoot the Messenger: Surgical Programs Can Do More To Keep Applicants Informed, Alison N. Pletch, Frederica Jackson, Danielle Shaw, Christopher Whiting, and James F. Whiting

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Effect of 3D Lung Nodule Educational Tool on Patient Distress Following LDCT Incidental Finding of Lung Nodule, Theresa Roelke and Ivette Emery

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Empathy in Individuals Who Experience Psychosis: An Empathetic Perspective, Kristen Woodberry and Katherine Elacqua

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Evaluating Efficacy of a Recently Implemented Malnutrition Screening Tool, Rebecca Edwards and Paul Blakeslee

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Evaluation of a Resident-Driven Trauma-Sensitive Yoga Program for Female Immigrant Primary Care Patients, Katherine Rizzolo, Maha Jaber, Jessica Schaumburg, Kiana Vakil-Gilani, and Nicole Rebusi

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Evidence based estimation of energy and protein needs in adults with major burn injuries, Ashley Lazarz and Samantha Buttarazzi Waller

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Exploring Patient Activation in the Emergency Department at Maine Medical Center, Rushi Shaw, Samir Haydar, Tania Strout, and Karla Hyde

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Factors correlating with interprofessional engagement in debriefing following pediatric simulation-based team training., Richard Byrnes, Zachary Priest, Christine Schreiber, Justin Michaud, Tracie Barbour, Michael Ferguson, Micheline Chipman, Wendy Craig, and Leah Mallory

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Hospital birth volume impacts resuscitation and outcomes of infants after therapeutic hypothermia, Prathusha Yerramilli, Channing Pooley, Nabeel Hashmi, Jay Kerecman, Misty Melendi, and Alexa Craig

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Impact of Sleep on Mood & Psychotic Symptoms in Early & Emerging Psychosis, K Penner Coxon, K A. Johnson, K Powers, K Elacqua, W L. Cook, R I. Mesholam-Gately, and K A. Woodberry

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Implementation of CRISPR/Cas editing analysis tool ICE to detect multiple edited alleles in mice, Larisa Ryzhova, Anne Harrington, Samantha White, and Lucy Liaw

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Improving vitamin D management in an adult cystic fibrosis program., Stefanie DiLoretor, Alicia Murry, Tegan Smith, and Lauren Tate

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Innovations at MaineHealth-Introduction, Susan Ahern

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Insulin-like Growth Factor Binding Protein 2 May Promote Bone Loss After Vertical Sleeve Gastrectomy: A Pilot Study and Preliminary Data, A N. Pletch, B Harris, P T. Le, and Clifford Rosen

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Investigating the Effect that Inhibiting Fatty Acid Binding Proteins 4 or 5 Have on Myeloma Cell Proliferation, Anastasia D’Amico, Mariah Farrell, and Michaela Reagan

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Irisin Stimulates Osteoclast Differentiation and Function, Eben Estell, Phuong Le, Yosta Vegting, Hyeonwoo Kim, Roland Baron, Bruce Spiegelman, and Clifford Rosen

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Lean Phenotype Induced by Methionine Restriction in Mice is Associated with Proteomic Changes in Perivascular Adipose Tissue, Bethany H. Fortier, Calvin PH Vary, Robert A. Koza, Gene P. Ables, and Lucy Liaw

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Loss of vitamin A stores impairs cardiac workload and function under stress conditions, Amanda J. Favreau‐Lessard, MaryAnn Asson‐Batres, Douglas B. Sawyer, and Ilka Pinz

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MaineHealth Innovation COVID-19 Successes, Susan Ahern

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MMC Biobank: A resource for translational research., Anne C. Breggia, Sue LaPierre, Christopher Keister, Hanna Renedo, Dawn Charnetzky, Hannah Brown, Howard Feller, Susan Nester, Robert Christman, Michael Jones, Tony Sellner, Liz Hamir, Lindsay Cote, and Heidi Ingersoll

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Notch signaling regulates perivascular adipose tissue (PVAT) function during diet-induced obesity, Chenhao Yang, Joshua M. Boucher, Larisa M. Ryzhova, and Lucy Liaw

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Opening Remarks - Costas T. Lambrew Research Retreat 2020, Douglas Sawyer

Patients’ expectations of the benefits of large-panel genomic tumor testing, Eric Anderson, John DiPalazzo, and Paul Han

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Pharmacogenetic and MicroRNA Effects of Beta Blocker Association with Increased Bone Mineral Density in Humans, Kathleen T. Nevola, Douglas P. Kiel, Andrew R. Zullo, Ines Foessl, Barbara Obermayer-Pietsch, Katherine Motyl, and Christine W. Lary

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Population and hospitalization characteristics of patients served by the Preble Street Learning Collaborative (PSLC) who leave the hospital with self-directed discharge, Hannah Martin, Emily Zarookia, Adam Normandin, Kathleen Fairfield, Wendy Craig, and Debra Rothenberg

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Predicting Polymicrobial Stone in Patients Undergoing PCNL, William Daly, Erin Santos, Christopher Stockdale, and Johann Ingimarsson

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Primary cilia-mediated ventricular maturation in congenital heart disease: A role for ErbB signaling?, Lindsey A. Fitzsimmons, Sergey Ryzhov, and Kerry L. Tucker

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Prrx1-CreAlplfl/flmice, a model for further investigations into the pathophysiological changes in Hypophosphatemia, Victoria DeMambro, Jennifer Daruszka, Daniel Brooks, Mary Bouxsein, and Cliff Rosen

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Reliability and Criterion Validity of Ultrasonic Measurements of the Supraspinatus and Infraspinatus Cross-Sectional Area, Dirk Kokmeyer, Lori-Thein Brody, Shane Koppenhaver, and Charles Thigpen

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Role of Zfp467in Mediating the Anti-Adipogenic and Pro-Osteogenic Effects of PTH: An In-VitroAnalysis, H Liu, I Leon Calle, P T. Le, R Baron, and C J. Rosen

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Rural harm reduction access and regional trends., Kinna Thakarar

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Sclerostin antibody normalizes decreased trabecular bone and increased bone marrow adipose tissue caused by whole-body irradiation in mice, Samantha Costa, Heather Fairfield, Mariah Farrell, Connor Murphy, Ashley Soucy, Gill Holdsworth, and Michaela R. Reagan

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Stigmatizing Attitudes Towards People who Smoke: A Survey of Primary Care Physicians, Liz Scharnetzki, Leo B. Waterston, Susan E. Leeds, Jamie L. Studts, Neil Korsen, and Paul K J Han

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Study Strategies for General Surgery Residents Preparing for the ABSITE: What to Keep, Discard, and Adopt, A Pletch, Wendy Craig, J Rappold, J Whitting, and C Turner

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Targeting bone marrow adipose tissue and the FABP family increases efficacy of dexamethasone in MM, Mariah Farrell, Heather Fairfield, Carolyne Falank, Samantha Costa, Anastasia D’Amico, Dominic Bowers, and Michaela R. Reagan

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Testosterone (T) and estradiol (E2) therapy alone can suppress gonadal function in transgender patients., India I. Pappas, Wendy Craig, Lindsey V. Spratt, and Daniel I. Spratt

The clinical significance of molecular subtyping in glioblastoma, Wendy Craig, Rebecca Bystrom, Jens Rueter, and Christine Lu-Emerson

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The dynamics of human bone marrow adipose tissue in response to feeding and fasting, Gisela Pachón-­Peña, Pouneh K. Fazeli, Miriam A. Bredella, Elizabeth K. O’Donell, Anne Klibanski, and Clifford J. Rosen

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The Impact of an InterprofessionalEducation Curriculum on Medical, Pharmacy and Social Work Students’ Interdisciplinary Perceptions and Teamwork, Victoria Hayes, Corinn Martineau, Julie Schirmer, and Peggy Cyr

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The myokine irisin stimulates osteoclast differentiation and function, Eben G. Estell, P T. Le, Y Vegting, H Kim, R Baron, B Speigelman, and C J. Rosen

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The Role of Smooth Muscle Cell Notch2 in Atherosclerotic Plaque Burden and Composition, Jess Davis-Knowlton, Jackie Turner, Anne Harrington, and Lucy Liaw

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Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression, Virginia Lee

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Dysphagia After Cardiopulmonary Resuscitation: A Case of Aspirated Dentures., Elizabeth J Hamilton, Casey MacVane, and Tania D Strout

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The Effect of Prognostic Communication on Patient Outcomes in Palliative Cancer Care: a Systematic Review, Naomi C. van der Velden, Maartje C. Meijers, Paul K. J. Han, Hanneke W. van Laarhoven, Ellen M. Smets, and Inge Henselmans

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Tuberculosis and foreign-born populations in the United States: A mixed methods pilot study of media reporting and political identification, Angel N. Desai, Shravanthi M. Seshasayee, Maimuna S. Majumder, Britta Lassmann, Lawrence C. Madoff, Emily L. Cohn, and John S. Brownstein

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Coronary Artery Disease Assessed by Computed Tomography-Based Leaman Score in Patients With Low-Risk Transcatheter Aortic Valve Implantation., Yuichi Ozaki, Hector M Garcia-Garcia, Toby Rogers, Rebecca Torguson, Paige E Craig, Alexandre Hideo-Kajita, Paul Gordon, Afshin Ehsan, Puja Parikh, Thomas Bilfinger, David Butzel, Scott Buchanan, Robert Levitt, Chiwon Hahn, Maurice Buchbinder, Nicholas Hanna, Robert Garrett, Sean R Wilson, John A Goncalves, Syed Ali, Federico M Asch, Gaby Weissman, Christian Shults, Itsik Ben-Dor, Lowell F Satler, and Ron Waksman