Incorporated in 1868, MMC is the state’s largest medical center, licensed for 700 beds and employing more than 9,600 people. Maine Medical Center’s unique role as both a community hospital and a referral center requires an unparalleled depth and breadth of services, including the state’s only allopathic medical school program, through a partnership with Tufts University School of Medicine, and a world-class biomedical research center, the MaineHealth Institute for Research.

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Submissions from 2019

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Vertical transmission rates of Borrelia miyamotoi in Ixodes scapularis collected from white-tailed deer., Seungeun Han, Charles Lubelczyk, Graham J Hickling, Alexia A Belperron, Linda K Bockenstedt, and Jean I Tsao

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Intestinal clock system regulates skeletal homeostasis., Masanobu Kawai, Saori Kinoshita, Miwa Yamazaki, Keiko Yamamoto, Clifford J Rosen, Shigeki Shimba, Keiichi Ozono, and Toshimi Michigami

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Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells., S Spencer Scott, Xuehui Yang, Michael Robich, Lucy Liaw, and Joshua M Boucher

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Abdominal Pain After a Football Game., Heidi M Goddard, Casey Z MacVane, and Tania D Strout

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Achievement of Guideline-Recommended Weight Loss Among Patients With Ischemic Stroke and Obesity., Jennifer L Dearborn, Catherine M Viscoli, Lawrence H Young, Mark J Gorman, Karen L Furie, and Walter N Kernan

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A randomized phase II study of cabozantinib versus weekly paclitaxel in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study., Ursula A Matulonis, Michael W Sill, Vicky Makker, David G Mutch, Jay W Carlson, Christopher J Darus, Robert S Mannel, David P Bender, Erin K Crane, and Carol Aghajanian

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Assessing feasibility of resources at health facilities in Uganda to diagnose pregnancy and neonatal outcomes., James H Stark, Eve Wool, Lena Tran, Elizabeth Robinson, Meaghan Chemelski, Daniel Weibel, Wan-Ting Huang, Sonali Kochhar, Janet R Hardy, Steven Bailey, Edward Galiwango, and Dan Kajungu

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A systematic review of micronutrient deficiencies in pediatric inflammatory bowel disease., Julia Fritz, Cassandra Walia, Abdul Elkadri, Rebecca Pipkorn, Rachel K. Dunn, Rita Sieracki, Praveen S. Goday, and Jose Mariano Cabrera

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Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling., Jessica Davis-Knowlton, Jacqueline E Turner, Anna Turner, Sydney Damian-Loring, Nicholas Hagler, Terry Henderson, Ivette F Emery, Kyle Bond, Christine W Duarte, Calvin P H Vary, Jens Eldrup-Jorgensen, and Lucy Liaw

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Do we need continuous electroencephalography after cardiac arrest?, Teresa May, Richard R. Riker, and David Seder

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Inpatient Psychiatric Treatment of Serious Behavioral Problems in Children with Autism Spectrum Disorder (ASD): Specialized Versus General Inpatient Units., Briana J. Taylor, Kevin B. Sanders, Marie Kyle, Kahsi A. Pedersen, Jeremy Veenstra-Vanderweele, and Matthew Siegel

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Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells., Berna Uygur, Evgenia Leikina, Kamran Melikov, Rafael Villasmil, Santosh K Verma, Calvin P H Vary, and Leonid V Chernomordik

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Multiple Myeloma and Fatty Acid Metabolism., Majdi Masarwi, Abigail DeSchiffart, Justin Ham, and Michaela R Reagan

Point-of-Care versus Central Laboratory Glucose Testing in Postoperative Cardiac Surgery Patients., Robert S. Kramer, Monica Palmeri, Michael Robich, Frances L. Lucas, Robert Groom, Timothy Hayes, Marie Janoushek, Joseph F. Rappold, William L. Swartz, and Reed Quinn

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Prognostic value of a modified surprise question designed for use in the emergency department setting., Samir A Haydar, Tania D Strout, Alicia G Bond, and Paul Kj Han

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Why Residents Quit: National Rates of and Reasons for Attrition Among Emergency Medicine Physicians in Training., Dave W. Lu, Nicholas D. Hartman, Jeffrey Druck, Jennifer Mitzman, and Tania D. Strout

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An Analysis of Psychoactive Medications Initiated in the ICU but Continued Beyond Discharge: A Pilot Study of Stewardship., Nicole Lynn Kovacic, David J Gagnon, Richard R Riker, Sijin Wen, and Gilles L Fraser

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Cholecystectomy reduced major complications vs catheter drainage in high-risk patients with acute cholecystitis., Joseph F. Rappold

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Aligning Strategic Interests in an Academic Medical Center: A Framework for Evaluating GME Expansion Requests, Kalli Varaklis, Mark G. Parker, Jordan S. Peck, and Robert G. Bing-You

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A simple matrix to predict treatment success and long-term survival among patients undergoing pancreatectomy., Timothy L Fitzgerald, Lucas Hunter, Catalina Mosquera, Charulata Jindal, Tithi Biswas, Emmanuel Zervos, and Jimmy T Efird

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Clinical Disorders of the Kidney., James C Chan

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Educating Caregivers To Provide Safe Care., Marjorie S. Wiggins, Peter Bates, and James Benneyan

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Empyema commission of 1918-Impact on acute care surgery 100 years later., Jamie Tung, Damien Carter, and Joseph Rappold

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Evaluation and Management of Neck and Back Pain., John W Martel and Samuel B Potter

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Impact of Contralateral Symmetry Procedures on Long-Term Patient-Reported Outcomes following Unilateral Prosthetic Breast Reconstruction., Shantanu N Razdan, Hina Panchal, Claudia R Albornoz, Andrea L Pusic, Colleen C McCarthy, Peter G Cordeiro, Joseph J Disa, Babak J Mehrara, and Evan Matros

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Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations., Peter C Frommelt, Chenwei Hu, Felicia Trachtenberg, Jeanne Marie Baffa, Richard J Boruta, Shahryar Chowdhury, James F Cnota, Andreea Dragulescu, Jami C Levine, Jimmy Lu, Laura Mercer-Rosa, Thomas Miller, Amee Shah, Timothy C Slesnick, Gary Stapleton, Jessica Stelter, Pierre Wong, and Jane W Newburger

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Intensity of Glycemic Control Affects Long-Term Survival After Coronary Artery Bypass Graft Surgery., Michael P Robich, Alexander Iribarne, Bruce J Leavitt, David J Malenka, Reed D Quinn, Elaine M Olmstead, Cathy S Ross, Douglas B Sawyer, John D Klemperer, Robert A Clough, Robert S Kramer, Yvon R Baribeau, Gerald L Sardella, Anthony W DiScipio, and Northern New England Cardiovascular Disease Study Group

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Introduction to the supplement on cellular therapies in trauma and critical care medicine., Shibani Pati, Martin Schreiber, and Joseph Rappold

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Low-dose compared to manufacturer-recommended dose four-factor prothrombin complex concentrate for acute warfarin reversal., Wesley Zemrak, Francis Manuel, Kathryn E Smith, Stephen Rolfe, Timothy Hayes, Robert L Trowbridge, Brian Carlone, and David Seder

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Low-Dose Prothrombin Complex Concentrate in Patients with Left Ventricular Assist Devices., Caitlin S Brown, Wesley R Zemrak, Kaitlin J Dyer, and Stephen Rolfe

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Palliative Care Clinician Overestimation of Survival in Advanced Cancer: Disparities and Association With End-of-Life Care., Robert Gramling, Elizabeth Gajary-Coots, Jenica Cimino, Kevin Fiscella, Ronald Epstein, Susan Ladwig, Wendy Anderson, Stewart C Alexander, Paul K Han, David Gramling, and Sally A Norton

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Patients with end-stage renal disease have poor outcomes after endovascular abdominal aortic aneurysm repair., Sevan Komshian, Alik Farber, Virendra I Patel, Philip P Goodney, Marc L Schermerhorn, Elizabeth A Blazick, Douglas W Jones, Denis Rybin, Gheorghe Doros, and Jeffrey J Siracuse

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Posttransplant Malignancy., Ana P Rossi and Christina L Klein

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Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton., David E Maridas, Elizabeth Rendina-Ruedy, Ron C Helderman, Victoria E DeMambro, Daniel Brooks, Anyonya R Guntur, Beate Lanske, Mary L Bouxsein, and Clifford J. Rosen

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Providing mental health care in teh context of online mental health notes: advice from patients and mental health clinicians., Maura Pisciotta, Lauren Denneson, Holly B. Williams, Susan Woods, Anais Tuepker, and Steven K. Dobscha

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Recovery of Kidney Dysfunction After Transcatheter Aortic Valve Implantation (from the Northern New England Cardiovascular Disease Study Group)., Amir Azarbal, David J Malenka, Yi-Ling Huang, Cathy S Ross, Richard J Solomon, James T DeVries, James M Flynn, David Butzel, Matthew McKay, and Harold L Dauerman

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Sedative and Analgesic Drug Sequestration After a Single Bolus Injection in an Ex Vivo Extracorporeal Membrane Oxygenation Infant Circuit., Viviane G Nasr, Jonathan Meserve, Luis M Pereira, David Faraoni, Steve Brediger, Susan Goobie, Ravi Thiagarajan, and James A DiNardo

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Symptomatic Adjacent Level Disease Requiring Surgery: Analysis of 10-Year Results From a Prospective, Randomized, Clinical Trial Comparing Cervical Disc Arthroplasty to Anterior Cervical Fusion., George M Ghobrial, William F Lavelle, Jeffrey E Florman, K Daniel Riew, and Allan D Levi

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Why the disconnect? Problems with a clamp style catheter connector., Ryan Mountjoy, Craig Curry, Olga Diomede, and Paula McKinley

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Wilderness Neurology., Sarah M Schlein, Paul G Marcolini, and Evie G Marcolini

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Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients., Mohammad Saiful Islam, Noriyuki Namba, Yasuhisa Ohata, Makoto Fujiwara, Chiho Nakano, Shinji Takeyari, Kei Miyata, Yukako Nakano, Kenichi Yamamoto, Hirofumi Nakayama, Taichi Kitaoka, Takuo Kubota, and Keiichi Ozono

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Correction: Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1, Subhasis Das, Rakesh Sathish Nair, Rajakishore Mishra, Gautam Sondarva, Navin Viswakarma, Hazem Abdelkarim, Vadim Gaponenko, Pradeep Sathyanarayana, Basabi Rana, and Ajay Rana

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Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics., Tithi Biswas, Charulata Jindal, Timothy L Fitzgerald, and Jimmy T Efird

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VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease., John F Keaney and Clifford J Rosen

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A Public Health Perspective on Screening for Psychosis Within General Practice Clinics., Leda Kennedy, Kelsey A Johnson, Joyce Cheng, and Kristen A Woodberry

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Association of hypokalemia with an increased risk for medically treated arrhythmias., Colin T Phillips, Junmei Wang, Leo Anthony Celi, Zhengbo Zhang, and Mengling Feng

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Bone Marrow Adiposity- Special Edition., Beata Lecka-Czernik and Clifford J Rosen

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Commentary: 2018 Stroke Guidelines., Andrew D. Perron and John H. Burton

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Development of a 3D bone marrow adipose tissue model., Heather Fairfield, Carolyne Falank, Mariah Farrell, Calvin Vary, Joshua M Boucher, Heather Driscoll, Lucy Liaw, Clifford J Rosen, and Michaela R Reagan

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Disability-Adjusted Life-Years Due to Stroke in Kenya., Lydia Kaduka, Erastus Muniu, Jane Mbui, Chrispine Oduor Owuor, Robai Gakunga, Judith Kwasa, Sylvanus Wabwire, Nathan Okerosi, Anne Korir, and Scot C Remick

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Dyspnea: diagnosis of hyperthyroidism by cardiac catheterization., Jay Shah, Louis Coyle, Joel Wirth, and Thomas Ryan

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Educational preferences among residents in the ICU, Jason Block and Patricia Lerwick

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Effective Advocacy for Patients and Communities., Cynthia Haq, Melissa Stiles, Debra Rothenberg, and Heather Lukolyo

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Evaluation of portable colposcopy and human papillomavirus testing for screening of cervical cancer in rural China, Haley Newman, Jilin Hu, Xiao Li, Jing He, Leslie Bradford MD, Songmei Shan, Xiaomei Wu, Bin Zhu, Wenyang Yang, Bingqin Fu, Baosheng Zhu, and Guangping Gao

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Evaluations of serum potassium during pentobarbital administration in critically ill patients., Kathryn Smith, William Crall, David Gagnon, Elizabeth Glisic, David Seder, and Richard Riker

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Evaluation the transition from dexmedetomidine to enteral clonidine in adult ICU patients., Nicholas Pozzessere, Richard Riker, Gilles Fraser, David Gagnon, Jonathan Rud, Allison Fluke, and Elizabeth Glisic

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Fibrinolysis shutdown in trauma: historical review and clinical implications., Hunter B Moore, Ernest E Moore, Matthew D Neal, Forest R Sheppard, Lucy Z Kornblith, Dominik F Draxler, Mark Walsh, Robert L Medcalf, Mitch J Cohen, Bryan A Cotton, Scott G Thomas, Christine M Leeper, Barbara A Gaines, and Angela Sauaia

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Findings of a Statewide Environmental Lead Inspection Program Targeting Homes of Children With Blood Lead Levels as Low as 5 µg/dL., Rachel Cluett, Abby Fleisch, Kathy Decker, Eric Frohmberg, and Andrew E. Smith

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Increasing medical student interest in nephrology., Stephen M Sozio, Kurtis A Pivert, Hitesh H Shah, Harini A Chakkera, Abdo R Asmar, Manu R Varma, Benjamin D Morrow, Ankit B Patel, Katlyn Leight, and Mark G Parker

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Increasing Referrals to a Community Paramedicine Fall Prevention Program Through Implementation of a Daily Management System., Julianne B. Ontengco

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Increasing stone complexity does not affect fluoroscopy time in percutaneous nephrolithotomy., Annah Vollstedt, Johann Ingimarsson, Lawrence Dagrosa, and Vernon Pais

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In Reply: Symptomatic Adjacent Level Disease Requiring Surgery: Analysis of 10-Year Results From a Prospective, Randomized, Clinical Trial Comparing Cervical Disc Arthroplasty to Anterior Cervical Fusion., George M Ghobrial, William F Lavelle, Jeffrey E Florman, K Daniel Riew, and Allan D Levi

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In vitro tissue-engineerd adipose constructs for modeling disease., Connor S Murphy, Lucy Liaw, and Michaela R Reagan

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Isolation and identification of endogenous RFamide-related peptides 1 and 3 in the mouse hypothalamus., Emilia Gospodarska, Leslie P Kozak, and Julia Jaroslawska

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Long-Term Culture of Nephron Progenitor Cells Ex Vivo., Aaron C Brown, Ashwani K Gupta, and Leif Oxburgh

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Long-term impact of the Vascular Study Group of New England carotid patch quality initiative., Leia Edenfield, Elizabeth Blazick, Christopher Healey, Robert Hawkins, Paul Bloch, Jens Eldrup-Jorgensen, and Brian Nolan

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Loperamide cardiotoxicity: a byproduct of the opioid epidemic., Sebastian Jablonski, Joshua Cowgill, and James Powers

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Maine Medical Center Research Institute: 2019 Year in Review, Maine Medical Center Research Institute

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Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells., Michaela Tencerova, Elizabeth Rendina-Ruedy, Ditte Neess, Nils Færgeman, Florence Figeac, Dalia Ali, Morten Danielsen, Anders Haakonsson, Clifford J Rosen, and Moustapha Kassem

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Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice., Zhongbo Liu, Maria E Solesio, Mitchell B Schaffler, Dorra Frikha-Benayed, Clifford J Rosen, Haim Werner, John J Kopchick, Evgeny V Pavlov, Andrey Y Abramov, and Shoshana Yakar

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Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services., Kinna Thakarar, Kristina E Rokas, F L Lucas, Spencer Powers, Elizabeth Andrews, Christina DeMatteo, Deirdre Mooney, Marcella H Sorg, August Valenti, and Mylan Cohen

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National trends in contralateral prophylactic mastectomy in women with locally advanced breast cancer., Hinaben Panchal, Melissa L Pilewskie, Clifford C Sheckter, Claudia R Albornoz, Shantanu N Razdan, Joseph J Disa, Peter G Cordeiro, Babak J Mehrara, and Evan Matros

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Neuropathy and neural plasticity in the subcutaneous white adipose depot., Magdalena Blaszkiewicz, Jake W Willows, Amanda L Dubois, Stephen Waible, Kristen DiBello, Lila L Lyons, Cory P Johnson, Emma Paradie, Nicholas Banks, Katherine Motyl, Merilla Michael, Benjamin Harrison, and Kristy L Townsend

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Omental Infarction with Acute Appendicitis in an Overweight Young Female: A Rare Presentation., Vishnu R Mani, Shantanu Razdan, Tonny Orach, Aleksandr Kalabin, Rinil Patel, Ali Elsaadi, Kiyoe Sullivan, and Federico Gattorno

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Platypnea-orthodeoxia: a curable cause of recalcitrant hypoxia., Joshua Cowgill, David Lapham, Sebastian Jablonski, and Joseph Wight

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Prospective assessment of sedation scales and wakefulness in medical and neurological ICU patients., Pasquale Marotte, Caitlin Brown, Teresa May, Richard Riker, and Gilles Fraser

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Pupillometry data 6 hours after ROSC predicts poor outocome after cardiac arrest., Richard Riker, Tyler Nussinow, Mary Sawyer, Bailey West, Philip Stone, Ashley Eldridge, Teresa May, and David Seder

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Quantitative Analysis of Surgical Residency Reform: Using Case-Logs to Evaluate Resident Experience., Sarah B Cairo, Wendy Craig, Caitlin Gutheil, Paul K J Han, Kristiina Hyrkas, Lynda Macken, and James F Whiting

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Reinitiation of Electroconvulsive Therapy 4 Weeks After the Diagnosis of ECT-Induced Takotsubo Cardiomyopathy., Kaitlin Clifford, Waseem Chaudhry, Sarah Muscat, Christopher Connors, and Dena Whitesell

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Relative contributions of parental intention and provider recommendation style to HPV and meningococcal vaccine receipt., Terresa J Eun, Amresh Hanchate, Anny T Fenton, Jack A Clark, Marisa N Aurora, Mari-Lynn Drainoni, and Rebecca B Perkins

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Reverse lutembacher: a rare late complication of tricuspid valve replacement., Joshua Cowgill, Sebastian Jablonski, Edward Teufel, and James Parker

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Sleep disruption and delirium in the pediatric CICU., Jillian Gregory, Anna Brown, and Sapna Kudchadkar

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Small white spots on the lips., Peggy Rachel Cyr and Leigh Pemberton Johnson

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'Step Up' approach to the application of REBOA technology in a rural, Jack P Vernamonti, John Holcomb, Nathan W Mick, Carolyne Falank, Julianne B Ontengco, Joseph Rappold, and Forest Raymond Sheppard

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Surgical Atrial Fibrillation Ablation Improves Long-Term Survival: A Multicenter Analysis., Alexander Iribarne, Anthony W DiScipio, Jock N McCullough, Reed Quinn, Bruce J Leavitt, Benjamin M Westbrook, Michael P Robich, Gerald L Sardella, John D Klemperer, Robert S Kramer, Paul W Weldner, Elaine M Olmstead, Cathy S Ross, David J Malenka, and Northern New England Cardiovascular Disease Study Group

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T70. IDENTIFYING YOUTH AT CLINICAL HIGH RISK: WHAT'S THE EMOTIONAL IMPACT?...The 2019 Congress of the Schizophrenia International Research Society, April 10-14, 2019, Orlando, Florida, Kristen Woodberry, Kate Powers, Caitlin Bryant, Donna Downing, Mary Verdi, Leda Kennedy, Daniel Shapiro, Ragy Girgis, Gary Brucato, Debbie Huang, Francesca Crump, Cheryl Corcoran, Larry Seidman, Bruce Link, William McFarlane, and Lawrence Yang

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Teaching Benign Skin Lesions as a Strategy to Improve the Triage Amalgamated Dermoscopic Algorithm (TADA)., Elizabeth V Seiverling, Hadjh T Ahrns, Amrit Greene, Melissa Butt, Oriol Yélamos, Stephen W Dusza, and Ashfaq A Marghoob

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The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice., Meghan May, Megan Beauchemin, Calvin Vary, Deborah Barlow, and Karen L Houseknecht

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The Development and Implementation of a Resource Nurse in the Float Pool: A review of the Literature and a Pilot Study Plan, Crystal M. Wiley

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The effect of raloxifene on bone marrow adipose tissue and bone turnover in postmenopausal women with osteoporosis., Kerensa M Beekman, Annegreet G Veldhuis-Vlug, Martin den Heijer, Mario Maas, Ania M Oleksik, Michael W Tanck, Susan M Ott, Rob J van 't Hof, Paul Lips, Peter H Bisschop, and Nathalie Bravenboer

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Therapeutic Irradiation: Consequences for Bone and Bone Marrow Adipose Tissue., Samantha Costa and Michaela R Reagan

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The Relationship Between Uncertainty and Affect., Eric C Anderson, R Nicholas Carleton, Michael Diefenbach, and Paul K J Han

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Transcarotid artery revascularization versus transfemoral carotid artery stenting in the Society for Vascular Surgery Vascular Quality Initiative., Mahmoud B Malas, Hanaa Dakour-Aridi, Grace J Wang, Vikram S Kashyap, Raghu L Motaganahalli, Jens Eldrup-Jorgensen, Jack L Cronenwett, and Marc L Schermerhorn

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Trying to do what is best: a qualitative study of maternal-infant bonding and neonatal abstinence syndrome., Katherin Rockefeller, Lynda C Macken, and Alexa Craig

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U.S. acute care hospital shootings, 2012-2016: A content analysis study., Joseph R Wax, Angelina Cartin, Wendy Craig, and Michael G Pinette

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Vegetarians' and omnivores' affective and physiological responses to images of food., Eric C Anderson, Jolie Wormwood, Lisa Feldman Barrett, and Karen S Quigley

Submissions from 2018

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Parental perceptions of neonatal therapeutic hypothermia; emotional and healing experiences., Alexa K Craig, Christine James, Janelle Bainter, Scott Evans, and Roslyn Gerwin

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A Not-So-New Treatment for Old Bones., Clifford J Rosen

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Use of Masks in Patients with Cystic Fibrosis., Jonathan B Zuckerman and Lisa Saiman

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors., Hyeonwoo Kim, Christiane D Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A Parkman, Scott J Novick, Timothy S Strutzenberg, Bruce D Pascal, Phuong T Le, Daniel J Brooks, Alexander M Roche, Kaitlyn K Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L Bouxsein, Patrick R Griffin, Roland Baron, Clifford J Rosen, Lynda F Bonewald, and Bruce M Spiegelman